dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004396
Uniprot Accession P06101; CDC37_YEAST; D6VSE8; Q04132;
Genbank Protein ID NP_010452.1;
Genbank Nucleotide ID NM_001180475.1;
Protein Name Hsp90 co-chaperone Cdc37
Protein Synonyms/Alias Cell division control protein 37;Hsp90 chaperone protein kinase-targeting subunit;
Gene Name CDC37
Gene Synonyms/Alias SMO1;YDR168W;YD9489.03;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Involved in both the HOG and the PKC MAP kinase signaling cascade necessary for adaptation to stress conditions due to high osmolarity or cell wall perturbation.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
14KWDKIELSDDSDVEVdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17220467; 17287358; 17330950; 17563356; 18407956; 16381945;
17KIELSDDSDVEVHPNdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 17563356; 18407956; 16381945; 23193290;
71KRVDRILSNLPESSLcurated22369663; 24961812
172KEKNAHISSEDIHTGcurated22369663; 22817900; 24961812
173EKNAHISSEDIHTGFPhosphoGRID 2.019779198
198GAKPLEATPSEALSScurated22369663
356FLHIQKRSKILQQEEcurated22817900
367QQEEMDESNAEGVETdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated15665377; 18407956; 16381945; 23193290; 21126336; 19823750;
466ENEKDFQSLKDQYEQdbPTM 3.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 24961812
471FQSLKDQYEQDHEDAcurated19823750; 23607784
479EQDHEDATMENLSLNcurated24961812
484DATMENLSLNDRDGGdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 21081558; 19366988;
Sequence
(Fasta)		MAIDYSKWDK IELSDDSDVE VHPNVDKKSF IKWKQQSIHE QRFKRNQDIK NLETQVDMYS 60
HLNKRVDRIL SNLPESSLTD LPAVTKFLNA NFDKMEKSKG ENVDPEIATY NEMVEDLFEQ 120
LAKDLDKEGK DSKSPSLIRD AILKHRAKID SVTVEAKKKL DELYKEKNAH ISSEDIHTGF 180
DSSFMNKQKG GAKPLEATPS EALSSAAESN ILNKLAKSSV PQTFIDFKDD PMKLAKETEE 240
FGKISINEYS KSQKFLLEHL PIISEQQKDA LMMKAFEYQL HGDDKMTLQV IHQSELMAYI 300
KEIYDMKKIP YLNPMELSNV INMFFEKVIF NKDKPMGKES FLRSVQEKFL HIQKRSKILQ 360
QEEMDESNAE GVETIQLKSL DDSTELEVNL PDFNSKDPEE MKKVKVFKTL IPEKMQEAIM 420
TKNLDNINKV FEDIPIEEAE KLLEVFNDID IIGIKAILEN EKDFQSLKDQ YEQDHEDATM 480
ENLSLNDRDG GGDNHEEVKH TADTVD 507
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR004918--Cdc37
IPR013873--Cdc37_C
IPR013874--Cdc37_Hsp90-bd
IPR013855--Cdc37_N_dom
PROSITE
Pfam

PF08564--CDC37_C
PF08565--CDC37_M
PF03234--CDC37_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0051087--F:chaperone binding
GO:0031072--F:heat shock protein binding
GO:0051082--F:unfolded protein binding
GO:0051301--P:cell division
GO:0000161--P:MAPK cascade involved in osmosensory signaling pathway
GO:0006457--P:protein folding
GO:0050821--P:protein stabilization
GO:0051726--P:regulation of cell cycle
GO:0032872--P:regulation of stress-activated MAPK cascade
GO:0030474--P:spindle pole body duplication