dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004481
Uniprot Accession P06780; RHO1_YEAST; D6W4G6;
Genbank Protein ID NP_015491.1;
Genbank Nucleotide ID NM_001184262.1;
Protein Name GTP-binding protein RHO1
Protein Synonyms/Alias Rho-type GTPase 1;
Gene Name RHO1
Gene Synonyms/Alias YPR165W;P9325.3;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
2------MSQQVGNSIcurated26040289; 22369663; 24961812
8MSQQVGNSIRRKLVIcurated26040406
Sequence
(Fasta)		MSQQVGNSIR RKLVIVGDGA CGKTCLLIVF SKGQFPEVYV PTVFENYVAD VEVDGRRVEL 60
ALWDTAGQED YDRLRPLSYP DSNVVLICFS IDLPDSLENV QEKWIAEVLH FCQGVPIILV 120
GCKVDLRNDP QTIEQLRQEG QQPVTSQEGQ SVADQIGATG YYECSAKTGY GVREVFEAAT 180
RASLMGKSKT NGKAKKNTTE KKKKKCVLL
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0636--Prenylation
KW-1185--Reference proteome
Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR003578--Small_GTPase_Rho
PROSITE

PS51420--RHO
Pfam

PF00071--Ras
Gene Ontology

GO:0000148--C:1,3-beta-D-glucan synthase complex
GO:0005935--C:cellular bud neck
GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0000131--C:incipient cellular bud site
GO:0043332--C:mating projection tip
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0030036--P:actin cytoskeleton organization
GO:0031532--P:actin cytoskeleton reorganization
GO:0007117--P:budding cell bud growth
GO:0045807--P:positive regulation of endocytosis
GO:0090037--P:positive regulation of protein kinase C signaling
GO:0008361--P:regulation of cell size
GO:0090334--P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
GO:0060178--P:regulation of exocyst localization
GO:0060237--P:regulation of fungal-type cell wall organization
GO:0032880--P:regulation of protein localization
GO:0032889--P:regulation of vacuole fusion, non-autophagic
GO:0007264--P:small GTPase mediated signal transduction