| Tag |
Content |
| dbPAF ID |
dbPAF-0004074 |
| Uniprot Accession |
P02836; HMEN_DROME; P02837; Q0E9C0; Q24356; Q9V601;
|
| Genbank Protein ID |
NP_523700.2; NP_725059.1;
|
| Genbank Nucleotide ID |
NM_078976.4; NM_165841.2;
|
| Protein Name |
Segmentation polarity homeobox protein engrailed |
| Protein Synonyms/Alias |
|
| Gene Name |
en |
| Gene Synonyms/Alias |
CG9015; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.Functional Description
This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MALEDRCSPQ SAPSPITLQM QHLHHQQQQQ QQQQQQMQHL HQLQQLQQLH QQQLAAGVFH 60
HPAMAFDAAA AAAAAAAAAA AHAHAAALQQ RLSGSGSPAS CSTPASSTPL TIKEEESDSV 120
IGDMSFHNQT HTTNEEEEAE EDDDIDVDVD DTSAGGRLPP PAHQQQSTAK PSLAFSISNI 180
LSDRFGDVQK PGKSMENQAS IFRPFEASRS QTATPSAFTR VDLLEFSRQQ QAAAAAATAA 240
MMLERANFLN CFNPAAYPRI HEEIVQSRLR RSAANAVIPP PMSSKMSDAN PEKSALGSLC 300
KAVSQIGQPA APTMTQPPLS SSASSLASPP PASNASTISS TSSVATSSSS SSSGCSSAAS 360
SLNSSPSSRL GASGSGVNAS SPQPQPIPPP SAVSRDSGME SSDDTRSETG STTTEGGKNE 420
MWPAWVYCTR YSDRPSSGPR YRRPKQPKDK TNDEKRPRTA FSSEQLARLK REFNENRYLT 480
ERRRQQLSSE LGLNEAQIKI WFQNKRAKIK KSTGSKNPLA LQLMAQGLYN HTTVPLTKEE 540
EELEMRMNGQ IP
553Fasta Sequence
>P02836|en|Drosophila melanogaster(Fruit fly)
MALEDRCSPQSAPSPITLQMQHLHHQQQQQQQQQQQMQHLHQLQQLQQLHQQQLAAGVFHHPAMAFDAAAAAAAAAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSVIGDMSFHNQTHTTNEEEEAEEDDDIDVDVDDTSAGGRLPPPAHQQQSTAKPSLAFSISNILSDRFGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEELEMRMNGQIP
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0709--Segmentation polarity protein
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR019549--Homeobox-engrailed_C-terminal
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR020479--Homeobox_metazoa
IPR009057--Homeodomain-like
IPR000747--Homeodomain_engrailed
IPR019737--Homoebox-engrailed_CS
IPR000047--HTH_motif
|
| PROSITE |
PS00033--ENGRAILED
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
|
| Pfam |
PF10525--Engrail_1_C_sig
PF00046--Homeobox
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0001158--F:enhancer sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0007487--P:analia development
GO:0021960--P:anterior commissure morphogenesis
GO:0035288--P:anterior head segmentation
GO:0048099--P:anterior/posterior lineage restriction, imaginal disc
GO:0007448--P:anterior/posterior pattern specification, imaginal disc
GO:0007411--P:axon guidance
GO:0007386--P:compartment pattern specification
GO:0035224--P:genital disc anterior/posterior pattern formation
GO:0035215--P:genital disc development
GO:0008406--P:gonad development
GO:0007447--P:imaginal disc pattern formation
GO:0007486--P:imaginal disc-derived female genitalia development
GO:0007485--P:imaginal disc-derived male genitalia development
GO:0007474--P:imaginal disc-derived wing vein specification
GO:0010629--P:negative regulation of gene expression
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007400--P:neuroblast fate determination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007388--P:posterior compartment specification
GO:0035289--P:posterior head segmentation
GO:0010468--P:regulation of gene expression
GO:0007367--P:segment polarity determination
GO:0035277--P:spiracle morphogenesis, open tracheal system
GO:0006351--P:transcription, DNA-templated
GO:0035290--P:trunk segmentation
GO:0007418--P:ventral midline development
GO:0048100--P:wing disc anterior/posterior pattern formation
|
