dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004398
Uniprot Accession P06103; EIF3B_YEAST; D6W356;
Genbank Protein ID NP_015006.3;
Genbank Nucleotide ID NM_001183781.3;
Protein Name Eukaryotic translation initiation factor 3 subunit B
Protein Synonyms/Alias
Gene Name PRT1
Gene Synonyms/Alias CDC63;YOR361C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
61PVDDIDFSDLEEQYKdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19823750; 19779198; 19795423;
67FSDLEEQYKVTEEFNPhosphoGRID 2.0;UniProt;curated19779198; 22817900
168KDVERYNSDDFDTEFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19366988; 22817900
188PTFVPSSSLKSWLMDcurated20377248
539TDVIKRWSLVKEIPKPhosphoGRID 2.0;curated19823750; 19795423; 22817900
666AWRPRPASILSNAERcurated26040289
669PRPASILSNAERKKVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MKNFLPRTLK NIYELYFNNI SVHSIVSRNT QLKRSKIIQM TTETFEDIKL EDIPVDDIDF 60
SDLEEQYKVT EEFNFDQYIV VNGAPVIPSA KVPVLKKALT SLFSKAGKVV NMEFPIDEAT 120
GKTKGFLFVE CGSMNDAKKI IKSFHGKRLD LKHRLFLYTM KDVERYNSDD FDTEFREPDM 180
PTFVPSSSLK SWLMDDKVRD QFVLQDDVKT SVFWNSMFNE EDSLVESREN WSTNYVRFSP 240
KGTYLFSYHQ QGVTAWGGPN FDRLRRFYHP DVRNSSVSPN EKYLVTFSTE PIIVEEDNEF 300
SPFTKKNEGH QLCIWDIASG LLMATFPVIK SPYLKWPLVR WSYNDKYCAR MVGDSLIVHD 360
ATKNFMPLEA KALKPSGIRD FSFAPEGVKL QPFRNGDEPS VLLAYWTPET NNSACTATIA 420
EVPRGRVLKT VNLVQVSNVT LHWQNQAEFL CFNVERHTKS GKTQFSNLQI CRLTERDIPV 480
EKVELKDSVF EFGWEPHGNR FVTISVHEVA DMNYAIPANT IRFYAPETKE KTDVIKRWSL 540
VKEIPKTFAN TVSWSPAGRF VVVGALVGPN MRRSDLQFYD MDYPGEKNIN DNNDVSASLK 600
DVAHPTYSAA TNITWDPSGR YVTAWSSSLK HKVEHGYKIF NIAGNLVKED IIAGFKNFAW 660
RPRPASILSN AERKKVRKNL REWSAQFEEQ DAMEADTAMR DLILHQRELL KQWTEYREKI 720
GQEMEKSMNF KIFDVQPEDA SDDFTTIEEI VEEVLEETKE KVE 764
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011400--EIF3B
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR013979--TIF_beta_prop-like
PROSITE

PS50102--RRM
Pfam

PF08662--eIF2A
PF00076--RRM_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0010494--C:cytoplasmic stress granule
GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0043614--C:multi-eIF complex
GO:0000166--F:nucleotide binding
GO:0003743--F:translation initiation factor activity
GO:0002183--P:cytoplasmic translational initiation
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation
GO:0006413--P:translational initiation