dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004532
Uniprot Accession P07207; NOTCH_DROME; O97458; P04154; Q9W4T8;
Genbank Protein ID NP_001245510.1; NP_476859.2;
Genbank Nucleotide ID NM_001258581.2; NM_057511.4;
Protein Name Neurogenic locus Notch protein
Protein Synonyms/Alias
Gene Name N
Gene Synonyms/Alias CG3936;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Essential for proper differentiation of ectoderm. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction. Rumi acts in the endoplasmic reticulum to glucosylate the EGF modules in N, this is required for correct folding and cleavage of N.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
2447SPAKSRPSLPTSPTHdbPTM 3.0;Phospho.ELM 9.0;UniProt;curated18327897; 16381945; 23193290; 22817900
2450KSRPSLPTSPTHIQAPhosphoPep 2.0;curated19060867; 22817900
Sequence
(Fasta)		MQSQRSRRRS RAPNTWICFW INKMHAVASL PASLPLLLLT LAFANLPNTV RGTDTALVAA 60
SCTSVGCQNG GTCVTQLNGK TYCACDSHYV GDYCEHRNPC NSMRCQNGGT CQVTFRNGRP 120
GISCKCPLGF DESLCEIAVP NACDHVTCLN GGTCQLKTLE EYTCACANGY TGERCETKNL 180
CASSPCRNGA TCTALAGSSS FTCSCPPGFT GDTCSYDIEE CQSNPCKYGG TCVNTHGSYQ 240
CMCPTGYTGK DCDTKYKPCS PSPCQNGGIC RSNGLSYECK CPKGFEGKNC EQNYDDCLGH 300
LCQNGGTCID GISDYTCRCP PNFTGRFCQD DVDECAQRDH PVCQNGATCT NTHGSYSCIC 360
VNGWAGLDCS NNTDDCKQAA CFYGATCIDG VGSFYCQCTK GKTGLLCHLD DACTSNPCHA 420
DAICDTSPIN GSYACSCATG YKGVDCSEDI DECDQGSPCE HNGICVNTPG SYRCNCSQGF 480
TGPRCETNIN ECESHPCQNE GSCLDDPGTF RCVCMPGFTG TQCEIDIDEC QSNPCLNDGT 540
CHDKINGFKC SCALGFTGAR CQINIDDCQS QPCRNRGICH DSIAGYSCEC PPGYTGTSCE 600
ININDCDSNP CHRGKCIDDV NSFKCLCDPG YTGYICQKQI NECESNPCQF DGHCQDRVGS 660
YYCQCQAGTS GKNCEVNVNE CHSNPCNNGA TCIDGINSYK CQCVPGFTGQ HCEKNVDECI 720
SSPCANNGVC IDQVNGYKCE CPRGFYDAHC LSDVDECASN PCVNEGRCED GINEFICHCP 780
PGYTGKRCEL DIDECSSNPC QHGGTCYDKL NAFSCQCMPG YTGQKCETNI DDCVTNPCGN 840
GGTCIDKVNG YKCVCKVPFT GRDCESKMDP CASNRCKNEA KCTPSSNFLD FSCTCKLGYT 900
GRYCDEDIDE CSLSSPCRNG ASCLNVPGSY RCLCTKGYEG RDCAINTDDC ASFPCQNGGT 960
CLDGIGDYSC LCVDGFDGKH CETDINECLS QPCQNGATCS QYVNSYTCTC PLGFSGINCQ 1020
TNDEDCTESS CLNGGSCIDG INGYNCSCLA GYSGANCQYK LNKCDSNPCL NGATCHEQNN 1080
EYTCHCPSGF TGKQCSEYVD WCGQSPCENG ATCSQMKHQF SCKCSAGWTG KLCDVQTISC 1140
QDAADRKGLS LRQLCNNGTC KDYGNSHVCY CSQGYAGSYC QKEIDECQSQ PCQNGGTCRD 1200
LIGAYECQCR QGFQGQNCEL NIDDCAPNPC QNGGTCHDRV MNFSCSCPPG TMGIICEINK 1260
DDCKPGACHN NGSCIDRVGG FECVCQPGFV GARCEGDINE CLSNPCSNAG TLDCVQLVNN 1320
YHCNCRPGHM GRHCEHKVDF CAQSPCQNGG NCNIRQSGHH CICNNGFYGK NCELSGQDCD 1380
SNPCRVGNCV VADEGFGYRC ECPRGTLGEH CEIDTLDECS PNPCAQGAAC EDLLGDYECL 1440
CPSKWKGKRC DIYDANYPGW NGGSGSGNDR YAADLEQQRA MCDKRGCTEK QGNGICDSDC 1500
NTYACNFDGN DCSLGINPWA NCTANECWNK FKNGKCNEEC NNAACHYDGH DCERKLKSCD 1560
SLFDAYCQKH YGDGFCDYGC NNAECSWDGL DCENKTQSPV LAEGAMSVVM LMNVEAFREI 1620
QAQFLRNMSH MLRTTVRLKK DALGHDIIIN WKDNVRVPEI EDTDFARKNK ILYTQQVHQT 1680
GIQIYLEIDN RKCTECFTHA VEAAEFLAAT AAKHQLRNDF QIHSVRGIKN PGDEDNGEPP 1740
ANVKYVITGI ILVIIALAFF GMVLSTQRKR AHGVTWFPEG FRAPAAVMSR RRRDPHGQEM 1800
RNLNKQVAMQ SQGVGQPGAH WSDDESDMPL PKRQRSDPVS GVGLGNNGGY ASDHTMVSEY 1860
EEADQRVWSQ AHLDVVDVRA IMTPPAHQDG GKHDVDARGP CGLTPLMIAA VRGGGLDTGE 1920
DIENNEDSTA QVISDLLAQG AELNATMDKT GETSLHLAAR FARADAAKRL LDAGADANCQ 1980
DNTGRTPLHA AVAADAMGVF QILLRNRATN LNARMHDGTT PLILAARLAI EGMVEDLITA 2040
DADINAADNS GKTALHWAAA VNNTEAVNIL LMHHANRDAQ DDKDETPLFL AAREGSYEAC 2100
KALLDNFANR EITDHMDRLP RDVASERLHH DIVRLLDEHV PRSPQMLSMT PQAMIGSPPP 2160
GQQQPQLITQ PTVISAGNGG NNGNGNASGK QSNQTAKQKA AKKAKLIEGS PDNGLDATGS 2220
