Functional Description
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).Functional Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). |
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0000790--C:nuclear chromatin
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0043234--C:protein complex
GO:0005657--C:replication fork
GO:0035861--C:site of double-strand break
GO:0005667--C:transcription factor complex
GO:0005524--F:ATP binding
GO:0051087--F:chaperone binding
GO:0003682--F:chromatin binding
GO:0005507--F:copper ion binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003684--F:damaged DNA binding
GO:0003677--F:DNA binding
GO:0003690--F:double-stranded DNA binding
GO:0019899--F:enzyme binding
GO:0035035--F:histone acetyltransferase binding
GO:0035033--F:histone deacetylase regulator activity
GO:0042802--F:identical protein binding
GO:0097371--F:MDM2/MDM4 family protein binding
GO:0002039--F:p53 binding
GO:0002020--F:protease binding
GO:0046982--F:protein heterodimerization activity
GO:0019901--F:protein kinase binding
GO:0047485--F:protein N-terminus binding
GO:0051721--F:protein phosphatase 2A binding
GO:0019903--F:protein phosphatase binding
GO:0043621--F:protein self-association
GO:0030971--F:receptor tyrosine kinase binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0006915--P:apoptotic process
GO:0002326--P:B cell lineage commitment
GO:0060411--P:cardiac septum morphogenesis
GO:0007569--P:cell aging
GO:0007050--P:cell cycle arrest
GO:0034613--P:cellular protein localization
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042149--P:cellular response to glucose starvation
GO:0071479--P:cellular response to ionizing radiation
GO:0034644--P:cellular response to UV
GO:0071494--P:cellular response to UV-C
GO:0007417--P:central nervous system development
GO:0021549--P:cerebellum development
GO:0031497--P:chromatin assembly
GO:0031052--P:chromosome breakage
GO:0051276--P:chromosome organization
GO:0048512--P:circadian behavior
GO:0007623--P:circadian rhythm
GO:0008340--P:determination of adult lifespan
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000733--P:DNA strand renaturation
GO:0006302--P:double-strand break repair
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0048568--P:embryonic organ development
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0006983--P:ER overload response
GO:0007369--P:gastrulation
GO:0007507--P:heart development
GO:0001701--P:in utero embryonic development
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1990144--P:intrinsic apoptotic signaling pathway in response to hypoxia
GO:0043504--P:mitochondrial DNA repair
GO:0071850--P:mitotic cell cycle arrest
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0035264--P:multicellular organism growth
GO:0007275--P:multicellular organismal development
GO:0070266--P:necroptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0008156--P:negative regulation of DNA replication
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1904024--P:negative regulation of glucose catabolic process to lactate via pyruvate
GO:1901525--P:negative regulation of macromitophagy
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007406--P:negative regulation of neuroblast proliferation
GO:0045861--P:negative regulation of proteolysis
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051402--P:neuron apoptotic process
GO:0006289--P:nucleotide-excision repair
GO:0097252--P:oligodendrocyte apoptotic process
GO:0090403--P:oxidative stress-induced premature senescence
GO:0043065--P:positive regulation of apoptotic process
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0090343--P:positive regulation of cell aging
GO:0071158--P:positive regulation of cell cycle arrest
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0010628--P:positive regulation of gene expression
GO:0031065--P:positive regulation of histone deacetylation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0035794--P:positive regulation of mitochondrial membrane permeability
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0032461--P:positive regulation of protein oligomerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0070245--P:positive regulation of thymocyte apoptotic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1990440--P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0061419--P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006461--P:protein complex assembly
GO:0000060--P:protein import into nucleus, translocation
GO:0008104--P:protein localization
GO:0051262--P:protein tetramerization
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:0042127--P:regulation of cell proliferation
GO:2000772--P:regulation of cellular senescence
GO:2000269--P:regulation of fibroblast apoptotic process
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:1902253--P:regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902108--P:regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0043523--P:regulation of neuron apoptotic process
GO:0070243--P:regulation of thymocyte apoptotic process
GO:0034103--P:regulation of tissue remodeling
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001836--P:release of cytochrome c from mitochondria
GO:0090399--P:replicative senescence
GO:0042493--P:response to drug
GO:0010332--P:response to gamma radiation
GO:0002931--P:response to ischemia
GO:0006979--P:response to oxidative stress
GO:0009651--P:response to salt stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0009303--P:rRNA transcription
GO:0001756--P:somitogenesis
GO:0033077--P:T cell differentiation in thymus
GO:0002360--P:T cell lineage commitment
GO:0002309--P:T cell proliferation involved in immune response
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0016032--P:viral process
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