Tag |
Content |
dbPAF ID |
dbPAF-0003794 |
Uniprot Accession |
P00546; CDK1_YEAST; D6VQF5; |
Genbank Protein ID |
NP_009718.3; |
Genbank Nucleotide ID |
NM_001178508.3; |
Protein Name |
Cyclin-dependent kinase 1 |
Protein Synonyms/Alias |
|
Gene Name |
CDC28 |
Gene Synonyms/Alias |
CDK1;HSL5;SRM5;YBR160W;YBR1211; |
Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
NCBI Taxa ID |
559292 |
Functional Description (View all) |
This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.Functional Description
This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.
|
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence (Fasta) | MSGELANYKR LEKVGEGTYG VVYKALDLRP GQGQRVVALK KIRLESEDEG VPSTAIREIS 60 LLKELKDDNI VRLYDIVHSD AHKLYLVFEF LDLDLKRYME GIPKDQPLGA DIVKKFMMQL 120 CKGIAYCHSH RILHRDLKPQ NLLINKDGNL KLGDFGLARA FGVPLRAYTH EIVTLWYRAP 180 EVLLGGKQYS TGVDTWSIGC IFAEMCNRKP IFSGDSEIDQ IFKIFRVLGT PNEAIWPDIV 240 YLPDFKPSFP QWRRKDLSQV VPSLDPRGID LLDKLLAYDP INRISARRAA IHPYFQES
299Fasta Sequence
>P00546|CDC28|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES
|
Keyword |
KW-0007--Acetylation KW-0067--ATP-binding KW-0131--Cell cycle KW-0132--Cell division KW-0181--Complete proteome KW-0418--Kinase KW-0498--Mitosis KW-0547--Nucleotide-binding KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0723--Serine/threonine-protein kinase KW-0808--Transferase
|
Interpro |
IPR011009--Kinase-like_dom IPR000719--Prot_kinase_dom IPR017441--Protein_kinase_ATP_BS IPR002290--Ser/Thr_dual-sp_kinase IPR008271--Ser/Thr_kinase_AS
|
PROSITE |
PS00107--PROTEIN_KINASE_ATP PS50011--PROTEIN_KINASE_DOM PS00108--PROTEIN_KINASE_ST
|
Pfam |
PF00069--Pkinase
|
Gene Ontology |
GO:0005935--C:cellular bud neck GO:0000307--C:cyclin-dependent protein kinase holoenzyme complex GO:0005737--C:cytoplasm GO:0005783--C:endoplasmic reticulum GO:0005634--C:nucleus GO:0005524--F:ATP binding GO:0004693--F:cyclin-dependent protein serine/threonine kinase activity GO:0042393--F:histone binding GO:0004674--F:protein serine/threonine kinase activity GO:0000993--F:RNA polymerase II core binding GO:0006370--P:7-methylguanosine mRNA capping GO:0051301--P:cell division GO:0000706--P:meiotic DNA double-strand break processing GO:1990758--P:mitotic sister chromatid biorientation GO:2001033--P:negative regulation of double-strand break repair via nonhomologous end joining GO:0051447--P:negative regulation of meiotic cell cycle GO:0045930--P:negative regulation of mitotic cell cycle GO:0045875--P:negative regulation of sister chromatid cohesion GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitosis GO:0045892--P:negative regulation of transcription, DNA-templated GO:0018105--P:peptidyl-serine phosphorylation GO:0070816--P:phosphorylation of RNA polymerase II C-terminal domain GO:0051446--P:positive regulation of meiotic cell cycle GO:0045931--P:positive regulation of mitotic cell cycle GO:0010571--P:positive regulation of nuclear cell cycle DNA replication GO:0010696--P:positive regulation of spindle pole body separation GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:0010898--P:positive regulation of triglyceride catabolic process GO:1990139--P:protein localization to nuclear periphery GO:0034504--P:protein localization to nucleus GO:1902002--P:protein phosphorylation involved in cellular protein catabolic process GO:1990802--P:protein phosphorylation involved in DNA double-strand break processing GO:1990804--P:protein phosphorylation involved in double-strand break repair via nonhomologous end joining GO:1990801--P:protein phosphorylation involved in mitotic spindle assembly GO:1990803--P:protein phosphorylation involved in protein localization to spindle microtubule GO:0010568--P:regulation of budding cell apical bud growth GO:0010569--P:regulation of double-strand break repair via homologous recombination GO:0010570--P:regulation of filamentous growth GO:0060303--P:regulation of nucleosome density GO:0090169--P:regulation of spindle assembly GO:0032210--P:regulation of telomere maintenance via telomerase GO:0007130--P:synaptonemal complex assembly GO:0016192--P:vesicle-mediated transport
|