dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004233
Uniprot Accession P04840; VDAC1_YEAST; D6W1C3;
Genbank Protein ID NP_014343.1;
Genbank Nucleotide ID NM_001182894.1;
Protein Name Mitochondrial outer membrane protein porin 1
Protein Synonyms/Alias Voltage-dependent anion-selective channel protein 1;VDAC-1;
Gene Name POR1
Gene Synonyms/Alias OMP2;VDAC1;YNL055C;N2441;YNL2441C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Is the major permeability fator of the mitochondrial outer membrane.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
2------MSPPVYSDIdbPTM 3.0;PhosphoGRID 2.0;curated18407956; 16381945; 23193290; 21126336; 20702584; 22369663;
6--MSPPVYSDISRNIcurated26040289
7-MSPPVYSDISRNINcurated26040289
56VKDGPLSTNVEAKLNcurated25315811
91KLEFANLTPGLKNELPhosphoGRID 2.0;curated21126336; 22817900; 24961812; 20377248
100GLKNELITSLTPGVAPhosphoGRID 2.021126336
101LKNELITSLTPGVAKcurated24961812
103NELITSLTPGVAKSAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 22817900;
109LTPGVAKSAVLNTTFdbPTM 3.0;PhosphoGRID 2.0;UniProt;curated17761666; 16381945; 23193290; 19779198; 22817900
117AVLNTTFTQPFFTARdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MSPPVYSDIS RNINDLLNKD FYHATPAAFD VQTTTANGIK FSLKAKQPVK DGPLSTNVEA 60
KLNDKQTGLG LTQGWSNTNN LQTKLEFANL TPGLKNELIT SLTPGVAKSA VLNTTFTQPF 120
FTARGAFDLC LKSPTFVGDL TMAHEGIVGG AEFGYDISAG SISRYAMALS YFAKDYSLGA 180
TLNNEQITTV DFFQNVNAFL QVGAKATMNC KLPNSNVNIE FATRYLPDAS SQVKAKVSDS 240
GIVTLAYKQL LRPGVTLGVG SSFDALKLSE PVHKLGWSLS FDA 284
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0406--Ion transport
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0597--Phosphoprotein
KW-0626--Porin
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1134--Transmembrane beta strand
KW-0813--Transport
Interpro

IPR023614--Porin_dom
IPR001925--Porin_Euk
IPR027246--Porin_Euk/Tom40
PROSITE

PS00558--EUKARYOTIC_PORIN
Pfam

PF01459--Porin_3
Gene Ontology

GO:0031307--C:integral component of mitochondrial outer membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0046930--C:pore complex
GO:0015288--F:porin activity
GO:0008308--F:voltage-gated anion channel activity
GO:0006915--P:apoptotic process
GO:0045454--P:cell redox homeostasis
GO:0051027--P:DNA transport
GO:0006811--P:ion transport
GO:0007005--P:mitochondrion organization
GO:1903959--P:regulation of anion transmembrane transport