dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004227
Uniprot Accession P04807; HXKB_YEAST; D6VV82; Q05838;
Genbank Protein ID NP_011261.1;
Genbank Nucleotide ID NM_001181119.1;
Protein Name Hexokinase-2
Protein Synonyms/Alias Hexokinase PII;Hexokinase-B;
Gene Name HXK2
Gene Synonyms/Alias HEX1;HKB;YGL253W;NRB486;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
15KPQARKGSMADVPKEdbPTM 3.0;PhosphoPep 2.0;UniProt;curated8286332; 9718324; 11875433; 16381945; 23193290; 19060867; 19
35ENFEKIFTVPTETLQcurated22817900
38EKIFTVPTETLQAVTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 24961812
50AVTKHFISELEKGLSPhosphoGRID 2.0;curated19779198; 22817900; 25315811; 19547744
110RTFDTTQSKYRLPDAcurated25315811
158IPLGFTFSFPASQNKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated9047292; 18407956; 16381945; 23193290; 19366988
245GAYYDVCSDIEKLQGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 26040406;
272AINCEYGSFDNEHVVdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
285VVLPRTKYDITIDEEcurated20377248
293DITIDEESPRPGQQTcurated22369663; 19823750; 24961812; 25315811; 20377248
385RKLIRRLSELIGARAcurated25315811
396GARAARLSVCGIAAIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
419GHIAADGSVYNRYPGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 22369663;
421IAADGSVYNRYPGFKcurated20377248
Sequence
(Fasta)		MVHLGPKKPQ ARKGSMADVP KELMQQIENF EKIFTVPTET LQAVTKHFIS ELEKGLSKKG 60
GNIPMIPGWV MDFPTGKESG DFLAIDLGGT NLRVVLVKLG GDRTFDTTQS KYRLPDAMRT 120
TQNPDELWEF IADSLKAFID EQFPQGISEP IPLGFTFSFP ASQNKINEGI LQRWTKGFDI 180
PNIENHDVVP MLQKQITKRN IPIEVVALIN DTTGTLVASY YTDPETKMGV IFGTGVNGAY 240
YDVCSDIEKL QGKLSDDIPP SAPMAINCEY GSFDNEHVVL PRTKYDITID EESPRPGQQT 300
FEKMSSGYYL GEILRLALMD MYKQGFIFKN QDLSKFDKPF VMDTSYPARI EEDPFENLED 360
TDDLFQNEFG INTTVQERKL IRRLSELIGA RAARLSVCGI AAICQKRGYK TGHIAADGSV 420
YNRYPGFKEK AANALKDIYG WTQTSLDDYP IKIVPAEDGS GAGAAVIAAL AQKRIAEGKS 480
VGIIGA 487
Keyword

KW-0002--3D-structure
KW-0021--Allosteric enzyme
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0324--Glycolysis
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR001312--Hexokinase
IPR019807--Hexokinase_BS
IPR022673--Hexokinase_C
IPR022672--Hexokinase_N
PROSITE

PS00378--HEXOKINASE_1
PS51748--HEXOKINASE_2
Pfam

PF00349--Hexokinase_1
PF03727--Hexokinase_2
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0008865--F:fructokinase activity
GO:0004340--F:glucokinase activity
GO:0005536--F:glucose binding
GO:0004396--F:hexokinase activity
GO:0019158--F:mannokinase activity
GO:0001678--P:cellular glucose homeostasis
GO:0032445--P:fructose import
GO:0006000--P:fructose metabolic process
GO:0051156--P:glucose 6-phosphate metabolic process
GO:0046323--P:glucose import
GO:0006006--P:glucose metabolic process
GO:0006096--P:glycolytic process
GO:0006013--P:mannose metabolic process
GO:0046015--P:regulation of transcription by glucose
GO:0001302--P:replicative cell aging