dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004230
Uniprot Accession P04819; DNLI1_YEAST; D6VRI7; Q12736;
Genbank Protein ID NP_010117.1;
Genbank Nucleotide ID NM_001180224.1;
Protein Name DNA ligase 1
Protein Synonyms/Alias DNA ligase I;Polydeoxyribonucleotide synthase [ATP] 1;
Gene Name CDC9
Gene Synonyms/Alias YDL164C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
18SSARPLKSRLPLLMScurated22817900; 19823750
25SRLPLLMSSSLPSSAcurated19823750
26RLPLLMSSSLPSSAGcurated19823750
30LMSSSLPSSAGKKPKcurated19823750
31MSSSLPSSAGKKPKQcurated19823750
53TSMKNKPTEGTPSPKcurated22817900; 19823750
56KNKPTEGTPSPKKSSPhosphoGRID 2.0;curated19823750; 19795423; 25315811
58KPTEGTPSPKKSSKHdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17563356; 18407956; 16381945; 23193290; 19823750;
75EDRMDNVSGEEEYATdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 18407956; 16381945; 23193290; 21177495; 21126336;
119PSSGVADSPQQSQRLPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 26040289; 22817900; 25315811
123VADSPQQSQRLVGEVPhosphoGRID 2.0;UniProt;curated19779198; 22817900
337HDENREDSPDKDVPMcurated26040406; 24961812; 25315811
Sequence
(Fasta)		MRRLLTGCLL SSARPLKSRL PLLMSSSLPS SAGKKPKQAT LARFFTSMKN KPTEGTPSPK 60
KSSKHMLEDR MDNVSGEEEY ATKKLKQTAV THTVAAPSSM GSNFSSIPSS APSSGVADSP 120
QQSQRLVGEV EDALSSNNND HYSSNIPYSE VCEVFNKIEA ISSRLEIIRI CSDFFIKIMK 180
QSSKNLIPTT YLFINRLGPD YEAGLELGLG ENLLMKTISE TCGKSMSQIK LKYKDIGDLG 240
EIAMGARNVQ PTMFKPKPLT VGEVFKNLRA IAKTQGKDSQ LKKMKLIKRM LTACKGIEAK 300
FLIRSLESKL RIGLAEKTVL ISLSKALLLH DENREDSPDK DVPMDVLESA QQKIRDAFCQ 360
VPNYEIVINS CLEHGIMNLD KYCTLRPGIP LKPMLAKPTK AINEVLDRFQ GETFTSEYKY 420
DGERAQVHLL NDGTMRIYSR NGENMTERYP EINITDFIQD LDTTKNLILD CEAVAWDKDQ 480
GKILPFQVLS TRKRKDVELN DVKVKVCLFA FDILCYNDER LINKSLKERR EYLTKVTKVV 540
PGEFQYATQI TTNNLDELQK FLDESVNHSC EGLMVKMLEG PESHYEPSKR SRNWLKLKKD 600
YLEGVGDSLD LCVLGAYYGR GKRTGTYGGF LLGCYNQDTG EFETCCKIGT GFSDEMLQLL 660
HDRLTPTIID GPKATFVFDS SAEPDVWFEP TTLFEVLTAD LSLSPIYKAG SATFDKGVSL 720
RFPRFLRIRE DKGVEDATSS DQIVELYENQ SHMQN 756
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0024--Alternative initiation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0235--DNA replication
KW-0436--Ligase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR000977--DNA_ligase_ATP-dep
IPR012309--DNA_ligase_ATP-dep_C
IPR012310--DNA_ligase_ATP-dep_cent
IPR016059--DNA_ligase_ATP-dep_CS
IPR012308--DNA_ligase_ATP-dep_N
IPR012340--NA-bd_OB-fold
PROSITE

PS00697--DNA_LIGASE_A1
PS00333--DNA_LIGASE_A2
PS50160--DNA_LIGASE_A3
Pfam

PF04679--DNA_ligase_A_C
PF01068--DNA_ligase_A_M
PF04675--DNA_ligase_A_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003910--F:DNA ligase (ATP) activity
GO:0046872--F:metal ion binding
GO:0006284--P:base-excision repair
GO:0051301--P:cell division
GO:0071897--P:DNA biosynthetic process
GO:0006266--P:DNA ligation
GO:0006310--P:DNA recombination
GO:0006273--P:lagging strand elongation
GO:0035753--P:maintenance of DNA trinucleotide repeats
GO:0000278--P:mitotic cell cycle
GO:0006289--P:nucleotide-excision repair
GO:1903461--P:Okazaki fragment processing involved in mitotic DNA replication
GO:1903469--P:removal of RNA primer involved in mitotic DNA replication