dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004005
Uniprot Accession P02557; TBB_YEAST; D6VTJ3;
Genbank Protein ID NP_116616.1;
Genbank Nucleotide ID NM_001179929.1;
Protein Name Tubulin beta chain
Protein Synonyms/Alias Beta-tubulin;
Gene Name TUB2
Gene Synonyms/Alias YFL037W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
115EGAELVDSVMDVIRRPhosphoPep 2.019060867
278APLTAIGSQSFRSLTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 22369663
280LTAIGSQSFRSLTVPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 26040406
Sequence
(Fasta)
MREIIHISTG QCGNQIGAAF WETICGEHGL DFNGTYHGHD DIQKERLNVY FNEASSGKWV 60
PRSINVDLEP GTIDAVRNSA IGNLFRPDNY IFGQSSAGNV WAKGHYTEGA ELVDSVMDVI 120
RREAEGCDSL QGFQITHSLG GGTGSGMGTL LISKIREEFP DRMMATFSVL PSPKTSDTVV 180
EPYNATLSVH QLVEHSDETF CIDNEALYDI CQRTLKLNQP SYGDLNNLVS SVMSGVTTSL 240
RYPGQLNSDL RKLAVNLVPF PRLHFFMVGY APLTAIGSQS FRSLTVPELT QQMFDAKNMM 300
AAADPRNGRY LTVAAFFRGK VSVKEVEDEM HKVQSKNSDY FVEWIPNNVQ TAVCSVAPQG 360
LDMAATFIAN STSIQELFKR VGDQFSAMFK RKAFLHWYTS EGMDELEFSE AESNMNDLVS 420
EYQQYQEATV EDDEEVDENG DFGAPQNQDE PITENFE 458
Keyword

KW-0002--3D-structure
KW-0046--Antibiotic resistance
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0342--GTP-binding
KW-0493--Microtubule
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR013838--Beta-tubulin_BS
IPR002453--Beta_tubulin
IPR008280--Tub_FtsZ_C
IPR000217--Tubulin
IPR018316--Tubulin/FtsZ_2-layer-sand-dom
IPR023123--Tubulin_C
IPR017975--Tubulin_CS
IPR003008--Tubulin_FtsZ_GTPase

PROSITE

PS00227--TUBULIN
PS00228--TUBULIN_B_AUTOREG

Pfam

PF00091--Tubulin
PF03953--Tubulin_C

Gene Ontology

GO:0005881--C:cytoplasmic microtubule
GO:0005828--C:kinetochore microtubule
GO:0005880--C:nuclear microtubule
GO:0005816--C:spindle pole body
GO:0045298--C:tubulin complex
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0005200--F:structural constituent of cytoskeleton
GO:0045143--P:homologous chromosome segregation
GO:0000070--P:mitotic sister chromatid segregation
GO:0030473--P:nuclear migration along microtubule
GO:0051258--P:protein polymerization
GO:0046677--P:response to antibiotic