LRRKASSKKT SAASKKAANL NGLNPGQLTG GVSGVPGVPP TNSAAQAAAA AAAAVAAMSH 2280
ELEGSPVGVG MGGNLPSPYD TSSMYSNAMA APLANGNPNT GAKQPPSYED CIKNAQSMQS 2340
LQGNGLDMIK LDNYAYSMGS PFQQELLNGQ GLGMNGNGQR NGVGPGVLPG GLCGMGGLSG 2400
AGNGNSHEQG LSPPYSNQSP PHSVQSSLAL SPHAYLGSPS PAKSRPSLPT SPTHIQAMRH 2460
ATQQKQFGGS NLNSLLGGAN GGGVVGGGGG GGGGVGQGPQ NSPVSLGIIS PTGSDMGIML 2520
APPQSSKNSA IMQTISPQQQ QQQQQQQQQQ HQQQQQQQQQ QQQQQQQQLG GLEFGSAGLD 2580
LNGFCGSPDS FHSGQMNPPS IQSSMSGSSP STNMLSPSSQ HNQQAFYQYL TPSSQHSGGH 2640
TPQHLVQTLD SYPTPSPESP GHWSSSSPRS NSDWSEGVQS PAANNLYISG GHQANKGSEA 2700
IYI 2704
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-0896--Oogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR024600--DUF3454_notch
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR009030--Growth_fac_rcpt_N_dom
IPR008297--Notch
IPR000800--Notch_dom
IPR010660--Notch_NOD_dom
IPR011656--Notch_NODP_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS00010--ASX_HYDROXYL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS50258--LNR
Pfam

PF00023--Ank
PF12796--Ank_2
PF11936--DUF3454
PF00008--EGF
PF07645--EGF_CA
PF12661--hEGF
PF06816--NOD
PF07684--NODP
PF00066--Notch
Gene Ontology

GO:0005912--C:adherens junction
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030139--C:endocytic vesicle
GO:0005788--C:endoplasmic reticulum lumen
GO:0005768--C:endosome
GO:0005796--C:Golgi lumen
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0005770--C:late endosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0035003--C:subapical complex
GO:0005509--F:calcium ion binding
GO:0003682--F:chromatin binding
GO:0004872--F:receptor activity
GO:0004888--F:transmembrane signaling receptor activity
GO:0007015--P:actin filament organization
GO:0009952--P:anterior/posterior pattern specification
GO:0008356--P:asymmetric cell division
GO:0007411--P:axon guidance
GO:0007298--P:border follicle cell migration
GO:0007155--P:cell adhesion
GO:0001708--P:cell fate specification
GO:0022416--P:chaeta development
GO:0008407--P:chaeta morphogenesis
GO:0042676--P:compound eye cone cell fate commitment
GO:0048749--P:compound eye development
GO:0001745--P:compound eye morphogenesis
GO:0046667--P:compound eye retinal cell programmed cell death
GO:0042688--P:crystal cell differentiation
GO:0008340--P:determination of adult lifespan
GO:0046843--P:dorsal appendage formation
GO:0007391--P:dorsal closure
GO:0007451--P:dorsal/ventral lineage restriction, imaginal disc
GO:0007450--P:dorsal/ventral pattern formation, imaginal disc
GO:0007398--P:ectoderm development
GO:0035165--P:embryonic crystal cell differentiation
GO:0035162--P:embryonic hemopoiesis
GO:0061331--P:epithelial cell proliferation involved in Malpighian tubule morphogenesis
GO:0035153--P:epithelial cell type specification, open tracheal system
GO:0060429--P:epithelium development
GO:0042067--P:establishment of ommatidial planar polarity
GO:0035214--P:eye-antennal disc development
GO:0036099--P:female germ-line stem cell population maintenance
GO:0007440--P:foregut morphogenesis
GO:0060288--P:formation of a compartment boundary
GO:0030718--P:germ-line stem cell population maintenance
GO:0060250--P:germ-line stem-cell niche homeostasis
GO:0007293--P:germarium-derived egg chamber formation
GO:0030708--P:germarium-derived female germ-line cyst encapsulation
GO:0010001--P:glial cell differentiation
GO:0007403--P:glial cell fate determination
