dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004267
Uniprot Accession P05066; PHR_YEAST; D6W379;
Genbank Protein ID NP_015031.1;
Genbank Nucleotide ID NM_001183806.1;
Protein Name Deoxyribodipyrimidine photo-lyase, mitochondrial
Protein Synonyms/Alias DNA photolyase;Photoreactivating enzyme;
Gene Name PHR1
Gene Synonyms/Alias YOR386W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
197IITANIEYQTDELYRcurated22817900
220DHRLQLKYYHDSCIVPhosphoGRID 2.0;curated21177495; 22817900
221HRLQLKYYHDSCIVAPhosphoGRID 2.0;curated21177495; 22817900
400HCMCNWPYTSMGMPYPhosphoGRID 2.021177495
401CMCNWPYTSMGMPYRPhosphoGRID 2.021177495
Sequence
(Fasta)
MKRTVISSSN AYASKRSRLD IEHDFEQYHS LNKKYYPRPI TRTGANQFNN KSRAKPMEIV 60
EKLQKKQKTS FENVSTVMHW FRNDLRLYDN VGLYKSVALF QQLRQKNAKA KLYAVYVINE 120
DDWRAHMDSG WKLMFIMGAL KNLQQSLAEL HIPLLLWEFH TPKSTLSNSK EFVEFFKEKC 180
MNVSSGTGTI ITANIEYQTD ELYRDIRLLE NEDHRLQLKY YHDSCIVAPG LITTDRGTNY 240
SVFTPWYKKW VLYVNNYKKS TSEICHLHII EPLKYNETFE LKPFQYSLPD EFLQYIPKSK 300
WCLPDVSEEA ALSRLKDFLG TKSSKYNNEK DMLYLGGTSG LSVYITTGRI STRLIVNQAF 360
QSCNGQIMSK ALKDNSSTQN FIKEVAWRDF YRHCMCNWPY TSMGMPYRLD TLDIKWENNP 420
VAFEKWCTGN TGIPIVDAIM RKLLYTGYIN NRSRMITASF LSKNLLIDWR WGERWFMKHL 480
IDGDSSSNVG GWGFCSSTGI DAQPYFRVFN MDIQAKKYDP QMIFVKQWVP ELISSENKRP 540
ENYPKPLVDL KHSRERALKV YKDAM 566
Keyword

KW-0157--Chromophore
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0274--FAD
KW-0285--Flavoprotein
KW-0456--Lyase
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0809--Transit peptide

Interpro

IPR005101--Cryptochr/Photolyase_FAD-bd
IPR002081--Cryptochrome/DNA_photolyase_1
IPR018394--DNA_photolyase_1_CS_C
IPR006050--DNA_photolyase_N
IPR014729--Rossmann-like_a/b/a_fold

PROSITE

PS00394--DNA_PHOTOLYASES_1_1
PS00691--DNA_PHOTOLYASES_1_2
PS51645--PHR_CRY_ALPHA_BETA

Pfam

PF00875--DNA_photolyase
PF03441--FAD_binding_7

Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0003904--F:deoxyribodipyrimidine photo-lyase activity
GO:0003677--F:DNA binding
GO:0003729--F:mRNA binding
GO:0000166--F:nucleotide binding
GO:0000719--P:photoreactive repair
GO:0018298--P:protein-chromophore linkage