| Tag |
Content |
| dbPAF ID |
dbPAF-0004245 |
| Uniprot Accession |
P04911; H2A1_YEAST; D6VSK7;
|
| Genbank Protein ID |
NP_010511.3;
|
| Genbank Nucleotide ID |
NM_001180533.3;
|
| Protein Name |
Histone H2A.1 |
| Protein Synonyms/Alias |
|
| Gene Name |
HTA1 |
| Gene Synonyms/Alias |
H2A1;SPT11;YDR225W;YD9934.10; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Functional Description
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSGGKGGKAG SAAKASQSRS AKAGLTFPVG RVHRLLRRGN YAQRIGSGAP VYLTAVLEYL 60
AAEILELAGN AARDNKKTRI IPRHLQLAIR NDDELNKLLG NVTIAQGGVL PNIHQNLLPK 120
KSAKATKASQ EL
133Fasta Sequence
>P04911|HTA1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSGGKGGKAGSAAKASQSRSAKAGLTFPVGRVHRLLRRGNYAQRIGSGAPVYLTAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHQNLLPKKSAKATKASQEL
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0488--Methylation
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
|
| Interpro |
IPR009072--Histone-fold
IPR002119--Histone_H2A
IPR007125--Histone_H2A/H2B/H3
IPR032454--Histone_H2A_C
IPR032458--Histone_H2A_CS
|
| PROSITE |
PS00046--HISTONE_H2A
|
| Pfam |
PF00125--Histone
PF16211--Histone_H2A_C
|
| Gene Ontology |
GO:0000788--C:nuclear nucleosome
GO:0031298--C:replication fork protection complex
GO:0003677--F:DNA binding
GO:0006333--P:chromatin assembly or disassembly
GO:0006281--P:DNA repair
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061587--P:transfer RNA gene-mediated silencing
|
