dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003975
Uniprot Accession P02299; H3_DROME; Q4ABE4;
Genbank Protein ID NP_001027285.1; NP_001027289.1; NP_001027294.1; NP_001027298.1; NP_001027303.1; NP_001027308.1; NP_001027313.1; NP_001027318.1; NP_001027323.1; NP_001027328.1; NP_001027333.1; NP_001027338.1; NP_001027343.1; NP_001027348.1; NP_001027353.1; NP_001027358.1; NP_001027363.1; NP_001027368.1; NP_001027373.1; NP_001027378.1; NP_001027383.1; NP_001027387.1; NP_724345.1;
Genbank Nucleotide ID NM_001032114.2; NM_001032118.2; NM_001032123.2; NM_001032127.2; NM_001032132.2; NM_001032137.2; NM_001032142.2; NM_001032147.2; NM_001032152.2; NM_001032157.2; NM_001032162.2; NM_001032167.2; NM_001032172.2; NM_001032177.2; NM_001032182.2; NM_001032187.2; NM_001032192.2; NM_001032197.2; NM_001032202.2; NM_001032207.2; NM_001032212.2; NM_001032216.2; NM_165384.3;
Protein Name Histone H3
Protein Synonyms/Alias
Gene Name His3:CG33866
Gene Synonyms/Alias CG31613;CG33803;CG33806;CG33809;CG33812;CG33815;CG33818;CG33821;CG33824;CG33827;CG33830;CG33833;CG33836;CG33839;CG33842;CG33845;CG33848;CG33851;CG33854;CG33857;CG33860;CG33863;CG33866;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
11TKQTARKSTGGKAPRdbPTM 3.0;Phospho.ELM 9.0;UniProt11114889; 11266459; 11371341; 12514098; 15175259; 16381945;
29ATKAARKSAPATGGVPhosphoPep 2.0;curated19060867; 22817900
Sequence
(Fasta)		MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE 60
LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY LVGLFEDTNL CAIHAKRVTI 120
MPKDIQLARR IRGERA 137
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0488--Methylation
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR009072--Histone-fold
IPR007125--Histone_H2A/H2B/H3
IPR000164--Histone_H3/CENP-A
PROSITE

PS00322--HISTONE_H3_1
PS00959--HISTONE_H3_2
Pfam

PF00125--Histone
Gene Ontology

GO:0000786--C:nucleosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding