| Tag |
Content |
| dbPAF ID |
dbPAF-0003825 |
| Uniprot Accession |
P00830; ATPB_YEAST; D6VWU0;
|
| Genbank Protein ID |
NP_012655.3;
|
| Genbank Nucleotide ID |
NM_001181779.3;
|
| Protein Name |
ATP synthase subunit beta, mitochondrial |
| Protein Synonyms/Alias |
|
| Gene Name |
ATP2 |
| Gene Synonyms/Alias |
YJR121W;J2041; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.Functional Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MVLPRLYTAT SRAAFKAAKQ SAPLLSTSWK RCMASAAQST PITGKVTAVI GAIVDVHFEQ 60
SELPAILNAL EIKTPQGKLV LEVAQHLGEN TVRTIAMDGT EGLVRGEKVL DTGGPISVPV 120
GRETLGRIIN VIGEPIDERG PIKSKLRKPI HADPPSFAEQ STSAEILETG IKVVDLLAPY 180
ARGGKIGLFG GAGVGKTVFI QELINNIAKA HGGFSVFTGV GERTREGNDL YREMKETGVI 240
NLEGESKVAL VFGQMNEPPG ARARVALTGL TIAEYFRDEE GQDVLLFIDN IFRFTQAGSE 300
VSALLGRIPS AVGYQPTLAT DMGLLQERIT TTKKGSVTSV QAVYVPADDL TDPAPATTFA 360
HLDATTVLSR GISELGIYPA VDPLDSKSRL LDAAVVGQEH YDVASKVQET LQTYKSLQDI 420
IAILGMDELS EQDKLTVERA RKIQRFLSQP FAVAEVFTGI PGKLVRLKDT VASFKAVLEG 480
KYDNIPEHAF YMVGGIEDVV AKAEKLAAEA N
512Fasta Sequence
>P00830|ATP2|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MVLPRLYTATSRAAFKAAKQSAPLLSTSWKRCMASAAQSTPITGKVTAVIGAIVDVHFEQSELPAILNALEIKTPQGKLVLEVAQHLGENTVRTIAMDGTEGLVRGEKVLDTGGPISVPVGRETLGRIINVIGEPIDERGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETGVINLEGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRLLDAAVVGQEHYDVASKVQETLQTYKSLQDIIAILGMDELSEQDKLTVERARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIPEHAFYMVGGIEDVVAKAEKLAAEAN
|
| Keyword |
KW-0002--3D-structure
KW-0066--ATP synthesis
KW-0067--ATP-binding
KW-0139--CF(1)
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0375--Hydrogen ion transport
KW-0378--Hydrolase
KW-0406--Ion transport
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
|
| Interpro |
IPR003593--AAA+_ATPase
IPR020003--ATPase_a/bsu_AS
IPR005722--ATPase_F1-cplx_bsu
IPR000793--ATPase_F1/V1/A1-cplx_a/bsu_C
IPR000194--ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR004100--ATPase_F1_a/bsu_N
IPR024034--ATPase_F1_bsu/V1_C
IPR027417--P-loop_NTPase
|
| PROSITE |
PS00152--ATPASE_ALPHA_BETA
|
| Pfam |
PF00006--ATP-synt_ab
PF00306--ATP-synt_ab_C
PF02874--ATP-synt_ab_N
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005754--C:mitochondrial proton-transporting ATP synthase, catalytic core
GO:0005524--F:ATP binding
GO:0046933--F:proton-transporting ATP synthase activity, rotational mechanism
GO:0046961--F:proton-transporting ATPase activity, rotational mechanism
GO:0015991--P:ATP hydrolysis coupled proton transport
GO:0015986--P:ATP synthesis coupled proton transport
|
