dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004442
Uniprot Accession P06606; TBA4_DROME; Q9VT30;
Genbank Protein ID NP_524009.2;
Genbank Nucleotide ID NM_079285.4;
Protein Name Tubulin alpha-4 chain
Protein Synonyms/Alias
Gene Name alphaTub67C
Gene Synonyms/Alias TubA67C;CG8308;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
45TKEELTASGSSASVGdbPTM 3.0;SysPTM 2.018327897; 16381945; 23193290; 19366988
50TASGSSASVGHDTSAdbPTM 3.0;SysPTM 2.018327897; 16381945; 23193290; 19366988
Sequence
(Fasta)
MREVVSIQIG QCGIQIGNAC WELYLLEHGI NLDGSLKTKE ELTASGSSAS VGHDTSANDA 60
RTFFTETGNG KQVPRSIFVD LEPTVIDDVR NGCMRELYHP EQLISGKEDA ANNYARGRYS 120
IGKEVIDRVT SRLQKIAEQC DSLQGFLIFH SLGGGTGSGF TSLLVERLST DYSKKCKLDF 180
AVYPSPKVST AVVEPYNALL TTHSTMDHSD CVFMVDNEAI YDICNNSLGV DRPAYRNLNR 240
LIAQIVSSTT ASLRFSGSMN VDLNEFQTNL VPFPRIHFPL VAYAPLMSAE RSAHEQHAIT 300
TLTNACFESS NMMVKCDPRA GKFMACCMLY RGDVVPKDVN AAVSAIKSKR HIQFVDWCPT 360
GFKIGINYEK PAFVPDGDLA KTSRACCMLS NTTAISVAFS NLSYKFDLMF KKRAFVHWYV 420
GEGMEEGEFT EARENIAVLE RDFEEVGLDN AEEGGDEDFD EF 463
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0342--GTP-binding
KW-0493--Microtubule
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR002452--Alpha_tubulin
IPR008280--Tub_FtsZ_C
IPR000217--Tubulin
IPR018316--Tubulin/FtsZ_2-layer-sand-dom
IPR023123--Tubulin_C
IPR017975--Tubulin_CS
IPR003008--Tubulin_FtsZ_GTPase

PROSITE

PS00227--TUBULIN

Pfam

PF00091--Tubulin
PF03953--Tubulin_C

Gene Ontology

GO:0055028--C:cortical microtubule
GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0005200--F:structural constituent of cytoskeleton
GO:0007417--P:central nervous system development
GO:0051298--P:centrosome duplication
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0040016--P:embryonic cleavage
GO:0035038--P:female pronucleus assembly
GO:0007017--P:microtubule-based process
GO:0007052--P:mitotic spindle organization
GO:0051028--P:mRNA transport
GO:0022008--P:neurogenesis
GO:0000280--P:nuclear division
GO:0007422--P:peripheral nervous system development
GO:0035046--P:pronuclear migration
GO:0051258--P:protein polymerization
GO:0035044--P:sperm aster formation