dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004261
Uniprot Accession P05030; PMA1_YEAST; D6VUC9;
Genbank Protein ID NP_011507.1;
Genbank Nucleotide ID NM_001180873.1;
Protein Name Plasma membrane ATPase 1
Protein Synonyms/Alias Proton pump 1;
Gene Name PMA1
Gene Synonyms/Alias YGL008C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Phosphorylation Sites
 dbPAF PTMs: 30 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MTDTSSSSSSSSAcurated26040289; 19823750
7-MTDTSSSSSSSSAScurated19823750
8MTDTSSSSSSSSASScurated26040289
9TDTSSSSSSSSASSVcurated26040289; 19823750
10DTSSSSSSSSASSVSPhosphoGRID 2.0;curated19823750; 19795423; 22817900
11TSSSSSSSSASSVSAPhosphoPep 2.0;curated19060867; 19823750
12SSSSSSSSASSVSAHPhosphoPep 2.0;curated19060867; 22369663; 19823750
14SSSSSSASSVSAHQPPhosphoPep 2.0;curated19060867; 26040289; 22369663; 19823750
15SSSSSASSVSAHQPTPhosphoPep 2.0;curated19060867; 26040289; 24961812; 23825934
17SSSASSVSAHQPTQEcurated26040289; 22369663; 19823750
22SVSAHQPTQEKPAKTcurated26040289
52ALIEELQSNHGVDDEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
61HGVDDEDSDNDGPVAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19060867; 19366988
175IVDELKKTLANTAVVPhosphoGRID 2.0;UniProt;curated19779198; 22817900
249GDQTFSSSTVKRGEGcurated25315811
250DQTFSSSTVKRGEGFcurated20377248
261GEGFMVVTATGDNTFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
267VTATGDNTFVGRAAAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
384SDKTGTLTKNKLSLHPhosphoGRID 2.0;curated19823750; 19795423
455FHPFDPVSKKVTAVVcurated24961812
Sequence
(Fasta)		MTDTSSSSSS SSASSVSAHQ PTQEKPAKTY DDAASESSDD DDIDALIEEL QSNHGVDDED 60
SDNDGPVAAG EARPVPEEYL QTDPSYGLTS DEVLKRRKKY GLNQMADEKE SLVVKFVMFF 120
VGPIQFVMEA AAILAAGLSD WVDFGVICGL LMLNAGVGFV QEFQAGSIVD ELKKTLANTA 180
VVIRDGQLVE IPANEVVPGD ILQLEDGTVI PTDGRIVTED CFLQIDQSAI TGESLAVDKH 240
YGDQTFSSST VKRGEGFMVV TATGDNTFVG RAAALVNKAA GGQGHFTEVL NGIGIILLVL 300
VIATLLLVWT ACFYRTNGIV RILRYTLGIT IIGVPVGLPA VVTTTMAVGA AYLAKKQAIV 360
QKLSAIESLA GVEILCSDKT GTLTKNKLSL HEPYTVEGVS PDDLMLTACL AASRKKKGLD 420
AIDKAFLKSL KQYPKAKDAL TKYKVLEFHP FDPVSKKVTA VVESPEGERI VCVKGAPLFV 480
LKTVEEDHPI PEDVHENYEN KVAELASRGF RALGVARKRG EGHWEILGVM PCMDPPRDDT 540
AQTVSEARHL GLRVKMLTGD AVGIAKETCR QLGLGTNIYN AERLGLGGGG DMPGSELADF 600
VENADGFAEV FPQHKYRVVE ILQNRGYLVA MTGDGVNDAP SLKKADTGIA VEGATDAARS 660
AADIVFLAPG LSAIIDALKT SRQIFHRMYS YVVYRIALSL HLEIFLGLWI AILDNSLDID 720
LIVFIAIFAD VATLAIAYDN APYSPKPVKW NLPRLWGMSI ILGIVLAIGS WITLTTMFLP 780
KGGIIQNFGA MNGIMFLQIS LTENWLIFIT RAAGPFWSSI PSWQLAGAVF AVDIIATMFT 840
LFGWWSENWT DIVTVVRVWI WSIGIFCVLG GFYYEMSTSE AFDRLMNGKP MKEKKSTRSV 900
EDFMAAMQRV STQHEKET 919
Keyword

KW-0034--Amyloid
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0375--Hydrogen ion transport
KW-0378--Hydrolase
KW-0406--Ion transport
KW-1017--Isopeptide bond
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0640--Prion
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR004014--ATPase_P-typ_cation-transptr_N
IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR023298--ATPase_P-typ_TM_dom
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR006534--P-type_ATPase_IIIA
IPR001757--P_typ_ATPase
PROSITE

PS00154--ATPASE_E1_E2
Pfam

PF00690--Cation_ATPase_N
PF00122--E1-E2_ATPase
PF00702--Hydrolase
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0008553--F:hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0046872--F:metal ion binding
GO:0006754--P:ATP biosynthetic process
GO:1902600--P:hydrogen ion transmembrane transport
GO:1902906--P:proteasome storage granule assembly
GO:0015992--P:proton transport
GO:0051453--P:regulation of intracellular pH
GO:0006885--P:regulation of pH
GO:0055085--P:transmembrane transport