dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004394
Uniprot Accession P05990; PYR1_DROME; B5X540; O97163; Q26376; Q7KUX4; Q8SXM0; Q9VXD5;
Genbank Protein ID NP_001285343.1; NP_523377.1;
Genbank Nucleotide ID NM_001298414.1; NM_078653.2;
Protein Name CAD protein
Protein Synonyms/Alias Protein rudimentary;
Gene Name r
Gene Synonyms/Alias CG18572;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Phosphorylation Sites
dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
217CLLQRGASVTLLPWSPhosphoPep 2.0;curated19060867; 22817900
1421GGGARRVSSFMTHGYPhosphoPep 2.0;curated19060867; 22817900
1836SPLASEASQDLLPSDPHOSIDA;curated21081558; 22817900
1883ANFLRPNSPSPRIRLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
1885FLRPNSPSPRIRLDSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
1892SPRIRLDSASNTTLRdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
1894RIRLDSASNTTLREYdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
2010EDSIKVVSSYADVVVcurated22817900
2011DSIKVVSSYADVVVLcurated22817900
2174MMRAKKRSIVLHPLPPhosphoPep 2.0;curated19060867; 22817900
Sequence
(Fasta)
MASTDCYLAL EDGTVLPGYS FGYVPSENES KVGFGGEVVF QTGMVGYTEA LTDRSYSGQI 60
LVLTYPLIGN YGVPAPDEDE HGLPLHFEWM KGVVQATALV VGEVAEEAFH WRKWKTLPDW 120
LKQHKVPGIQ DIDTRALTKK LREQGSMLGK IVYEKPPVEG LPKSSFVDPN VRNLAKECSV 180
KERQVYGNPN GKGPRIAILD CGLKLNQLRC LLQRGASVTL LPWSARLEDE QFDALFLSNG 240
PGNPESCDQI VQQVRKVIEE GQKPVFGICL GHQLLAKAIG CSTYKMKYGN RGHNLPCLHR 300
ATGRCLMTSQ NHGYAVDLEQ LPDGWSELFV NANDGTNEGI VHASKPYFSV QFHPEHHAGP 360
QDTEFLFDVF MESIQQKDLT IPQLIEQRLR PTTPAIDSAP VMPRKVLILG SGGLSIGQAG 420
EFDYSGSQAI KAMRESNIQT VLINPNIATV QTSKGMADKC YFLPLTPHYV EQVIKSERPN 480
GVLLTFGGQT ALNCGVQLER AGVFSKYNVR ILGTPIQSII ETEDRKLFAE RVNEIGEQVA 540
PSEAVYSVAQ ALDAASRLGY PVMARAAFSL GGLGSGFANN EEELQSLAQQ ALAHSSQLIV 600
DKSLKGWKEV EYEVVRDAYN NCITVCNMEN FDPLGIHTGE SIVVAPSQTL SDREYQMLRS 660
TALKVIRHFG VVGECNIQYA LCPHSEQYYI IEVNARLSRS SALASKATGY PLAYVAAKLA 720
LGLPLPDIKN SVTGNTTACF EPSLDYCVVK IPRWDLAKFV RVSKHIGSSM KSVGEVMAIG 780
RNFEEAFQKA LRMVDSDVLG FDPDVVPLNK EQLAEQLSEP TDRRPFVIAA ALQLGMSLRE 840
LHQLTNIDYW FLEKLERIIL LQSLLTRNGS RTDAALLLKA KRFGFSDKQI AKYIKSTELA 900
VRHQRQEFGI RPHVKQIDTV AGEWPASTNY LYHTYNGSEH DVDFPGGHTI VVGSGVYRIG 960
SSVEFDWCAV GCLRELRKLQ RPTIMINYNP ETVSTDYDMC DRLYFEEISF EVVMDIYEME 1020
NSEGIILSMG GQLPNNIAMD LHRQQAKVLG TSPESIDCAE NRFKFSRMLD RKGILQPRWK 1080
ELTNLQSAIE FCEEVGYPCL VRPSYVLSGA AMNVAYSNQD LETYLNAASE VSREHPVVIS 1140
KFLTEAKEID VDAVASDGRI LCMAVSEHVE NAGVHSGDAT LVTPPQDLNA ETLEAIKRIT 1200
CDLASVLDVT GPFNMQLIAK NNELKVIECN VRVSRSFPFV SKTLDHDFVA TATRAIVGLD 1260
VEPLDVLHGV GKVGVKVPQF SFSRLAGADV QLGVEMASTG EVACFGDNRY EAYLKAMMST 1320
GFQIPKNAVL LSIGSFKHKM ELLPSIRDLA KMGYKLYASM GTGDFYAEHG VNVESVQWTF 1380
DKTTPDDING ELRHLAEFLA NKQFDLVINL PMSGGGARRV SSFMTHGYRT RRLAVDYSIP 1440
LVTDVKCTKL LVESMRMNGG KPPMKTHTDC MTSRRIVKLP GFIDVHVHLR EPGATHKEDF 1500
ASGTAAALAG GVTLVCAMPN TNPSIVDRET FTQFQELAKA GARCDYALYV GASDDNWAQV 1560
NELASHACGL KMYLNDTFGT LKLSDMTSWQ RHLSHWPKRS PIVCHAERQS TAAVIMLAHL 1620
LDRSVHICHV ARKEEIQLIR SAKEKGVKVT CEVCPHHLFL STKDVERLGH GMSEVRPLLC 1680
SPEDQEALWE NIDYIDVFAT DHAPHTLAEK RSERPPPGFP GVETILPLLL QAVHEGRLTM 1740
EDIKRKFHRN PKIIFNLPDQ AQTYVEVDLD EEWTITGNEM KSKSGWTPFE GTKVKGRVHR 1800
VVLRGEVAFV DGQVLVQPGF GQNVRPKQSP LASEASQDLL PSDNDANDTF TRLLTSEGPG 1860
GGVHGISTKV HFVDGANFLR PNSPSPRIRL DSASNTTLRE YLQRTTNSNP VAHSLMGKHI 1920
LAVDMFNKDH LNDIFNLAQL LKLRGTKDRP VDELLPGKIM ASVFYEVSTR TQCSFAAAML 1980
RLGGRVISMD NITSSVKKGE SLEDSIKVVS SYADVVVLRH PSPGAVARAA TFSRKPLINA 2040
GDGVGEHPTQ ALLDIFTIRE EFGTVNGLTI TMVGDLKNGR TVHSLARLLT LYNVNLQYVA 2100
PNSLQMPDEV VQFVHQRGVK QLFARDLKNV LPDTDVLYMT RIQRERFDNV EDYEKCCGHL 2160
VLTPEHMMRA KKRSIVLHPL PRLNEISREI DSDPRAAYFR QAEYGMYIRM ALLAMVVGGR 2220
NTAL 2225
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0436--Ligase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0665--Pyrimidine biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc

