dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003977
Uniprot Accession P02309; H4_YEAST; D6VQ10;
Genbank Protein ID NP_009563.1; NP_014368.1;
Genbank Nucleotide ID NM_001178357.1; NM_001182869.1;
Protein Name Histone H4
Protein Synonyms/Alias
Gene Name HHF2
Gene Synonyms/Alias YBR009C;YBR0122;YNL030W;N2752;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
2------MSGRGKGGKPhosphoGRID 2.016980586; 15823538; 16135807
48RGGVKRISGLIYEEVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 22369663;
61EVRAVLKSFLESVIRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20190278; 19779198; 19366988;
65VLKSFLESVIRDSVTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 20190278; 19779198; 19366988;
97ALKRQGRTLYGFGG-curated22817900; 19547744
Sequence
(Fasta)		MSGRGKGGKG LGKGGAKRHR KILRDNIQGI TKPAIRRLAR RGGVKRISGL IYEEVRAVLK 60
SFLESVIRDS VTYTEHAKRK TVTSLDVVYA LKRQGRTLYG FGG 104
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR009072--Histone-fold
IPR001951--Histone_H4
IPR019809--Histone_H4_CS
PROSITE

PS00047--HISTONE_H4
Pfam
Gene Ontology

GO:0000788--C:nuclear nucleosome
GO:0031298--C:replication fork protection complex
GO:0003677--F:DNA binding
GO:0006333--P:chromatin assembly or disassembly
GO:0034729--P:histone H3-K79 methylation
GO:0006334--P:nucleosome assembly
GO:0043935--P:sexual sporulation resulting in formation of a cellular spore
GO:0061587--P:transfer RNA gene-mediated silencing