dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004537
Uniprot Accession P07245; C1TC_YEAST; D6VUY6;
Genbank Protein ID NP_011720.3;
Genbank Nucleotide ID NM_001181333.3;
Protein Name C-1-tetrahydrofolate synthase, cytoplasmic
Protein Synonyms/Alias
Gene Name ADE3
Gene Synonyms/Alias YGR204W;G7733;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
17ACAQQFRSNIANEIKcurated25315811
25NIANEIKSIQGHVPGcurated22369663
176GRSDIVGSPVAELLKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 19779198; 22369663;
236GTSSDKKTVVIDVGTcurated26040289
243TVVIDVGTNYVADPScurated26040289
245VIDVGTNYVADPSKKcurated26040289
250TNYVADPSKKSGFKCcurated26040289
318PLPLKLLTPVPSDIDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21126336; 20702584; 19779198;
322KLLTPVPSDIDISRAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 17330950; 19779198; 19060867;
327VPSDIDISRAQQPKLcurated22817900
384LVSGITPTPLGEGKSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
417IANVRQPSLGPTLGVPhosphoPep 2.0;curated19060867; 24961812
434GAAGGGYSQVIPMDEcurated22817900
497GKRKFTPSMQRRLNRSysPTM 2.018407956; 19366988
510NRLGIQKTNPDDLTPcurated25315811
894ATLKGVPTGFTFPIRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MAGQVLDGKA CAQQFRSNIA NEIKSIQGHV PGFAPNLAII QVGNRPDSAT YVRMKRKAAE 60
EAGIVANFIH LDESATEFEV LRYVDQLNED PHTHGIIVQL PLPAHLDEDR ITSRVLAEKD 120
VDGFGPTNIG ELNKKNGHPF FLPCTPKGII ELLHKANVTI EGSRSVVIGR SDIVGSPVAE 180
LLKSLNSTVT ITHSKTRDIA SYLHDADIVV VAIGQPEFVK GEWFKPRDGT SSDKKTVVID 240
VGTNYVADPS KKSGFKCVGD VEFNEAIKYV HLITPVPGGV GPMTVAMLMQ NTLIAAKRQM 300
EESSKPLQIP PLPLKLLTPV PSDIDISRAQ QPKLINQLAQ ELGIYSHELE LYGHYKAKIS 360
PKVIERLQTR QNGKYILVSG ITPTPLGEGK STTTMGLVQA LTAHLGKPAI ANVRQPSLGP 420
TLGVKGGAAG GGYSQVIPMD EFNLHLTGDI HAIGAANNLL AAAIDTRMFH ETTQKNDATF 480
YNRLVPRKNG KRKFTPSMQR RLNRLGIQKT NPDDLTPEEI NKFARLNIDP DTITIKRVVD 540
INDRMLRQIT IGQAPTEKNH TRVTGFDITV ASELMAILAL SKDLRDMKER IGRVVVAADV 600
NRSPVTVEDV GCTGALTALL RDAIKPNLMQ TLEGTPVLVH AGPFANISIG ASSVIADRVA 660
LKLVGTEPEA KTEAGYVVTE AGFDFTMGGE RFFNIKCRSS GLTPNAVVLV ATVRALKSHG 720
GAPDVKPGQP LPSAYTEENI EFVEKGAANM CKQIANIKQF GVPVVVAINK FETDTEGEIA 780
AIRKAALEAG AFEAVTSNHW AEGGKGAIDL AKAVIEASNQ PVDFHFLYDV NSSVEDKLTT 840
IVQKMYGGAA IDILPEAQRK IDMYKEQGFG NLPICIAKTQ YSLSHDATLK GVPTGFTFPI 900
RDVRLSNGAG YLYALAAEIQ TIPGLATYAG YMAVEVDDDG EIDGLF 947
Keyword

KW-0028--Amino-acid biosynthesis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0368--Histidine biosynthesis
KW-0378--Hydrolase
KW-0436--Ligase
KW-0486--Methionine biosynthesis
KW-0511--Multifunctional enzyme
KW-0521--NADP
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0554--One-carbon metabolism
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0658--Purine biosynthesis
KW-1185--Reference proteome
Interpro

IPR000559--Formate_THF_ligase
IPR020628--Formate_THF_ligase_CS
IPR016040--NAD(P)-bd_dom
IPR027417--P-loop_NTPase
IPR000672--THF_DH/CycHdrlase
IPR020630--THF_DH/CycHdrlase_cat_dom
IPR020867--THF_DH/CycHdrlase_CS
IPR020631--THF_DH/CycHdrlase_NAD-bd_dom
PROSITE

PS00721--FTHFS_1
PS00722--FTHFS_2
PS00766--THF_DHG_CYH_1
PS00767--THF_DHG_CYH_2
Pfam

PF01268--FTHFS
PF00763--THF_DHG_CYH
PF02882--THF_DHG_CYH_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004329--F:formate-tetrahydrofolate ligase activity
GO:0004477--F:methenyltetrahydrofolate cyclohydrolase activity
GO:0004488--F:methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0009396--P:folic acid-containing compound biosynthetic process
GO:0006760--P:folic acid-containing compound metabolic process
GO:0000105--P:histidine biosynthetic process
GO:0009086--P:methionine biosynthetic process
GO:0006730--P:one-carbon metabolic process
GO:0009113--P:purine nucleobase biosynthetic process
GO:0006164--P:purine nucleotide biosynthetic process
GO:0035999--P:tetrahydrofolate interconversion