dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004452
Uniprot Accession P06701; SIR3_YEAST; D6VZ77; E9P924;
Genbank Protein ID NP_013547.3;
Genbank Nucleotide ID NM_001182330.3;
Protein Name Regulatory protein SIR3
Protein Synonyms/Alias Silent information regulator 3;
Gene Name SIR3
Gene Synonyms/Alias CMT1;MAR2;STE8;YLR442C;L9753.10;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
275STTHGSISPQEESVSPhosphoGRID 2.012640455
315ISKELIVSEEIPINScurated19823750
322SEEIPINSSEQESDYcurated19823750; 24961812; 20377248
323EEIPINSSEQESDYEcurated24961812
327INSSEQESDYEPNNEcurated19823750; 24961812
329SSEQESDYEPNNETScurated19823750; 20377248
336YEPNNETSVLSSKPGcurated19823750
344VLSSKPGSKPEKTSTcurated19823750
454HSMNENPTPEKGNAKPhosphoGRID 2.0;PhosphoPep 2.0;curated20702584; 19779198; 19060867; 26040406; 22817900; 19823750;
502NKLTDEQSSLDVAGLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
692SSKNSKLSIICVGGHcurated22817900
Sequence
(Fasta)		MAKTLKDLDG WQVIITDDQG RVIDDNNRRR SRKRGGENVF LKRISDGLSF GKGESVIFND 60
NVTETYSVYL IHEIRLNTLN NVVEIWVFSY LRWFELKPKL YYEQFRPDLI KEDHPLEFYK 120
DKFFNEVNKS ELYLTAELSE IWLKDFIAVG QILPESQWND SSIDKIEDRD FLVRYACEPT 180
AEKFVPIDIF QIIRRVKEME PKQSDEYLKR VSVPVSGQKT NRQVMHKMGV ERSSKRLAKK 240
PSMKKIKIEP SADDDVNNGN IPSQRGTSTT HGSISPQEES VSPNISSASP SALTSPTDSS 300
KILQKRSISK ELIVSEEIPI NSSEQESDYE PNNETSVLSS KPGSKPEKTS TELVDGRENF 360
VYANNPEVSD DGGLEEETDE VSSESSDEAI IPVNKRRGAH GSELSSKIRK IHIQETQEFS 420
KNYTTETDNE MNGNGKPGIP RGNTKIHSMN ENPTPEKGNA KMIDFATLSK LKKKYQIILD 480
RFAPDNQVTD SSQLNKLTDE QSSLDVAGLE DKFRKACSSS GRETILSNFN ADINLEESIR 540
ESLQKRELLK SQVEDFTRIF LPIYDSLMSS QNKLFYITNA DDSTKFQLVN DVMDELITSS 600
ARKELPIFDY IHIDALELAG MDALYEKIWF AISKENLCGD ISLEALNFYI TNVPKAKKRK 660
TLILIQNPEN LLSEKILQYF EKWISSKNSK LSIICVGGHN VTIREQINIM PSLKAHFTEI 720
KLNKVDKNEL QQMIITRLKS LLKPFHVKVN DKKEMTIYNN IREGQNQKIP DNVIVINHKI 780
NNKITQLIAK NVANVSGSTE KAFKICEAAV EISKKDFVRK GGLQKGKLVV SQEMVPRYFS 840
EAINGFKDET ISKKIIGMSL LMRTFLYTLA QETEGTNRHT LALETVLIKM VKMLRDNPGY 900
KASKEIKKVI CGAWEPAITI EKLKQFSWIS VVNDLVGEKL VVVVLEEPSA SIMVELKLPL 960
EINYAFSMDE EFKNMDCI 979
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR001025--BAH_dom
PROSITE

PS51038--BAH
Pfam

PF01426--BAH
Gene Ontology

GO:0005677--C:chromatin silencing complex
GO:0000781--C:chromosome, telomeric region
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005720--C:nuclear heterochromatin
GO:0005724--C:nuclear telomeric heterochromatin
GO:0005730--C:nucleolus
GO:0003682--F:chromatin binding
GO:0003690--F:double-stranded DNA binding
GO:0042802--F:identical protein binding
GO:0031493--F:nucleosomal histone binding
GO:0031491--F:nucleosome binding
GO:0003697--F:single-stranded DNA binding
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0031507--P:heterochromatin assembly
GO:0001308--P:negative regulation of chromatin silencing involved in replicative cell aging
GO:0070481--P:nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0006351--P:transcription, DNA-templated