dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004231
Uniprot Accession P04821; CDC25_YEAST; D6VYV4;
Genbank Protein ID NP_013413.1;
Genbank Nucleotide ID NM_001182198.1;
Protein Name Cell division control protein 25
Protein Synonyms/Alias
Gene Name CDC25
Gene Synonyms/Alias CTN1;YLR310C;L2142.6;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.
Phosphorylation Sites
 dbPAF PTMs: 57 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSDTNTSIPcurated26040289
7-MSDTNTSIPNTSSAcurated22369663
77NYPIKKDSSSQLLSVPhosphoGRID 2.010529198
135DSHLRKHSHPMKKYSPhosphoGRID 2.010529198
142SHPMKKYSSSKSSRRPhosphoGRID 2.010529198
146KKYSSSKSSRRSSLNcurated19823750
147KYSSSKSSRRSSLNScurated24961812
150SSKSSRRSSLNSLGNPhosphoPep 2.0;curated19060867; 25704821; 24961812; 25315811
151SKSSRRSSLNSLGNSdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 17330950; 20489023;
154SRRSSLNSLGNSAYLdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 17330950; 20489023;
174PSKSRRGSSTLSASLPhosphoGRID 2.010529198
222PQSSNFNSNASLSQDdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
238TKSADGSSEMNTNAIcurated25315811
365NANIEDSSTRSKQSEcurated25315811
379ESEQNRSSLLMEKQDcurated24961812; 25315811
396ETDGNNNSINDDDNNcurated25521595; 25315811
418FNEAGPSSLNSLSAPcurated25315811
421AGPSSLNSLSAPDLTPHOSIDA;curated21081558; 22369663; 22817900; 19795423; 25521595; 25315811
423PSSLNSLSAPDLTQNdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21081558; 19366988; 22369663;
580DGKIEVDSVHDLVSVPhosphoGRID 2.0;UniProt;curated19779198; 26040289; 22817900; 25315811; 20377248
Sequence
(Fasta)		MSDTNTSIPN TSSAREAGNA SQTPSISSSS NTSTTTNTES SSASLSSSPS TSELTSIRPI 60
GIVVAAYDFN YPIKKDSSSQ LLSVQQGETI YILNKNSSGW WDGLVIDDSN GKVNRGWFPQ 120
NFGRPLRDSH LRKHSHPMKK YSSSKSSRRS SLNSLGNSAY LHVPRNPSKS RRGSSTLSAS 180
LSNAHNAETS SGHNNTVSMN NSPFSAPNDA SHITPQSSNF NSNASLSQDM TKSADGSSEM 240
NTNAIMNNNE TNLQTSGEKA GPPLVAEETI KILPLEEIEM IINGIRSNIA STWSPIPLIT 300
KTSDYKLVYY NKDLDIYCSE LPLISNSIME SDDICDSEPK FPPNDHLVNL YTRDLRKNAN 360
IEDSSTRSKQ SESEQNRSSL LMEKQDSKET DGNNNSINDD DNNNENNKNE FNEAGPSSLN 420
SLSAPDLTQN IQSRVVAPSR SSILAKSDIF YHYSRDIKLW TELQDLTVYY TKTAHKMFLK 480
ENRLNFTKYF DLISDSIVFT QLGCRLMQHE IKAKSCSKEI KKIFKGLISS LSRISINSHL 540
YFDSAFHRKK MDTMNDKDND NQENNCSRTE GDDGKIEVDS VHDLVSVPLS GKRNVSTSTT 600
DTLTPMRSSF STVNENDMEN FSVLGPRNSV NSVVTPRTSI QNSTLEDFSP SNKNFKSAKS 660
IYEMVDVEFS KFLRHVQLLY FVLQSSVFSD DNTLPQLLPR FFKGSFSGGS WTNPFSTFIT 720
DEFGNATKNK AVTSNEVTAS SSKNSSISRI PPKMADAIAS ASGYSANSET NSQIDLKASS 780
AASGSVFTPF NRPSHNRTFS RARVSKRKKK YPLTVDTLNT MKKKSSQIFE KLNNATGEHL 840
KIISKPKSRI RNLEINSSTY EQINQNVLLL EILENLDLSI FINLKNLIKT PSILLDLESE 900
EFLVHAMSSV SSVLTEFFDI KQAFHDIVIR LIMTTQQTTL DDPYLFSSMR SNFPVGHHEP 960
FKNISNTPLV KGPFHKKNEQ LALSLFHVLV SQDVEFNNLE FLNNSDDFKD ACEKYVEISN 1020
LACIIVDQLI EERENLLNYA ARMMKNNLTA ELLKGEQEKW FDIYSEDYSD DDSENDEAII 1080
DDELGSEDYI ERKAANIEKN LPWFLTSDYE TSLVYDSRGK IRGGTKEALI EHLTSHELVD 1140
AAFNVTMLIT FRSILTTREF FYALIYRYNL YPPEGLSYDD YNIWIEKKSN PIKCRVVNIM 1200
RTFLTQYWTR NYYEPGIPLI LNFAKMVVSE KIPGAEDLLQ KINEKLINEN EKEPVDPKQQ 1260
DSVSAVVQTT KRDNKSPIHM SSSSLPSSAS SAFFRLKKLK LLDIDPYTYA TQLTVLEHDL 1320
YLRITMFECL DRAWGTKYCN MGGSPNITKF IANANTLTNF VSHTIVKQAD VKTRSKLTQY 1380
FVTVAQHCKE LNNFSSMTAI VSALYSSPIY RLKKTWDLVS TESKDLLKNL NNLMDSKRNF 1440
VKYRELLRSV TDVACVPFFG VYLSDLTFTF VGNPDFLHNS TNIINFSKRT KIANIVEEII 1500
SFKRFHYKLK RLDDIQTVIE ASLENVPHIE KQYQLSLQVE PRSGNTKGST HASSASGTKT 1560
AKFLSEFTDD KNGNFLKLGK KKPPSRLFR
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0472--Membrane
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000651--Ras-like_Gua-exchang_fac_N
IPR019804--Ras_G-nucl-exch_fac_CS
IPR023578--Ras_GEF_dom
IPR001895--RASGEF_cat_dom
IPR001452--SH3_domain
PROSITE

PS00720--RASGEF
PS50009--RASGEF_CAT
PS50212--RASGEF_NTER
PS50002--SH3
Pfam

PF00617--RasGEF
PF00618--RasGEF_N
PF00018--SH3_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005088--F:Ras guanyl-nucleotide exchange factor activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction
GO:0051726--P:regulation of cell cycle
GO:0001302--P:replicative cell aging
GO:0007089--P:traversing start control point of mitotic cell cycle