Functional Description
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).Functional Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). |
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0000790--C:nuclear chromatin
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0043234--C:protein complex
GO:0005657--C:replication fork
GO:0005524--F:ATP binding
GO:0051087--F:chaperone binding
GO:0003682--F:chromatin binding
GO:0005507--F:copper ion binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003684--F:damaged DNA binding
GO:0003677--F:DNA binding
GO:0003690--F:double-stranded DNA binding
GO:0019899--F:enzyme binding
GO:0035035--F:histone acetyltransferase binding
GO:0035033--F:histone deacetylase regulator activity
GO:0042802--F:identical protein binding
GO:0002039--F:p53 binding
GO:0002020--F:protease binding
GO:0046982--F:protein heterodimerization activity
GO:0019901--F:protein kinase binding
GO:0047485--F:protein N-terminus binding
GO:0051721--F:protein phosphatase 2A binding
GO:0019903--F:protein phosphatase binding
GO:0043621--F:protein self-association
GO:0030971--F:receptor tyrosine kinase binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0002326--P:B cell lineage commitment
GO:0006284--P:base-excision repair
GO:0007596--P:blood coagulation
GO:0007569--P:cell aging
GO:0007050--P:cell cycle arrest
GO:0030154--P:cell differentiation
GO:0008283--P:cell proliferation
GO:0034613--P:cellular protein localization
GO:0006974--P:cellular response to DNA damage stimulus
GO:0035690--P:cellular response to drug
GO:0042149--P:cellular response to glucose starvation
GO:0071456--P:cellular response to hypoxia
GO:0071479--P:cellular response to ionizing radiation
GO:0034644--P:cellular response to UV
GO:0071494--P:cellular response to UV-C
GO:0021549--P:cerebellum development
GO:0031497--P:chromatin assembly
GO:0031052--P:chromosome breakage
GO:0048512--P:circadian behavior
GO:0008340--P:determination of adult lifespan
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006281--P:DNA repair
GO:0000733--P:DNA strand renaturation
GO:0006302--P:double-strand break repair
GO:0048568--P:embryonic organ development
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0006983--P:ER overload response
GO:0007369--P:gastrulation
GO:0010467--P:gene expression
GO:0001701--P:in utero embryonic development
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990144--P:intrinsic apoptotic signaling pathway in response to hypoxia
GO:0043504--P:mitochondrial DNA repair
GO:0071850--P:mitotic cell cycle arrest
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0035264--P:multicellular organism growth
GO:0007275--P:multicellular organismal development
GO:0070266--P:necroptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0008156--P:negative regulation of DNA replication
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1904024--P:negative regulation of glucose catabolic process to lactate via pyruvate
GO:0051097--P:negative regulation of helicase activity
GO:1901525--P:negative regulation of macromitophagy
GO:0007406--P:negative regulation of neuroblast proliferation
GO:0045861--P:negative regulation of proteolysis
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051402--P:neuron apoptotic process
GO:0007219--P:Notch signaling pathway
GO:0006289--P:nucleotide-excision repair
GO:0097252--P:oligodendrocyte apoptotic process
GO:0090403--P:oxidative stress-induced premature senescence
GO:0043065--P:positive regulation of apoptotic process
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0071158--P:positive regulation of cell cycle arrest
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0010628--P:positive regulation of gene expression
GO:0031065--P:positive regulation of histone deacetylation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0035794--P:positive regulation of mitochondrial membrane permeability
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:1900740--P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461--P:positive regulation of protein oligomerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0070245--P:positive regulation of thymocyte apoptotic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1990440--P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0061419--P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0012501--P:programmed cell death
GO:0006461--P:protein complex assembly
GO:0000060--P:protein import into nucleus, translocation
GO:0008104--P:protein localization
GO:0051262--P:protein tetramerization
GO:0007265--P:Ras protein signal transduction
GO:0042981--P:regulation of apoptotic process
GO:2000772--P:regulation of cellular senescence
GO:2000269--P:regulation of fibroblast apoptotic process
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:1902253--P:regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:0046902--P:regulation of mitochondrial membrane permeability
GO:1902108--P:regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0034103--P:regulation of tissue remodeling
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001836--P:release of cytochrome c from mitochondria
GO:0090399--P:replicative senescence
GO:0046677--P:response to antibiotic
GO:0010332--P:response to gamma radiation
GO:0002931--P:response to ischemia
GO:0009651--P:response to salt stress
GO:0010165--P:response to X-ray
GO:0009303--P:rRNA transcription
GO:0001756--P:somitogenesis
GO:0033077--P:T cell differentiation in thymus
GO:0002360--P:T cell lineage commitment
GO:0002309--P:T cell proliferation involved in immune response
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0016032--P:viral process
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