dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004549
Uniprot Accession P07259; PYR1_YEAST; A2TBN0; D6VW55; Q06HN1;
Genbank Protein ID NP_012405.2;
Genbank Nucleotide ID NM_001181563.2;
Protein Name Protein URA2
Protein Synonyms/Alias
Gene Name URA2
Gene Synonyms/Alias YJL130C;J0686;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase).
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
3-----MATIAPTAPIPhosphoGRID 2.021126336
575INEKCAKSQAANSVDPhosphoGRID 2.0;curated21126336; 25315811
768VKNSVTKSTCACFEPcurated25315811
793RWDLKKFTRVSTELSPhosphoGRID 2.021126336
796LKKFTRVSTELSSSMPhosphoGRID 2.021126336
797KKFTRVSTELSSSMKcurated22817900; 19547744
1084ENVKILGTSPDMIDScurated25315811
1269CNVRASRSFPFISKVcurated25315811
1295AIMGLPLTPYPVEKLPhosphoGRID 2.0;curated21126336; 24961812
1452NRFRRPASYVSKGYKdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22817900; 19547744
1453RFRRPASYVSKGYKTdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
1490EAISRNITLDVSERDcurated22817900; 19547744
1551YCQLMPRSISGPVITPhosphoGRID 2.021126336
1553QLMPRSISGPVITDVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
1568ASLKAANSVSQDSSYcurated19823750
1570LKAANSVSQDSSYTDcurated19823750
1581SYTDFSFTIAGTAHNcurated19823750
1593AHNAHSVTQSASKVTcurated19823750
1816RVVYNGETLVLSGELPhosphoGRID 2.021126336
1857TSAKRRFSITEEAIAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated1977585; 15665377; 17287358; 17330950; 18407956; 16381945; 2
Sequence
(Fasta)		MATIAPTAPI TPPMESTGDR LVTLELKDGT VLQGYSFGAE KSVAGELVFQ TGMVGYPESV 60
TDPSYEGQIL VITYPLVGNY GVPDMHLRDE LVEELPRYFE SNRIHIAGLV ISHYTDEYSH 120
YLAKSSLGKW LQNEGIPAVY GVDTRSLTKH LRDAGSMLGR LSLEKSGSDR TISRSSSWRS 180
AFDVPEWVDP NVQNLVSKVS INEPKLYVPP ADNKHIELQT GPDGKVLRIL AIDVGMKYNQ 240
IRCFIKRGVE LKVVPWNYDF TKEDYDGLFI SNGPGDPSVL DDLSQRLSNV LEAKKTPVFG 300
ICLGHQLIAR AAGASTLKLK FGNRGHNIPC TSTISGRCYI TSQNHGFAVD VDTLTSGWKP 360
LFVNANDDSN EGIYHSELPY FSVQFHPEST PGPRDTEFLF DVFIQAVKEF KYTQVLKPIA 420
FPGGLLEDNV KAHPRIEAKK VLVLGSGGLS IGQAGEFDYS GSQAIKALKE EGIYTILINP 480
NIATIQTSKG LADKVYFVPV TAEFVRKVIL HERPDAIYVT FGGQTALSVG IAMKDEFEAL 540
GVKVLGTPID TIITTEDREL FSNAIDEINE KCAKSQAANS VDEALAAVKE IGFPVIVRAA 600
YALGGLGSGF ANNEKELVDL CNVAFSSSPQ VLVEKSMKGW KEVEYEVVRD AFDNCITVCN 660
MENFDPLGIH TGDSIVVAPS QTLSDEDYNM LRTTAVNVIR HLGVVGECNI QYALNPVSKD 720
YCIIEVNARL SRSSALASKA TGYPLAYTAA KLGLNIPLNE VKNSVTKSTC ACFEPSLDYC 780
VVKMPRWDLK KFTRVSTELS SSMKSVGEVM SIGRTFEEAI QKAIRSTEYA NLGFNETDLD 840
IDIDYELNNP TDMRVFAIAN AFAKKGYSVD KVWEMTRIDK WFLNKLHDLV QFAEKISSFG 900
TKEELPSLVL RQAKQLGFDD RQIARFLDSN EVAIRRLRKE YGITPFVKQI DTVAAEFPAY 960
TNYLYMTYNA DSHDLSFDDH GVMVLGSGVY RIGSSVEFDW CAVTAVRTLR ANNIKTIMVN 1020
YNPETVSTDY DEADRLYFET INLERVLDIY EIENSSGVVV SMGGQTSNNI AMTLHRENVK 1080
ILGTSPDMID SAENRYKFSR MLDQIGVDQP AWKELTSMDE AESFAEKVGY PVLVRPSYVL 1140
SGAAMNTVYS KNDLESYLNQ AVEVSRDYPV VITKYIENAK EIEMDAVARN GELVMHVVSE 1200
HVENAGVHSG DATLIVPPQD LAPETVDRIV VATAKIGKAL KITGPYNIQF IAKDNEIKVI 1260
ECNVRASRSF PFISKVVGVN LIELATKAIM GLPLTPYPVE KLPDDYVAVK VPQFSFPRLA 1320
GADPVLGVEM ASTGEVATFG HSKYEAYLKS LLATGFKLPK KNILLSIGSY KEKQELLSSV 1380
QKLYNMGYKL FATSGTADFL SEHGIAVQYL EVLNKDDDDQ KSEYSLTQHL ANNEIDLYIN 1440
LPSANRFRRP ASYVSKGYKT RRLAVDYSVP LVTNVKCAKL LIEAISRNIT LDVSERDAQT 1500
SHRTITLPGL INIATYVPNA SHVIKGPAEL KETTRLFLES GFTYCQLMPR SISGPVITDV 1560
ASLKAANSVS QDSSYTDFSF TIAGTAHNAH SVTQSASKVT ALFLPLRELK NKITAVAELL 1620
NQWPTEKQVI AEAKTADLAS VLLLTSLQNR SIHITGVSNK EDLALIMTVK AKDPRVTCDV 1680
NIYSLFIAQD DYPEAVFLPT KEDQEFFWNN LDSIDAFSVG ALPVALANVT GNKVDVGMGI 1740
KDSLPLLLAA VEEGKLTIDD IVLRLHDNPA KIFNIPTQDS VVEIDLDYSF RRNKRWSPFN 1800
KDMNGGIERV VYNGETLVLS GELVSPGAKG KCIVNPSPAS ITASAELQST SAKRRFSITE 1860
EAIADNLDAA EDAIPEQPLE QKLMSSRPPR ELVAPGAIQN LIRSNNPFRG RHILSIKQFK 1920
RSDFHVLFAV AQELRAAVAR EGVLDLMKGH VITTIFFEPS TRTCSSFIAA MERLGGRIVN 1980
VNPLVSSVKK GETLQDTIRT LACYSDAIVM RHSEEMSVHI AAKYSPVPII NGGNGSREHP 2040
TQAFLDLFTI REEIGTVNGI TVTFMGDLKH GRTVHSLCRL LMHYQVRINL VSPPELRLPE 2100
GLREELRKAG LLGVESIELT PHIISKTDVL YCTRVQEERF NSPEEYARLK DTYIVDNKIL 2160
AHAKENMAIM HPLPRVNEIK EEVDYDHRAA YFRQMKYGLF VRMALLAMVM GVDM 2215
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0436--Ligase
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0665--Pyrimidine biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
Interpro