GO:0008347--P:glial cell migration
GO:0035172--P:hemocyte proliferation
GO:0007157--P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007252--P:I-kappaB phosphorylation
GO:0007446--P:imaginal disc growth
GO:0007447--P:imaginal disc pattern formation
GO:0016348--P:imaginal disc-derived leg joint morphogenesis
GO:0036011--P:imaginal disc-derived leg segmentation
GO:0048803--P:imaginal disc-derived male genitalia morphogenesis
GO:0008587--P:imaginal disc-derived wing margin morphogenesis
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0007474--P:imaginal disc-derived wing vein specification
GO:0036335--P:intestinal stem cell homeostasis
GO:0035171--P:lamellocyte differentiation
GO:0035167--P:larval lymph gland hemopoiesis
GO:0046331--P:lateral inhibition
GO:0007478--P:leg disc morphogenesis
GO:0007616--P:long-term memory
GO:0035170--P:lymph gland crystal cell differentiation
GO:0048542--P:lymph gland development
GO:0061382--P:Malpighian tubule tip cell differentiation
GO:0007498--P:mesoderm development
GO:0016333--P:morphogenesis of follicular epithelium
GO:0008045--P:motor neuron axon guidance
GO:0007521--P:muscle cell fate determination
GO:2000048--P:negative regulation of cell-cell adhesion mediated by cadherin
GO:0045316--P:negative regulation of compound eye photoreceptor development
GO:0035157--P:negative regulation of fusion cell fate specification
GO:0010629--P:negative regulation of gene expression
GO:0046329--P:negative regulation of JNK cascade
GO:0050768--P:negative regulation of neurogenesis
GO:0035155--P:negative regulation of terminal cell fate specification, open tracheal system
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007400--P:neuroblast fate determination
GO:0050877--P:neurological system process
GO:0048666--P:neuron development
GO:0007219--P:Notch signaling pathway
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0030720--P:oocyte localization involved in germarium-derived egg chamber formation
GO:0048477--P:oogenesis
GO:0007424--P:open tracheal system development
GO:0030707--P:ovarian follicle cell development
GO:0007297--P:ovarian follicle cell migration
GO:0030713--P:ovarian follicle cell stalk formation
GO:0007422--P:peripheral nervous system development
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0048052--P:R1/R6 cell differentiation
GO:0007464--P:R3/R4 cell fate commitment
GO:0045466--P:R7 cell differentiation
GO:0045463--P:R8 cell development
GO:0045465--P:R8 cell differentiation
GO:0007460--P:R8 cell fate commitment
GO:0042686--P:regulation of cardioblast cell fate specification
GO:0045595--P:regulation of cell differentiation
GO:0042689--P:regulation of crystal cell differentiation
GO:0051489--P:regulation of filopodium assembly
GO:0040008--P:regulation of growth
GO:0007346--P:regulation of mitotic cell cycle
GO:0050767--P:regulation of neurogenesis
GO:0045468--P:regulation of R8 cell spacing in compound eye
GO:0009608--P:response to symbiont
GO:0046666--P:retinal cell programmed cell death
GO:0016330--P:second mitotic wave involved in compound eye morphogenesis
GO:0007423--P:sensory organ development
GO:0007519--P:skeletal muscle tissue development
GO:0048863--P:stem cell differentiation
GO:0006351--P:transcription, DNA-templated
GO:0007419--P:ventral cord development
GO:0048190--P:wing disc dorsal/ventral pattern formation
GO:0035222--P:wing disc pattern formation
GO:0007473--P:wing disc proximal/distal pattern formation