dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0004409 |
| Uniprot Accession | P06208; LEU1_YEAST; D6W175; |
| Genbank Protein ID | NP_014295.1; |
| Genbank Nucleotide ID | NM_001182942.1; |
| Protein Name | 2-isopropylmalate synthase |
| Protein Synonyms/Alias | Alpha-IPM synthase;Alpha-isopropylmalate synthase; |
| Gene Name | LEU4 |
| Gene Synonyms/Alias | YNL104C;N2173; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). |
| Phosphorylation Sites |
dbPAF PTMs: 4 |
| Sequence (Fasta) | MVKESIIALA EHAASRASRV IPPVKLAYKN MLKDPSSKYK PFNAPKLSNR KWPDNRITRA 60 PRWLSTDLRD GNQSLPDPMS VEQKKEYFHK LVNIGFKEIE VSFPSASQTD FDFTRYAVEN 120 APDDVSIQCL VQSREHLIKR TVEALTGAKK ATIHTYLATS DMFREIVFNM SREEAISKAV 180 EATKLVRKLT KDDPSQQATR WSYEFSPECF SDTPGEFAVE ICEAVKKAWE PTEENPIIFN 240 LPATVEVASP NVYADQIEYF ATHITEREKV CISTHCHNDR GCGVAATELG MLAGADRVEG 300 CLFGNGERTG NVDLVTVAMN MYTQGVSPNL DFSDLTSVLD VVERCNKIPV SQRAPYGGDL 360 VVCAFSGSHQ DAIKKGFNLQ NKKRAQGETQ WRIPYLPLDP KDIGRDYEAV IRVNSQSGKG 420 GAAWVILRSL GLDLPRNMQI EFSSAVQDHA DSLGRELKSD EISKLFKEAY NYNDEQYQAI 480 SLVNYNVEKF GTERRVFTGQ VKVGDQIVDI EGTGNGPISS LVDALSNLLN VRFAVANYTE 540 HSLGSGSSTQ AASYIHLSYR RNADNEKAYK WGVGVSEDVG DSSVRAIFAT INNIIHSGDV 600 SIPSLAEVEG KNAAASGSA |
| Keyword | KW-0024--Alternative initiation |
| Interpro | IPR013709--2-isopropylmalate_synth_dimer |
| PROSITE | PS00815--AIPM_HOMOCIT_SYNTH_1 |
| Pfam | |
| Gene Ontology | GO:0005737--C:cytoplasm |