dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004515
Uniprot Accession P07149; FAS1_YEAST; D6VX19; Q05747;
Genbank Protein ID NP_012739.1;
Genbank Nucleotide ID NM_001179748.1;
Protein Name Fatty acid synthase subunit beta
Protein Synonyms/Alias
Gene Name FAS1
Gene Synonyms/Alias YKL182W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
Phosphorylation Sites
 dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
417SERKLKFSNRFLPVAcurated24961812
449DLVKNNVSFNAKDIQcurated25315811
733FPIALQWTGGRGGGHPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 26040289; 22369663; 22817900; 25315811
840EQTYKKPTGGIVTVRcurated19823750
848GGIVTVRSEMGEPIHcurated25315811
1113ESPVDVQSQVDSSSVcurated19823750; 25521595
1117DVQSQVDSSSVSEDSdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 25521595
1118VQSQVDSSSVSEDSAcurated22817900
1119QSQVDSSSVSEDSAVcurated22817900; 25521595; 23825934
1121QVDSSSVSEDSAVFKdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
1124SSSVSEDSAVFKATSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26040289; 25521595;
1145WFKALAGSEINWRHAcurated22369663
1177IRKVFKPSQGMVVEIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.017287358; 16381945; 23193290; 19366988
1189VEISNGNTSSKTVVTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.017287358; 16381945; 23193290; 19366988
1190EISNGNTSSKTVVTLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.017287358; 16381945; 23193290; 19366988
1191ISNGNTSSKTVVTLSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.017287358; 16381945; 23193290; 19366988
1482KNANIFSSVKCFGPIcurated22369663
1545PIAVLDSYTPSTNEPcurated26040406
1546IAVLDSYTPSTNEPYcurated26040406
1549LDSYTPSTNEPYARVcurated26040406
Sequence
(Fasta)		MDAYSTRPLT LSHGSLEHVL LVPTASFFIA SQLQEQFNKI LPEPTEGFAA DDEPTTPAEL 60
VGKFLGYVSS LVEPSKVGQF DQVLNLCLTE FENCYLEGND IHALAAKLLQ ENDTTLVKTK 120
ELIKNYITAR IMAKRPFDKK SNSALFRAVG EGNAQLVAIF GGQGNTDDYF EELRDLYQTY 180
HVLVGDLIKF SAETLSELIR TTLDAEKVFT QGLNILEWLE NPSNTPDKDY LLSIPISCPL 240
IGVIQLAHYV VTAKLLGFTP GELRSYLKGA TGHSQGLVTA VAIAETDSWE SFFVSVRKAI 300
TVLFFIGVRC YEAYPNTSLP PSILEDSLEN NEGVPSPMLS ISNLTQEQVQ DYVNKTNSHL 360
PAGKQVEISL VNGAKNLVVS GPPQSLYGLN LTLRKAKAPS GLDQSRIPFS ERKLKFSNRF 420
LPVASPFHSH LLVPASDLIN KDLVKNNVSF NAKDIQIPVY DTFDGSDLRV LSGSISERIV 480
DCIIRLPVKW ETTTQFKATH ILDFGPGGAS GLGVLTHRNK DGTGVRVIVA GTLDINPDDD 540
YGFKQEIFDV TSNGLKKNPN WLEEYHPKLI KNKSGKIFVE TKFSKLIGRP PLLVPGMTPC 600
TVSPDFVAAT TNAGYTIELA GGGYFSAAGM TAAIDSVVSQ IEKGSTFGIN LIYVNPFMLQ 660
WGIPLIKELR SKGYPIQFLT IGAGVPSLEV ASEYIETLGL KYLGLKPGSI DAISQVINIA 720
KAHPNFPIAL QWTGGRGGGH HSFEDAHTPM LQMYSKIRRH PNIMLIFGSG FGSADDTYPY 780
LTGEWSTKFD YPPMPFDGFL FGSRVMIAKE VKTSPDAKKC IAACTGVPDD KWEQTYKKPT 840
GGIVTVRSEM GEPIHKIATR GVMLWKEFDE TIFNLPKNKL VPTLEAKRDY IISRLNADFQ 900
