dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004070
Uniprot Accession P02828; HSP83_DROME; P92174; P92202; Q9VZT3;
Genbank Protein ID NP_001261362.1; NP_523899.1;
Genbank Nucleotide ID NM_001274433.1; NM_079175.4;
Protein Name Heat shock protein 83
Protein Synonyms/Alias HSP 82;
Gene Name Hsp83
Gene Synonyms/Alias Hsp82;CG1242;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins.
Phosphorylation Sites
dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
87IDTGIGMTKSDLVNNPhosphoPep 2.019060867
89TGIGMTKSDLVNNLGPhosphoPep 2.0;curated19060867; 22817900
219KEREKEVSDDEADDEdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17372656; 16381945; 23193290; 18327897; 21081558; 19060867;
238DEKKEMETDEPKIEDPhosphoPep 2.019060867
278EDEELNKTKPIWTRNdbPTM 3.0;PhosphoPep 2.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
294DDISQEEYGEFYKSLdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
332LLFIPRRTPFDLFENdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
384EDLPLNISREMLQQNdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
405RKNLVKKTMELIEELPhosphoPep 2.019060867
438KLGVHEDSNNRAKLAPHOSIDA;curated21081558; 22817900
607KAQALRDTATMGYMAcurated22817900
612RDTATMGYMAGKKQLcurated22817900
696MTTDDAQSAGDAPSLPHOSIDA;curated21081558; 22817900
702QSAGDAPSLVEDTEDPhosphoPep 2.019060867
711VEDTEDASHMEEVD-PhosphoPep 2.0;curated19060867; 22817900
Sequence
(Fasta)
MPEEAETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNA SDALDKIRYE SLTDPSKLDS 60
GKELYIKLIP NKTAGTLTII DTGIGMTKSD LVNNLGTIAK SGTKAFMEAL QAGADISMIG 120
QFGVGFYSAY LVADKVTVTS KNNDDEQYVW ESSAGGSFTV RADNSEPLGR GTKIVLYIKE 180
DQTDYLEESK IKEIVNKHSQ FIGYPIKLLV EKEREKEVSD DEADDEKKEG DEKKEMETDE 240
PKIEDVGEDE DADKKDKDAK KKKTIKEKYT EDEELNKTKP IWTRNPDDIS QEEYGEFYKS 300
LTNDWEDHLA VKHFSVEGQL EFRALLFIPR RTPFDLFENQ KKRNNIKLYV RRVFIMDNCE 360
DLIPEYLNFM KGVVDSEDLP LNISREMLQQ NKVLKVIRKN LVKKTMELIE ELTEDKENYK 420
KFYDQFSKNL KLGVHEDSNN RAKLADFLRF HTSASGDDFC SLADYVSRMK DNQKHVYFIT 480
GESKDQVSNS AFVERVKARG FEVVYMTEPI DEYVIQHLKE YKGKQLVSVT KEGLELPEDE 540
SEKKKREEDK AKFESLCKLM KSILDNKVEK VVVSNRLVDS PCCIVTSQFG WSANMERIMK 600
AQALRDTATM GYMAGKKQLE INPDHPIVET LRQKADADKN DKAVKDLVIL LFETSLLSSG 660
FSLDSPQVHA SRIYRMIKLG LGIDEDEPMT TDDAQSAGDA PSLVEDTEDA SHMEEVD 718
Keyword

KW-0067--ATP-binding
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response

Interpro

IPR003594--HATPase_C
IPR019805--Heat_shock_protein_90_CS
IPR001404--Hsp90_fam
IPR020575--Hsp90_N
IPR020568--Ribosomal_S5_D2-typ_fold

PROSITE

PS00298--HSP90

Pfam

PF02518--HATPase_c
PF00183--HSP90

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005811--C:lipid particle
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005705--C:polytene chromosome interband
GO:0005524--F:ATP binding
GO:0051082--F:unfolded protein binding
GO:0007015--P:actin filament organization
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0007098--P:centrosome cycle
GO:0009631--P:cold acclimation
GO:0007052--P:mitotic spindle organization
GO:0008285--P:negative regulation of cell proliferation
GO:0010529--P:negative regulation of transposition
GO:0048477--P:oogenesis
GO:0019094--P:pole plasm mRNA localization
GO:0043248--P:proteasome assembly
GO:0006457--P:protein folding
GO:0007465--P:R7 cell fate commitment
GO:0008360--P:regulation of cell shape
GO:0045187--P:regulation of circadian sleep/wake cycle, sleep
GO:0009408--P:response to heat
GO:0007283--P:spermatogenesis
GO:0008293--P:torso signaling pathway