dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004476
Uniprot Accession P06774; HAP2_YEAST; D6VV97;
Genbank Protein ID NP_011277.1;
Genbank Nucleotide ID NM_001181103.1;
Protein Name Transcriptional activator HAP2
Protein Synonyms/Alias
Gene Name HAP2
Gene Synonyms/Alias YGL237C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP2 has primarily a structural role in the HAP complexes I and II.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
2------MSADETDAKcurated26040406
6--MSADETDAKFHPLcurated25315811
19PLETDLQSDTAAATScurated25315811
25QSDTAAATSTAAASRcurated19823750
27DTAAATSTAAASRSPPhosphoGRID 2.019779198
31ATSTAAASRSPSLQEPhosphoGRID 2.0;curated19779198; 22817900; 24961812; 25315811
33STAAASRSPSLQEKPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 21126336; 20702584;
35AAASRSPSLQEKPIEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 21126336; 19779198;
52LDMGKAPSPRGEDQRPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated21177495; 19779198; 19060867; 26040406; 22369663; 22817900;
228KAMKSKKSGASDDPDcurated25315811
237ASDDPDDSHEDKKITPhosphoPep 2.0;curated19060867; 25315811
265AAAADKKT-------PhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 26040406; 24961812; 20377248
Sequence
(Fasta)		MSADETDAKF HPLETDLQSD TAAATSTAAA SRSPSLQEKP IEMPLDMGKA PSPRGEDQRV 60
TNEEDLFLFN RLRASQNRVM DSLEPQQQSQ YTSSSVSTME PSADFTSFSA VTTLPPPPHQ 120
QQQQQQQQQQ QQQLVVQAQY TQNQPNLQSD VLGTAIAEQP FYVNAKQYYR ILKRRYARAK 180
LEEKLRISRE RKPYLHESRH KHAMRRPRGE GGRFLTAAEI KAMKSKKSGA SDDPDDSHED 240
KKITTKIIQE QPHATSTAAA ADKKT 266
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR018362--CCAAT-binding_factor_CS
IPR001289--NFYA
PROSITE

PS00686--NFYA_HAP2_1
PS51152--NFYA_HAP2_2
Pfam

PF02045--CBFB_NFYA
Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000436--P:carbon catabolite activation of transcription from RNA polymerase II promoter
GO:0043457--P:regulation of cellular respiration
GO:0006366--P:transcription from RNA polymerase II promoter