dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004542
Uniprot Accession P07250; IPMK_YEAST; D6VSF5; E9P8S7;
Genbank Protein ID NP_010458.3;
Genbank Nucleotide ID NM_001180480.3;
Protein Name Inositol polyphosphate multikinase
Protein Synonyms/Alias
Gene Name ARG82
Gene Synonyms/Alias ARGR3;IPK2;YDR173C;YD9395.06C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Has kinase activity and phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. With ARG80, ARG81 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruites ARG80 and MCM21 to stabilize them.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
95LKIDERLSDSTDNLDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 20702584; 21081558;
97IDERLSDSTDNLDSIdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 21177495; 20702584;
98DERLSDSTDNLDSIPdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 19823750; 19795423;
103DSTDNLDSIPVKSEKcurated24961812
177MKIQKNPSVLNQLSLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
314EGPKDKKTTGSLSSMPhosphoGRID 2.021126336
315GPKDKKTTGSLSSMSPhosphoGRID 2.021126336
Sequence
(Fasta)
MDTVNNYRVL EHKAAGHDGT LTDGDGLLIF KPAFPQELEF YKAIQVRDVS RRKSSADGDA 60
PLCSWMPTYL GVLNEGAKIE QSGDAALLKI DERLSDSTDN LDSIPVKSEK SKQYLVLENL 120
LYGFSKPNIL DIKLGKTLYD SKASLEKRER MKRVSETTTS GSLGFRICGM KIQKNPSVLN 180
QLSLEYYEEE ADSDYIFINK LYGRSRTDQN VSDAIELYFN NPHLSDARKH QLKKTFLKRL 240
QLFYNTMLEE EVRMISSSLL FIYEGDPERW ELLNDVDKLM RDDFIDDDDD DDDNDDDDDD 300
DAEGSSEGPK DKKTTGSLSS MSLIDFAHSE ITPGKGYDEN VIEGVETLLD IFMKF 356
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0056--Arginine metabolism
KW-0067--ATP-binding
KW-0106--Calcium
KW-0181--Complete proteome
KW-0418--Kinase
KW-0464--Manganese
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase

Interpro

IPR005522--IPK

PROSITE
Pfam

PF03770--IPK

Gene Ontology

GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000824--F:inositol tetrakisphosphate 3-kinase activity
GO:0000825--F:inositol tetrakisphosphate 6-kinase activity
GO:0000827--F:inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0008440--F:inositol-1,4,5-trisphosphate 3-kinase activity
GO:0000823--F:inositol-1,4,5-trisphosphate 6-kinase activity
GO:0046872--F:metal ion binding
GO:0035004--F:phosphatidylinositol 3-kinase activity
GO:0030674--F:protein binding, bridging
GO:0006525--P:arginine metabolic process
GO:0032958--P:inositol phosphate biosynthetic process
GO:0016236--P:macroautophagy
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0050821--P:protein stabilization
GO:0000821--P:regulation of arginine metabolic process
GO:0006351--P:transcription, DNA-templated