Interpro

IPR006680--Amidohydro-rel
IPR006132--Asp/Orn_carbamoyltranf_P-bd
IPR006130--Asp/Orn_carbamoylTrfase
IPR002082--Asp_carbamoyltransf
IPR006131--Asp_carbamoyltransf_Asp/Orn-bd
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR006275--CarbamoylP_synth_lsu
IPR005480--CarbamoylP_synth_lsu_oligo
IPR006274--CarbamoylP_synth_ssu
IPR002474--CarbamoylP_synth_ssu_N
IPR005479--CbamoylP_synth_lsu-like_ATP-bd
IPR005483--CbamoylP_synth_lsu_CPSase_dom
IPR029062--Class_I_gatase-like
IPR002195--Dihydroorotase_CS
IPR017926--GATASE
IPR011059--Metal-dep_hydrolase_composite
IPR032466--Metal_Hydrolase
IPR011607--MGS-like_dom
IPR016185--PreATP-grasp_dom

PROSITE

PS50975--ATP_GRASP
PS00097--CARBAMOYLTRANSFERASE
PS00866--CPSASE_1
PS00867--CPSASE_2
PS00482--DIHYDROOROTASE_1
PS00483--DIHYDROOROTASE_2
PS51273--GATASE_TYPE_1

Pfam

PF01979--Amidohydro_1
PF02786--CPSase_L_D2
PF02787--CPSase_L_D3
PF00988--CPSase_sm_chain
PF00117--GATase
PF02142--MGS
PF00185--OTCace
PF02729--OTCace_N

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016597--F:amino acid binding
GO:0004070--F:aspartate carbamoyltransferase activity
GO:0005524--F:ATP binding
GO:0004087--F:carbamoyl-phosphate synthase (ammonia) activity
GO:0004088--F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151--F:dihydroorotase activity
GO:0046872--F:metal ion binding
GO:0006207--P:'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205--P:'de novo' UMP biosynthetic process
GO:0006526--P:arginine biosynthetic process
GO:0006541--P:glutamine metabolic process
GO:0000050--P:urea cycle