dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004224
Uniprot Accession P04801; SYTC_YEAST; D6VVK6;
Genbank Protein ID NP_116578.3;
Genbank Nucleotide ID NM_001179428.3;
Protein Name Threonine--tRNA ligase, cytoplasmic
Protein Synonyms/Alias Threonyl-tRNA synthetase;ThrRS;
Gene Name THS1
Gene Synonyms/Alias YIL078W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSASEAGVTPhosphoGRID 2.0;PHOSIDA;curated19823750; 19795423; 21081558; 26040406; 26040289; 22369663
4----MSASEAGVTEQdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated15665377; 16381945; 23193290; 19366988; 26040406; 22369663;
20KKLSVKDSSNDAVKPcurated25315811
21KLSVKDSSNDAVKPNcurated25315811
41KSKQQSLYLDPEPTFcurated22369663; 25315811
47LYLDPEPTFIEERIEcurated22369663; 22817900; 19547744
63FDRLQKEYNDKVASMPhosphoGRID 2.0;curated19823750; 19795423; 22817900
69EYNDKVASMPRVPLKPhosphoGRID 2.0;curated21126336; 19823750; 19795423; 22817900
193RDSMKDISESPERTVPhosphoGRID 2.0;curated19823750; 19795423; 26040406; 24961812; 25315811; 20377248
195SMKDISESPERTVSQdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 20702584; 19823750;
199ISESPERTVSQADFPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 19366988; 25521595
201ESPERTVSQADFPGLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22817900; 24961812;
289FKLLKNSSCYFLGDAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22817900;
291LLKNSSCYFLGDATNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
297CYFLGDATNDSLQRVUniProt;curated19779198; 22817900
381RGYEEVITPNMYNSKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
393NSKLWETSGHWANYKcurated24961812
453VIHRNEFSGALSGLTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22817900
457NEFSGALSGLTRVRRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22369663;
460SGALSGLTRVRRFQQdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MSASEAGVTE QVKKLSVKDS SNDAVKPNKK ENKKSKQQSL YLDPEPTFIE ERIEMFDRLQ 60
KEYNDKVASM PRVPLKIVLK DGAVKEATSW ETTPMDIAKG ISKSLADRLC ISKVNGQLWD 120
LDRPFEGEAN EEIKLELLDF ESDEGKKVFW HSSAHVLGES CECHLGAHIC LGPPTDDGFF 180
YEMAVRDSMK DISESPERTV SQADFPGLEG VAKNVIKQKQ KFERLVMSKE DLLKMFHYSK 240
YKTYLVQTKV PDGGATTVYR CGKLIDLCVG PHIPHTGRIK AFKLLKNSSC YFLGDATNDS 300
LQRVYGISFP DKKLMDAHLK FLAEASMRDH RKIGKEQELF LFNEMSPGSC FWLPHGTRIY 360
NTLVDLLRTE YRKRGYEEVI TPNMYNSKLW ETSGHWANYK ENMFTFEVEK ETFGLKPMNC 420
PGHCLMFKSR ERSYRELPWR VADFGVIHRN EFSGALSGLT RVRRFQQDDA HIFCTHDQIE 480
SEIENIFNFL QYIYGVFGFE FKMELSTRPE KYVGKIETWD AAESKLESAL KKWGGNWEIN 540
AGDGAFYGPK IDIMISDALR RWHQCATIQL DFQLPNRFEL EFKSKDQDSE SYERPVMIHR 600
AILGSVERMT AILTEHFAGK WPFWLSPRQV LVVPVGVKYQ GYAEDVRNKL HDAGFYADVD 660
LTGNTLQKKV RNGQMLKYNF IFIVGEQEMN EKSVNIRNRD VMEQQGKNAT VSVEEVLKQL 720
RNLKDEKRGD NVLA 735
Keyword

KW-0030--Aminoacyl-tRNA synthetase
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
Interpro

IPR002314--aa-tRNA-synt_IIb
IPR006195--aa-tRNA-synth_II
IPR004154--Anticodon-bd
IPR012675--Beta-grasp_dom
IPR004095--TGS
IPR012676--TGS-like
IPR002320--Thr-tRNA-ligase_IIa
IPR018163--Thr/Ala-tRNA-synth_IIc_edit
IPR012947--tRNA_SAD
PROSITE

PS50862--AA_TRNA_LIGASE_II
Pfam

PF03129--HGTP_anticodon
PF02824--TGS
PF00587--tRNA-synt_2b
PF07973--tRNA_SAD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004829--F:threonine-tRNA ligase activity
GO:0002181--P:cytoplasmic translation
GO:0006435--P:threonyl-tRNA aminoacylation