KPWFATVNGQ ARDLATMTYE EVAKRLVELM FIRSTNSWFD VTWRTFTGDF LRRVEERFTK 960
SKTLSLIQSY SLLDKPDEAI EKVFNAYPAA REQFLNAQDI DHFLSMCQNP MQKPVPFVPV 1020
LDRRFEIFFK KDSLWQSEHL EAVVDQDVQR TCILHGPVAA QFTKVIDEPI KSIMDGIHDG 1080
HIKKLLHQYY GDDESKIPAV EYFGGESPVD VQSQVDSSSV SEDSAVFKAT SSTDEESWFK 1140
ALAGSEINWR HASFLCSFIT QDKMFVSNPI RKVFKPSQGM VVEISNGNTS SKTVVTLSEP 1200
VQGELKPTVI LKLLKENIIQ MEMIENRTMD GKPVSLPLLY NFNPDNGFAP ISEVMEDRNQ 1260
RIKEMYWKLW IDEPFNLDFD PRDVIKGKDF EITAKEVYDF THAVGNNCED FVSRPDRTML 1320
APMDFAIVVG WRAIIKAIFP NTVDGDLLKL VHLSNGYKMI PGAKPLQVGD VVSTTAVIES 1380
VVNQPTGKIV DVVGTLSRNG KPVMEVTSSF FYRGNYTDFE NTFQKTVEPV YQMHIKTSKD 1440
IAVLRSKEWF QLDDEDFDLL NKTLTFETET EVTFKNANIF SSVKCFGPIK VELPTKETVE 1500
IGIVDYEAGA SHGNPVVDFL KRNGSTLEQK VNLENPIPIA VLDSYTPSTN EPYARVSGDL 1560
NPIHVSRHFA SYANLPGTIT HGMFSSASVR ALIENWAADS VSSRVRGYTC QFVDMVLPNT 1620
ALKTSIQHVG MINGRKLIKF ETRNEDDVVV LTGEAEIEQP VTTFVFTGQG SQEQGMGMDL 1680
YKTSKAAQDV WNRADNHFKD TYGFSILDIV INNPVNLTIH FGGEKGKRIR ENYSAMIFET 1740
IVDGKLKTEK IFKEINEHST SYTFRSEKGL LSATQFTQPA LTLMEKAAFE DLKSKGLIPA 1800
DATFAGHSLG EYAALASLAD VMSIESLVEV VFYRGMTMQV AVPRDELGRS NYGMIAINPG 1860
RVAASFSQEA LQYVVERVGK RTGWLVEIVN YNVENQQYVA AGDLRALDTV TNVLNFIKLQ 1920
KIDIIELQKS LSLEEVEGHL FEIIDEASKK SAVKPRPLKL ERGFACIPLV GISVPFHSTY 1980
LMNGVKPFKS FLKKNIIKEN VKVARLAGKY IPNLTAKPFQ VTKEYFQDVY DLTGSEPIKE 2040
IIDNWEKYEQ S 2052
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0378--Hydrolase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0456--Lyase
KW-0511--Multifunctional enzyme
KW-0520--NAD
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR001227--Ac_transferase_dom
IPR014043--Acyl_transferase
IPR016035--Acyl_Trfase/lysoPLipase
IPR013565--DUF1729
IPR003965--Fatty_acid_synthase
IPR016452--Fatty_acid_Synthase_bsu_fun
IPR029069--HotDog_dom
IPR002539--MaoC_dom
IPR032088--SAT
PROSITE
Pfam

PF00698--Acyl_transf_1
PF08354--DUF1729
PF01575--MaoC_dehydratas
PF16073--SAT
Gene Ontology

GO:0005829--C:cytosol
GO:0005835--C:fatty acid synthase complex
GO:0005811--C:lipid particle
GO:0019171--F:3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
GO:0047451--F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0004313--F:[acyl-carrier-protein] S-acetyltransferase activity
GO:0004314--F:[acyl-carrier-protein] S-malonyltransferase activity
GO:0004318--F:enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0004319--F:enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0004321--F:fatty-acyl-CoA synthase activity
GO:0016295--F:myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0004320--F:oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296--F:palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0016409--F:palmitoyltransferase activity
GO:0042759--P:long-chain fatty acid biosynthetic process