dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0004451 |
| Uniprot Accession | P06700; SIR2_YEAST; D6VRV4; |
| Genbank Protein ID | NP_010242.1; |
| Genbank Nucleotide ID | NM_001180101.1; |
| Protein Name | NAD-dependent histone deacetylase SIR2 |
| Protein Synonyms/Alias | Regulatory protein SIR2;Silent information regulator 2; |
| Gene Name | SIR2 |
| Gene Synonyms/Alias | MAR1;YDL042C;D2714; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on histone H3K9Ac and H3K14Ac and histone H4K16Ac in vitro, such activity is unclear in vivo and may not be essential. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MTIPHMKYAV SKTSENKVSN TVSPTQDKDA IRKQPDDIIN NDEPSHKKIK VAQPDSLRET 60 NTTDPLGHTK AALGEVASME LKPTNDMDPL AVSAASVVSM SNDVLKPETP KGPIIISKNP 120 SNGIFYGPSF TKRESLNARM FLKYYGAHKF LDTYLPEDLN SLYIYYLIKL LGFEVKDQAL 180 IGTINSIVHI NSQERVQDLG SAISVTNVED PLAKKQTVRL IKDLQRAINK VLCTRLRLSN 240 FFTIDHFIQK LHTARKILVL TGAGVSTSLG IPDFRSSEGF YSKIKHLGLD DPQDVFNYNI 300 FMHDPSVFYN IANMVLPPEK IYSPLHSFIK MLQMKGKLLR NYTQNIDNLE SYAGISTDKL 360 VQCHGSFATA TCVTCHWNLP GERIFNKIRN LELPLCPYCY KKRREYFPEG YNNKVGVAAS 420 QGSMSERPPY ILNSYGVLKP DITFFGEALP NKFHKSIRED ILECDLLICI GTSLKVAPVS 480 EIVNMVPSHV PQVLINRDPV KHAEFDLSLL GYCDDIAAMV AQKCGWTIPH KKWNDLKNKN 540 FKCQEKDKGV YVVTSDEHPK TL 563 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR029035--DHS-like_NAD/FAD-binding_dom |
| PROSITE | PS50305--SIRTUIN |
| Pfam | |
| Gene Ontology | GO:0005677--C:chromatin silencing complex |