dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004079
Uniprot Accession P03069; GCN4_YEAST; D3DLN9; P03068; Q70D88; Q70D91; Q70D96; Q70D99; Q70DA0; Q96UT3;
Genbank Protein ID NP_010907.3;
Genbank Nucleotide ID NM_001178824.3;
Protein Name General control protein GCN4
Protein Synonyms/Alias Amino acid biosynthesis regulatory protein;
Gene Name GCN4
Gene Synonyms/Alias AAS3;ARG9;YEL009C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
17ALNPMGFSPLDGSKSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 11331604; 19366988
61DPIIKQDTPSNLDFDPhosphoGRID 2.0;curated11331604; 24961812
105FSSSTDSTPMFEYENPhosphoGRID 2.012101234; 11331604
165STTSFLPTPVLEDAKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated12101234; 18407956; 16381945; 23193290; 10712509; 11331604;
214AYNRKQRSIPLSPIVcurated24961812
218KQRSIPLSPIVPESSdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 11331604; 21081558; 19366988;
Sequence
(Fasta)
MSEYQPSLFA LNPMGFSPLD GSKSTNENVS ASTSTAKPMV GQLIFDKFIK TEEDPIIKQD 60
TPSNLDFDFA LPQTATAPDA KTVLPIPELD DAVVESFFSS STDSTPMFEY ENLEDNSKEW 120
TSLFDNDIPV TTDDVSLADK AIESTEEVSL VPSNLEVSTT SFLPTPVLED AKLTQTRKVK 180
KPNSVVKKSH HVGKDDESRL DHLGVVAYNR KQRSIPLSPI VPESSDPAAL KRARNTEAAR 240
RSRARKLQRM KQLEDKVEEL LSKNYHLENE VARLKKLVGE R 282
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0028--Amino-acid biosynthesis
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR004827--bZIP

PROSITE

PS50217--BZIP
PS00036--BZIP_BASIC

Pfam

PF07716--bZIP_2

Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0042802--F:identical protein binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001135--F:transcription factor activity, RNA polymerase II transcription factor recruiting
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001084--F:transcription factor activity, TFIID-class binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0008652--P:cellular amino acid biosynthetic process
GO:0010691--P:negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001080--P:nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:1903833--P:positive regulation of cellular response to amino acid starvation
GO:0045899--P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0060261--P:positive regulation of transcription initiation from RNA polymerase II promoter
GO:0010033--P:response to organic substance
GO:0006366--P:transcription from RNA polymerase II promoter