| Tag |
Content |
| dbPAF ID |
dbPAF-0004077 |
| Uniprot Accession |
P02992; EFTU_YEAST; D6W2P3;
|
| Genbank Protein ID |
NP_014830.1;
|
| Genbank Nucleotide ID |
NM_001183606.1;
|
| Protein Name |
Elongation factor Tu, mitochondrial |
| Protein Synonyms/Alias |
tufM; |
| Gene Name |
TUF1 |
| Gene Synonyms/Alias |
TUFM;YOR187W; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA.Functional Description
G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MSALLPRLLT RTAFKASGKL LRLSSVISRT FSQTTTSYAA AFDRSKPHVN IGTIGHVDHG 60
KTTLTAAITK TLAAKGGANF LDYAAIDKAP EERARGITIS TAHVEYETAK RHYSHVDCPG 120
HADYIKNMIT GAAQMDGAII VVAATDGQMP QTREHLLLAR QVGVQHIVVF VNKVDTIDDP 180
EMLELVEMEM RELLNEYGFD GDNAPIIMGS ALCALEGRQP EIGEQAIMKL LDAVDEYIPT 240
PERDLNKPFL MPVEDIFSIS GRGTVVTGRV ERGNLKKGEE LEIVGHNSTP LKTTVTGIEM 300
FRKELDSAMA GDNAGVLLRG IRRDQLKRGM VLAKPGTVKA HTKILASLYI LSKEEGGRHS 360
GFGENYRPQM FIRTADVTVV MRFPKEVEDH SMQVMPGDNV EMECDLIHPT PLEVGQRFNI 420
REGGRTVGTG LITRIIE
438Fasta Sequence
>P02992|TUF1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSALLPRLLTRTAFKASGKLLRLSSVISRTFSQTTTSYAAAFDRSKPHVNIGTIGHVDHGKTTLTAAITKTLAAKGGANFLDYAAIDKAPEERARGITISTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGVQHIVVFVNKVDTIDDPEMLELVEMEMRELLNEYGFDGDNAPIIMGSALCALEGRQPEIGEQAIMKLLDAVDEYIPTPERDLNKPFLMPVEDIFSISGRGTVVTGRVERGNLKKGEELEIVGHNSTPLKTTVTGIEMFRKELDSAMAGDNAGVLLRGIRRDQLKRGMVLAKPGTVKAHTKILASLYILSKEEGGRHSGFGENYRPQMFIRTADVTVVMRFPKEVEDHSMQVMPGDNVEMECDLIHPTPLEVGQRFNIREGGRTVGTGLITRIIE
|
| Keyword |
KW-0181--Complete proteome
KW-0251--Elongation factor
KW-0342--GTP-binding
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0809--Transit peptide
|
| Interpro |
IPR031157--G_TR_CS
IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR000795--TF_GTP-bd_dom
IPR009000--Transl_B-barrel
IPR009001--Transl_elong_EF1A/Init_IF2_C
IPR004161--Transl_elong_EFTu/EF1A_2
IPR004541--Transl_elong_EFTu/EF1A_bac/org
IPR004160--Transl_elong_EFTu/EF1A_C
|
| PROSITE |
PS00301--G_TR_1
PS51722--G_TR_2
|
| Pfam |
PF03144--GTP_EFTU_D2
PF03143--GTP_EFTU_D3
|
| Gene Ontology |
GO:0005739--C:mitochondrion
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0003746--F:translation elongation factor activity
GO:0032543--P:mitochondrial translation
GO:0070125--P:mitochondrial translational elongation
|