IPR006132--Asp/Orn_carbamoyltranf_P-bd
IPR006130--Asp/Orn_carbamoylTrfase
IPR002082--Asp_carbamoyltransf
IPR006131--Asp_carbamoyltransf_Asp/Orn-bd
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR006275--CarbamoylP_synth_lsu
IPR005480--CarbamoylP_synth_lsu_oligo
IPR006274--CarbamoylP_synth_ssu
IPR002474--CarbamoylP_synth_ssu_N
IPR005479--CbamoylP_synth_lsu-like_ATP-bd
IPR005483--CbamoylP_synth_lsu_CPSase_dom
IPR029062--Class_I_gatase-like
IPR017926--GATASE
IPR032466--Metal_Hydrolase
IPR011607--MGS-like_dom
IPR016185--PreATP-grasp_dom
PROSITE

PS50975--ATP_GRASP
PS00097--CARBAMOYLTRANSFERASE
PS00866--CPSASE_1
PS00867--CPSASE_2
PS51273--GATASE_TYPE_1
Pfam

PF02786--CPSase_L_D2
PF02787--CPSase_L_D3
PF00988--CPSase_sm_chain
PF00117--GATase
PF02142--MGS
PF00185--OTCace
PF02729--OTCace_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0016597--F:amino acid binding
GO:0004070--F:aspartate carbamoyltransferase activity
GO:0005524--F:ATP binding
GO:0004087--F:carbamoyl-phosphate synthase (ammonia) activity
GO:0004088--F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0046872--F:metal ion binding
GO:0006207--P:'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205--P:'de novo' UMP biosynthetic process
GO:0006526--P:arginine biosynthetic process
GO:0006541--P:glutamine metabolic process
GO:0045984--P:negative regulation of pyrimidine nucleobase metabolic process
GO:0000050--P:urea cycle