dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003974
Uniprot Accession P02294; H2B2_YEAST; D6VQ00;
Genbank Protein ID NP_009553.1;
Genbank Nucleotide ID NM_001178242.1;
Protein Name Histone H2B.2
Protein Synonyms/Alias
Gene Name HTB2
Gene Synonyms/Alias H2B2;YBL002W;YBL0104;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
11AAEKKPASKAPAEKKdbPTM 3.0;UniProt15652479; 15970663; 16381945; 23193290
25KPAAKKTSTSVDGKKcurated25315811
27AAKKTSTSVDGKKRSPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19060867; 22817900; 25315811
40RSKVRKETYSSYIYKdbPTM 3.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
41SKVRKETYSSYIYKVPhosphoGRID 2.017287358
42KVRKETYSSYIYKVLdbPTM 3.0;PhosphoGRID 2.018407956; 16381945; 23193290
Sequence
(Fasta)		MSSAAEKKPA SKAPAEKKPA AKKTSTSVDG KKRSKVRKET YSSYIYKVLK QTHPDTGISQ 60
KSMSILNSFV NDIFERIATE ASKLAAYNKK STISAREIQT AVRLILPGEL AKHAVSEGTR 120
AVTKYSSSTQ A 132
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR009072--Histone-fold
IPR007125--Histone_H2A/H2B/H3
IPR000558--Histone_H2B
PROSITE

PS00357--HISTONE_H2B
Pfam

PF00125--Histone
Gene Ontology

GO:0000788--C:nuclear nucleosome
GO:0031298--C:replication fork protection complex
GO:0003677--F:DNA binding
GO:0006333--P:chromatin assembly or disassembly
GO:0006334--P:nucleosome assembly