dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004226
Uniprot Accession P04806; HXKA_YEAST; D6VTT6;
Genbank Protein ID NP_116711.3;
Genbank Nucleotide ID NM_001180018.3;
Protein Name Hexokinase-1
Protein Synonyms/Alias Hexokinase PI;Hexokinase-A;
Gene Name HXK1
Gene Synonyms/Alias HKA;YFR053C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
15KPQARKGSMADVPKEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated11875433; 17287358; 17330950; 17563356; 18407956; 16381945;
90LAIDLGGTNLRVVLVcurated22817900
104VKLSGNHTFDTTQSKcurated22369663; 22817900; 19547744
110HTFDTTQSKYKLPHDcurated25315811
112FDTTQSKYKLPHDMRcurated26040406
120KLPHDMRTTKHQEELcurated26040406
121LPHDMRTTKHQEELWcurated26040406
156DTLPLGFTFSYPASQcurated22817900
158LPLGFTFSYPASQNKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 22817900;
159PLGFTFSYPASQNKIcurated22817900
175EGILQRWTKGFDIPNcurated24961812
197PLLQNEISKRELPIEcurated22369663
245GAFYDVVSDIEKLEGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 22369663
262ADDIPSNSPMAINCEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
272AINCEYGSFDNEHLVdbPTM 3.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 22369663
293DVAVDEQSPRPGQQAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
361PFENLEDTDDIFQKDcurated22817900
419GHIAADGSVYNKYPGPhosphoGRID 2.0;curated19779198; 22369663; 22817900; 24961812
Sequence
(Fasta)		MVHLGPKKPQ ARKGSMADVP KELMDEIHQL EDMFTVDSET LRKVVKHFID ELNKGLTKKG 60
GNIPMIPGWV MEFPTGKESG NYLAIDLGGT NLRVVLVKLS GNHTFDTTQS KYKLPHDMRT 120
TKHQEELWSF IADSLKDFMV EQELLNTKDT LPLGFTFSYP ASQNKINEGI LQRWTKGFDI 180
PNVEGHDVVP LLQNEISKRE LPIEIVALIN DTVGTLIASY YTDPETKMGV IFGTGVNGAF 240
YDVVSDIEKL EGKLADDIPS NSPMAINCEY GSFDNEHLVL PRTKYDVAVD EQSPRPGQQA 300
FEKMTSGYYL GELLRLVLLE LNEKGLMLKD QDLSKLKQPY IMDTSYPARI EDDPFENLED 360
TDDIFQKDFG VKTTLPERKL IRRLCELIGT RAARLAVCGI AAICQKRGYK TGHIAADGSV 420
YNKYPGFKEA AAKGLRDIYG WTGDASKDPI TIVPAEDGSG AGAAVIAALS EKRIAEGKSL 480
GIIGA 486
Keyword

KW-0002--3D-structure
KW-0021--Allosteric enzyme
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0324--Glycolysis
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR001312--Hexokinase
IPR019807--Hexokinase_BS
IPR022673--Hexokinase_C
IPR022672--Hexokinase_N
PROSITE

PS00378--HEXOKINASE_1
PS51748--HEXOKINASE_2
Pfam

PF00349--Hexokinase_1
PF03727--Hexokinase_2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0008865--F:fructokinase activity
GO:0004340--F:glucokinase activity
GO:0005536--F:glucose binding
GO:0004396--F:hexokinase activity
GO:0019158--F:mannokinase activity
GO:0001678--P:cellular glucose homeostasis
GO:0032445--P:fructose import
GO:0006000--P:fructose metabolic process
GO:0051156--P:glucose 6-phosphate metabolic process
GO:0046323--P:glucose import
GO:0006006--P:glucose metabolic process
GO:0006096--P:glycolytic process
GO:0006013--P:mannose metabolic process