dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004359
Uniprot Accession P05694; METE_YEAST; D3DLZ8; P38010; Q02488; Q27JJ8;
Genbank Protein ID NP_011015.3;
Genbank Nucleotide ID NM_001178982.3;
Protein Name 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Protein Synonyms/Alias Cobalamin-independent methionine synthase;Delta-P8 protein;Methionine synthase, vitamin-B12 independent isozyme;
Gene Name MET6
Gene Synonyms/Alias YER091C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
4----MVQSAVLGFPRPhosphoPep 2.019060867
89RYTKYDLSPIDTLFAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19060867; 19366988; 22369663;
135HYVRPTFSKTTQFKLcurated24961812
242YTYFGEQSNLPKITLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 24961812
313WKNDFKKSSAIVNKAcurated25315811
359AEIKGFFSFATQKLDPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 22817900
411AVKARVASIDEKMSTPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 20702584; 19060867; 22817900; 24961812; 25315811
446FPTTTIGSFPQTKDIPhosphoPep 2.0;curated19060867; 26040406; 24961812
558VYAQSITSKPVKGMLPhosphoPep 2.0;curated19060867; 25315811
566KPVKGMLTGPITCLRUniProt;curated19779198; 22817900
629LREGTERSAYYTWAAPhosphoGRID 2.0;UniProt;curated19779198; 22817900
675ALDADVVSIEFSKKDcurated22369663; 22817900; 24961812
679DVVSIEFSKKDDANYcurated22817900
693YIAEFKNYPNHIGLGPhosphoPep 2.019060867
706LGLFDIHSPRIPSKDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 19060867; 19366988;
711IHSPRIPSKDEFIAKPhosphoGRID 2.0;curated19779198; 22817900
752EETRLSLTHMVEAAKcurated25315811
Sequence
(Fasta)		MVQSAVLGFP RIGPNRELKK ATEGYWNGKI TVDELFKVGK DLRTQNWKLQ KEAGVDIIPS 60
NDFSFYDQVL DLSLLFNVIP DRYTKYDLSP IDTLFAMGRG LQRKATETEK AVDVTALEMV 120
KWFDSNYHYV RPTFSKTTQF KLNGQKPVDE FLEAKELGIH TRPVLLGPVS YLFLGKADKD 180
SLDLEPLSLL EQLLPLYTEI LSKLASAGAT EVQIDEPVLV LDLPANAQAA IKKAYTYFGE 240
QSNLPKITLA TYFGTVVPNL DAIKGLPVAA LHVDFVRAPE QFDEVVAAIG NKQTLSVGIV 300
DGRNIWKNDF KKSSAIVNKA IEKLGADRVV VATSSSLLHT PVDLNNETKL DAEIKGFFSF 360
ATQKLDEVVV ITKNVSGQDV AAALEANAKS VESRGKSKFI HDAAVKARVA SIDEKMSTRA 420
APFEQRLPEQ QKVFNLPLFP TTTIGSFPQT KDIRINRNKF NKGTISAEEY EKFINSEIEK 480
VIRFQEEIGL DVLVHGEPER NDMVQYFGEQ INGYAFTVNG WVQSYGSRYV RPPIIVGDLS 540
RPKAMSVKES VYAQSITSKP VKGMLTGPIT CLRWSFPRDD VDQKTQAMQL ALALRDEVND 600
LEAAGIKVIQ VDEPALREGL PLREGTERSA YYTWAAEAFR VATSGVANKT QIHSHFCYSD 660
LDPNHIKALD ADVVSIEFSK KDDANYIAEF KNYPNHIGLG LFDIHSPRIP SKDEFIAKIS 720
TILKSYPAEK FWVNPDCGLK TRGWEETRLS LTHMVEAAKY FREQYKN 768
Keyword

KW-0028--Amino-acid biosynthesis
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0486--Methionine biosynthesis
KW-0489--Methyltransferase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
Interpro

IPR013215--Cbl-indep_Met_Synth_N
IPR006276--Cobalamin-indep_Met_synthase
IPR002629--Met_Synth_C/arc
PROSITE
Pfam

PF08267--Meth_synt_1
PF01717--Meth_synt_2
Gene Ontology

GO:0005829--C:cytosol
GO:0005576--C:extracellular region
GO:0003871--F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008705--F:methionine synthase activity
GO:0008270--F:zinc ion binding
GO:0050667--P:homocysteine metabolic process
GO:0009086--P:methionine biosynthetic process