dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004157
Uniprot Accession P04197; MYB_DROME; Q9VXM9;
Genbank Protein ID NP_511170.1; NP_996454.1; NP_996456.1; NP_996457.1;
Genbank Nucleotide ID NM_078615.4; NM_206731.2; NM_206733.2; NM_206734.2;
Protein Name Myb protein
Protein Synonyms/Alias
Gene Name Myb
Gene Synonyms/Alias CG9045;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
53DSGYPLDSPELQDSKPHOSIDA;curated21081558; 22817900
376NARSRPPSSPVISPIPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
377ARSRPPSSPVISPIKPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
381PPSSPVISPIKSLPFdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 22817900
389PIKSLPFSPSHFLKSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
391KSLPFSPSHFLKSPCPHOSIDA;curated21081558; 22817900
396SPSHFLKSPCLTTFEdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;UniProt18327897; 16381945; 23193290; 19060867
445KSQLGPRTPTPFKKAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
447QLGPRTPTPFKKALAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
469GRRYEPSSPSSLVEDPhosphoPep 2.0;curated19060867; 22817900
557ETPSKFLTSPGDILKdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
558TPSKFLTSPGDILKDdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
566PGDILKDTLCSEQDLdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
569ILKDTLCSEQDLPFDdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MASASTENGE ELMNYGSNSD SEESEYSENE DTQVCDKDSQ QNSNADSGYP LDSPELQDSK 60
TTGQKGQNKS GKTSIGAVHP NYGFGKRWSK SEDVLLKQLV ETHGENWEII GPHFKDRLEQ 120
QVQQRWAKVL NPELIKGPWT RDEDDMVIKL VRNFGPKKWT LIARYLNGRI GKQCRERWHN 180
HLNPNIKKTA WTEKEDEIIY QAHLELGNQW AKIAKRLPGR TDNAIKNHWN STMRRKYDVE 240
RRSVNASGSD LKSSRTHLIT LIKSGGISKC MNNMQHNKES GGEAVNKSEN ADGASVTAVK 300
GGDLAQESQD DHQKGSNLAH LSMQHLIKLT MPRQTPIILK RTRKHIPETH HQAGCSSSET 360
FNQEEAAGNA RSRPPSSPVI SPIKSLPFSP SHFLKSPCLT TFEDMDLRAS TPVTKVYNRV 420
GMEIKKEMET SSIETPHKSQ LGPRTPTPFK KALAAIGKKR DGRRYEPSSP SSLVEDLAEI 480
IHEEHLSNSL TANNSKMMGA ADQNSTLSTE YNAQSPPHMK RARKSLLSTW SSNHPYNAGS 540
AKRIQPFETE TPSKFLTSPG DILKDTLCSE QDLPFDEGRK ENRPFHNRRI NKYRGGLTYD 600
HVIDPKWARV ACGKSRDQMF MEEQAYACLK NLSCISRSLN FEKQKCLVNS FDRFGSL 658
Keyword

KW-0010--Activator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR015395--C-myb_C
IPR009057--Homeodomain-like
IPR017877--Myb-like_dom
IPR017930--Myb_dom
IPR001005--SANT/Myb
PROSITE

PS51294--HTH_MYB
Pfam

PF09316--Cmyb_C
PF00249--Myb_DNA-binding
Gene Ontology

GO:0031523--C:Myb complex
GO:0005719--C:nuclear euchromatin
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008283--P:cell proliferation
GO:0007099--P:centriole replication
GO:0007098--P:centrosome cycle
GO:0051297--P:centrosome organization
GO:0030261--P:chromosome condensation
GO:0007307--P:eggshell chorion gene amplification
GO:0007030--P:Golgi organization
GO:0000278--P:mitotic cell cycle
GO:0000281--P:mitotic cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0090307--P:mitotic spindle assembly
GO:0007052--P:mitotic spindle organization
GO:0045792--P:negative regulation of cell size
GO:0008284--P:positive regulation of cell proliferation
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0090282--P:positive regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0007088--P:regulation of mitotic nuclear division
GO:0007051--P:spindle organization
GO:0006366--P:transcription from RNA polymerase II promoter