dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003823
Uniprot Accession P00815; HIS2_YEAST; D6VQY5;
Genbank Protein ID NP_009900.2;
Genbank Nucleotide ID NM_001178675.1;
Protein Name Histidine biosynthesis trifunctional protein
Protein Synonyms/Alias
Gene Name HIS4
Gene Synonyms/Alias YCL030C;YCL183;YCL30C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
250HGLVGLESLLKQRLQcurated22369663
263LQDAPEESYTRRLFNPhosphoGRID 2.0;curated20489023; 22369663
265DAPEESYTRRLFNDSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663
272TRRLFNDSALLDAKIcurated22369663
416KFDGVKLSNPVLNAPcurated22369663
524RKSDGKVSPEVVYVAcurated22369663; 24961812
Sequence
(Fasta)		MVLPILPLID DLASWNSKKE YVSLVGQVLL DGSSLSNEEI LQFSKEEEVP LVALSLPSGK 60
FSDDEIIAFL NNGVSSLFIA SQDAKTAEHL VEQLNVPKER VVVEENGVFS NQFMVKQKFS 120
QDKIVSIKKL SKDMLTKEVL GEVRTDRPDG LYTTLVVDQY ERCLGLVYSS KKSIAKAIDL 180
GRGVYYSRSR NEIWIKGETS GNGQKLLQIS TDCDSDALKF IVEQENVGFC HLETMSCFGE 240
FKHGLVGLES LLKQRLQDAP EESYTRRLFN DSALLDAKIK EEAEELTEAK GKKELSWEAA 300
DLFYFALAKL VANDVSLKDV ENNLNMKHLK VTRRKGDAKP KFVGQPKAEE EKLTGPIHLD 360
VVKASDKVGV QKALSRPIQK TSEIMHLVNP IIENVRDKGN SALLEYTEKF DGVKLSNPVL 420
NAPFPEEYFE GLTEEMKEAL DLSIENVRKF HAAQLPTETL EVETQPGVLC SRFPRPIEKV 480
GLYIPGGTAI LPSTALMLGV PAQVAQCKEI VFASPPRKSD GKVSPEVVYV AEKVGASKIV 540
LAGGAQAVAA MAYGTETIPK VDKILGPGNQ FVTAAKMYVQ NDTQALCSID MPAGPSEVLV 600
IADEDADVDF VASDLLSQAE HGIDSQVILV GVNLSEKKIQ EIQDAVHNQA LQLPRVDIVR 660
KCIAHSTIVL CDGYEEALEM SNQYAPEHLI LQIANANDYV KLVDNAGSVF VGAYTPESCG 720
DYSSGTNHTL PTYGYARQYS GANTATFQKF ITAQNITPEG LENIGRAVMC VAKKEGLDGH 780
RNAVKIRMSK LGLIPKDFQ
Keyword

KW-0028--Amino-acid biosynthesis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0368--Histidine biosynthesis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0520--NAD
KW-0547--Nucleotide-binding
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR016161--Ald_DH/histidinol_DH
IPR016298--Histidine_synth_trifunct
IPR001692--Histidinol_DH_CS
IPR012131--Hstdl_DH
IPR008179--PRib-ATP_PPHydrolase
IPR021130--PRib-ATP_PPHydrolase-like
IPR002496--PRib_AMP_CycHydrolase_dom
PROSITE

PS00611--HISOL_DEHYDROGENASE
Pfam

PF00815--Histidinol_dh
PF01502--PRA-CH
PF01503--PRA-PH
Gene Ontology

GO:0005524--F:ATP binding
GO:0004399--F:histidinol dehydrogenase activity
GO:0051287--F:NAD binding
GO:0004635--F:phosphoribosyl-AMP cyclohydrolase activity
GO:0004636--F:phosphoribosyl-ATP diphosphatase activity
GO:0008270--F:zinc ion binding
GO:0000105--P:histidine biosynthetic process