dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003973
Uniprot Accession P02293; H2B1_YEAST; D6VSK6;
Genbank Protein ID NP_010510.3;
Genbank Nucleotide ID NM_001180532.3;
Protein Name Histone H2B.1
Protein Synonyms/Alias Suppressor of Ty protein 12;
Gene Name HTB1
Gene Synonyms/Alias H2B1;SPT12;YDR224C;YD9934.09C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
11KAEKKPASKAPAEKKdbPTM 3.0;PhosphoGRID 2.0;UniProt15652479; 15970663; 16381945; 23193290
40RSKARKETYSSYIYKcurated22817900; 20377248; 19547744
42KARKETYSSYIYKVLSysPTM 2.0;curated18407956; 19366988; 22817900; 24961812; 20377248
43ARKETYSSYIYKVLKcurated22817900
44RKETYSSYIYKVLKQcurated22817900
62DTGISQKSMSILNSFPhosphoGRID 2.0;curated19779198; 22817900
129VTKYSSSTQA-----PhosphoGRID 2.0;curated20190278; 26040406; 25521595
Sequence
(Fasta)		MSAKAEKKPA SKAPAEKKPA AKKTSTSTDG KKRSKARKET YSSYIYKVLK QTHPDTGISQ 60
KSMSILNSFV NDIFERIATE ASKLAAYNKK STISAREIQT AVRLILPGEL AKHAVSEGTR 120
AVTKYSSSTQ A 132
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR009072--Histone-fold
IPR007125--Histone_H2A/H2B/H3
IPR000558--Histone_H2B
PROSITE

PS00357--HISTONE_H2B
Pfam

PF00125--Histone
Gene Ontology

GO:0000788--C:nuclear nucleosome
GO:0031298--C:replication fork protection complex
GO:0003677--F:DNA binding
GO:0006333--P:chromatin assembly or disassembly
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006334--P:nucleosome assembly
GO:0006301--P:postreplication repair