dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004533
Uniprot Accession P07213; TOM70_YEAST; B0KZR5; B0KZS4; B0KZU2; B0KZY7; B0KZZ6; B0L005; B0L023; D6W162;
Genbank Protein ID NP_014278.3;
Genbank Nucleotide ID NM_001182959.3;
Protein Name Mitochondrial import receptor subunit TOM70
Protein Synonyms/Alias 70 kDa mitochondrial outer membrane protein;Translocase of outer membrane 70 kDa subunit;
Gene Name TOM70
Gene Synonyms/Alias MAS70;OMP1;YNL121C;N1905;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
65ETEGAKKSTAPSNPPPhosphoGRID 2.021126336
77NPPIYPVSSNGEPDFPhosphoPep 2.0;curated19060867; 23825934; 25315811
78PPIYPVSSNGEPDFSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
174KVLLRRASANEGLGKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 17563356; 18407956; 16381945; 23193290; 19823750;
228EKFGDIDTATATPTEPhosphoGRID 2.0;curated21126336; 23825934
232DIDTATATPTELSTQdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 21081558; 19060867;
234DTATATPTELSTQPAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 19060867; 19366988;
520TLLTRNPTVENFIEAPhosphoGRID 2.0;curated21126336; 22817900
Sequence
(Fasta)		MKSFITRNKT AILATVAATG TAIGAYYYYN QLQQQQQRGK KNTINKDEKK DTKDSQKETE 60
GAKKSTAPSN PPIYPVSSNG EPDFSNKANF TAEEKDKYAL ALKDKGNQFF RNKKYDDAIK 120
YYNWALELKE DPVFYSNLSA CYVSVGDLKK VVEMSTKALE LKPDYSKVLL RRASANEGLG 180
KFADAMFDLS VLSLNGDFND ASIEPMLERN LNKQAMSKLK EKFGDIDTAT ATPTELSTQP 240
AKERKDKQEN LPSVTSMASF FGIFKPELTF ANYDESNEAD KELMNGLSNL YKRSPESYDK 300
ADESFTKAAR LFEEQLDKNN EDEKLKEKLA ISLEHTGIFK FLKNDPLGAH EDIKKAIELF 360
PRVNSYIYMA LIMADRNDST EYYNYFDKAL KLDSNNSSVY YHRGQMNFIL QNYDQAGKDF 420
DKAKELDPEN IFPYIQLACL AYRENKFDDC ETLFSEAKRK FPEAPEVPNF FAEILTDKND 480
FDKALKQYDL AIELENKLDG IYVGIAPLVG KATLLTRNPT VENFIEATNL LEKASKLDPR 540
SEQAKIGLAQ MKLQQEDIDE AITLFEESAD LARTMEEKLQ AITFAEAAKV QQRIRSDPVL 600
AKKIQETLAK LREQGLM 618
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR005687--Tom70
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00515--TPR_1
PF13414--TPR_11
PF13181--TPR_8
Gene Ontology

GO:0031307--C:integral component of mitochondrial outer membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005742--C:mitochondrial outer membrane translocase complex
GO:0005739--C:mitochondrion
GO:0030943--F:mitochondrion targeting sequence binding
GO:0015450--F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0045039--P:protein import into mitochondrial inner membrane
GO:0030150--P:protein import into mitochondrial matrix
GO:0006626--P:protein targeting to mitochondrion