dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004536
Uniprot Accession P07244; PUR2_YEAST; D6VVA0; E9P907;
Genbank Protein ID NP_011280.1;
Genbank Nucleotide ID NM_001181100.1;
Protein Name Bifunctional purine biosynthetic protein ADE5,7
Protein Synonyms/Alias
Gene Name ADE5,7
Gene Synonyms/Alias YGL234W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
23LVTKLAQSPTVGKIYPhosphoGRID 2.0;curated21126336; 22369663
165GKGVIIPSSIDESVQdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 19366988
247YAPAPVATPSLLKTIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812
249PAPVATPSLLKTIDSdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
406RVLSVTSTAQDLRTAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
445RAFQNSESSKVAITYcurated25315811
455VAITYADSGVSVDNGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22369663;
458TYADSGVSVDNGNNLdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 21081558; 19366988;
Sequence
(Fasta)		MLNILVLGNG AREHVLVTKL AQSPTVGKIY VAPGNGGTAT MDPSRVINWD ITPDVANFAR 60
LQSMAVEHKI NLVVPGPELP LVNGITSVFH SVGIPVFGPS VKAAQLEASK AFSKRFMSKH 120
NIPTASYDVF TNPEEAISFL QAHTDKAFVI KADGIAAGKG VIIPSSIDES VQAIKDIMVT 180
KQFGEEAGKQ VVIEQFLEGD EISLLTIVDG YSHFNLPVAQ DHKRIFDGDK GLNTGGMGAY 240
APAPVATPSL LKTIDSQIVK PTIDGMRRDG MPFVGVLFTG MILVKDSKTN QLVPEVLEYN 300
VRFGDPETQA VLSLLDDQTD LAQVFLAAAE HRLDSVNIGI DDTRSAVTVV VAAGGYPESY 360
AKGDKITLDT DKLPPHTQIF QAGTKYDSAT DSLLTNGGRV LSVTSTAQDL RTAVDTVYEA 420
VKCVHFQNSY YRKDIAYRAF QNSESSKVAI TYADSGVSVD NGNNLVQTIK EMVRSTRRPG 480
ADSDIGGFGG LFDLAQAGFR QNEDTLLVGA TDGVGTKLII AQETGIHNTV GIDLVAMNVN 540
DLVVQGAEPL FFLDYFATGA LDIQVASDFV SGVANGCIQS GCALVGGETS EMPGMYPPGH 600
YDTNGTAVGA VLRQDILPKI NEMAAGDVLL GLASSGVHSN GFSLVRKIIQ HVALPWDAPC 660
PWDESKTLGE GILEPTKIYV KQLLPSIRQR LLLGLAHITG GGLVENIPRA IPDHLQARVD 720
MSTWEVPRVF KWFGQAGNVP HDDILRTFNM GVGMVLIVKR ENVKAVCDSL TEEGEIIWEL 780
GSLQERPKDA PGCVIENGTK LY 803
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0436--Ligase
KW-0464--Manganese
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0658--Purine biosynthesis
KW-1185--Reference proteome
Interpro

IPR010918--AIR_synth_C_dom
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR016185--PreATP-grasp_dom
IPR020561--PRibGlycinamid_synth_ATP-grasp
IPR000115--PRibGlycinamide_synth
IPR020560--PRibGlycinamide_synth_C-dom
IPR020559--PRibGlycinamide_synth_CS
IPR020562--PRibGlycinamide_synth_N
IPR016188--PurM-like_N
IPR004733--PurM_cligase
IPR011054--Rudment_hybrid_motif
PROSITE

PS50975--ATP_GRASP
PS00184--GARS
Pfam

PF00586--AIRS
PF02769--AIRS_C
PF01071--GARS_A
PF02843--GARS_C
PF02844--GARS_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004637--F:phosphoribosylamine-glycine ligase activity
GO:0004641--F:phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0006189--P:'de novo' IMP biosynthetic process
GO:0009113--P:purine nucleobase biosynthetic process
GO:0006144--P:purine nucleobase metabolic process