dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004482
Uniprot Accession P06782; SNF1_YEAST; D6VTA0;
Genbank Protein ID NP_010765.3;
Genbank Nucleotide ID NM_001180785.3;
Protein Name Carbon catabolite-derepressing protein kinase
Protein Synonyms/Alias
Gene Name SNF1
Gene Synonyms/Alias CAT1;CCR1;GLC2;PAS14;YDR477W;D8035.20;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
203FGLSNIMTDGNFLKTdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
210TDGNFLKTSCGSPNYdbPTM 3.0;Phospho.ELM 9.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated7905477; 12748292; 18407956; 16381945; 23193290; 12847291; 1
211DGNFLKTSCGSPNYAdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20489023; 21081558; 19060867;
214FLKTSCGSPNYAAPEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26447709
217TSCGSPNYAAPEVIScurated22817900; 19547744
401KDMKANKSVSDELDTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 22369663;
403MKANKSVSDELDTFLcurated20377248
408SVSDELDTFLSQSPPPhosphoGRID 2.019779198
411DELDTFLSQSPPTFQdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated18407956; 16381945; 23193290; 21081558; 19366988; 22817900;
413LDTFLSQSPPTFQQQdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated12872131; 17330950; 17563356; 18407956; 16381945; 23193290;
416FLSQSPPTFQQQSKSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988
421PPTFQQQSKSHQKSQPhosphoGRID 2.0;curated19779198; 23825934
427QSKSHQKSQVDHETAcurated25315811
443QHARRMASAITQQRTPhosphoGRID 2.0;curated21126336; 22817900; 19547744
487ANMLAQGSPAASKISdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20489023; 21126336; 21081558;
537GAEWAKPSEEDLWTIPhosphoGRID 2.020489023
632ELAVNSQSN------PhosphoGRID 2.0;UniProt;curated19823750; 19795423; 19779198; 25315811
Sequence
(Fasta)		MSSNNNTNTA PANANSSHHH HHHHHHHHHH GHGGSNSTLN NPKSSLADGA HIGNYQIVKT 60
LGEGSFGKVK LAYHTTTGQK VALKIINKKV LAKSDMQGRI EREISYLRLL RHPHIIKLYD 120
VIKSKDEIIM VIEYAGNELF DYIVQRDKMS EQEARRFFQQ IISAVEYCHR HKIVHRDLKP 180
ENLLLDEHLN VKIADFGLSN IMTDGNFLKT SCGSPNYAAP EVISGKLYAG PEVDVWSCGV 240
ILYVMLCRRL PFDDESIPVL FKNISNGVYT LPKFLSPGAA GLIKRMLIVN PLNRISIHEI 300
MQDDWFKVDL PEYLLPPDLK PHPEEENENN DSKKDGSSPD NDEIDDNLVN ILSSTMGYEK 360
DEIYESLESS EDTPAFNEIR DAYMLIKENK SLIKDMKANK SVSDELDTFL SQSPPTFQQQ 420
SKSHQKSQVD HETAKQHARR MASAITQQRT YHQSPFMDQY KEEDSTVSIL PTSLPQIHRA 480
NMLAQGSPAA SKISPLVTKK SKTRWHFGIR SRSYPLDVMG EIYIALKNLG AEWAKPSEED 540
LWTIKLRWKY DIGNKTNTNE KIPDLMKMVI QLFQIETNNY LVDFKFDGWE SSYGDDTTVS 600
NISEDEMSTF SAYPFLHLTT KLIMELAVNS QSN 634
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
IPR013896--Ubiquitin-assoc_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF16579--AdenylateSensor
PF00069--Pkinase
PF08587--UBA_2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000324--C:fungal-type vacuole
GO:0005641--C:nuclear envelope lumen
GO:0031965--C:nuclear membrane
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0005975--P:carbohydrate metabolic process
GO:0007155--P:cell adhesion
GO:0006995--P:cellular response to nitrogen starvation
GO:0071940--P:fungal-type cell wall assembly
GO:0035556--P:intracellular signal transduction
GO:0001403--P:invasive growth in response to glucose limitation
GO:0017148--P:negative regulation of translation
GO:1900436--P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0043547--P:positive regulation of GTPase activity
GO:0016239--P:positive regulation of macroautophagy
GO:0006468--P:protein phosphorylation
GO:0007124--P:pseudohyphal growth
GO:0006109--P:regulation of carbohydrate metabolic process
GO:0001302--P:replicative cell aging
GO:0006986--P:response to unfolded protein
GO:0090606--P:single-species surface biofilm formation