dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004518
Uniprot Accession P07170; KAD2_YEAST; D6VSK8; Q6Q539;
Genbank Protein ID NP_010512.1;
Genbank Nucleotide ID NM_001180534.1;
Protein Name Adenylate kinase
Protein Synonyms/Alias ATP-AMP transphosphorylase;ATP:AMP phosphotransferase;Adenylate kinase cytosolic and mitochondrial;Adenylate monophosphate kinase;
Gene Name ADK1
Gene Synonyms/Alias AKY;AKY1;AKY2;YDR226W;YD9934.11;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
6--MSSSESIRMVLIGcurated24961812
112QMLKEQGTPLEKAIEcurated25315811
140GRLIHPASGRSYHKIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 19779198; 19060867; 22817900;
193TEPIVDFYKKTGIWAPhosphoPep 2.019060867
Sequence
(Fasta)		MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ LGLEAKKIMD 60
QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA EKLDQMLKEQ GTPLEKAIEL 120
KVDDELLVAR ITGRLIHPAS GRSYHKIFNP PKEDMKDDVT GEALVQRSDD NADALKKRLA 180
AYHAQTEPIV DFYKKTGIWA GVDASQPPAT VWADILNKLG KD 223
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0418--Kinase
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR006259--Adenyl_kin_sub
IPR000850--Adenylat/UMP-CMP_kin
IPR007862--Adenylate_kinase_lid-dom
IPR028587--AK2
IPR027417--P-loop_NTPase
PROSITE

PS00113--ADENYLATE_KINASE
Pfam

PF05191--ADK_lid
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0004017--F:adenylate kinase activity
GO:0005524--F:ATP binding
GO:0006172--P:ADP biosynthetic process
GO:0046033--P:AMP metabolic process
GO:0046034--P:ATP metabolic process
GO:0006270--P:DNA replication initiation
GO:0009117--P:nucleotide metabolic process
GO:0046939--P:nucleotide phosphorylation