dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0003794
Uniprot Accession P00546; CDK1_YEAST; D6VQF5;
Genbank Protein ID NP_009718.3;
Genbank Nucleotide ID NM_001178508.3;
Protein Name Cyclin-dependent kinase 1
Protein Synonyms/Alias
Gene Name CDC28
Gene Synonyms/Alias CDK1;HSL5;SRM5;YBR160W;YBR1211;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
18LEKVGEGTYGVVYKAcurated22817900; 19547744
19EKVGEGTYGVVYKALdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 18407956; 16381945; 23193290; 21177495; 21126336;
46LKKIRLESEDEGVPSPhosphoGRID 2.011827161; 10998356
168FGVPLRAYTHEIVTLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17330950; 16381945; 23193290; 20489023; 19060867; 19366988;
169GVPLRAYTHEIVTLWdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 15665377; 16381945; 23193290; 21126336; 19779198;
190LLGGKQYSTGVDTWSPhosphoGRID 2.020489023
191LGGKQYSTGVDTWSIPhosphoGRID 2.020489023
Sequence
(Fasta)
MSGELANYKR LEKVGEGTYG VVYKALDLRP GQGQRVVALK KIRLESEDEG VPSTAIREIS 60
LLKELKDDNI VRLYDIVHSD AHKLYLVFEF LDLDLKRYME GIPKDQPLGA DIVKKFMMQL 120
CKGIAYCHSH RILHRDLKPQ NLLINKDGNL KLGDFGLARA FGVPLRAYTH EIVTLWYRAP 180
EVLLGGKQYS TGVDTWSIGC IFAEMCNRKP IFSGDSEIDQ IFKIFRVLGT PNEAIWPDIV 240
YLPDFKPSFP QWRRKDLSQV VPSLDPRGID LLDKLLAYDP INRISARRAA IHPYFQES 299
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0418--Kinase
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

Gene Ontology

GO:0005935--C:cellular bud neck
GO:0000307--C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004693--F:cyclin-dependent protein serine/threonine kinase activity
GO:0042393--F:histone binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0000993--F:RNA polymerase II core binding
GO:0006370--P:7-methylguanosine mRNA capping
GO:0051301--P:cell division
GO:0000706--P:meiotic DNA double-strand break processing
GO:1990758--P:mitotic sister chromatid biorientation
GO:2001033--P:negative regulation of double-strand break repair via nonhomologous end joining
GO:0051447--P:negative regulation of meiotic cell cycle
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0045875--P:negative regulation of sister chromatid cohesion
GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018105--P:peptidyl-serine phosphorylation
GO:0070816--P:phosphorylation of RNA polymerase II C-terminal domain
GO:0051446--P:positive regulation of meiotic cell cycle
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0010571--P:positive regulation of nuclear cell cycle DNA replication
GO:0010696--P:positive regulation of spindle pole body separation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010898--P:positive regulation of triglyceride catabolic process
GO:1990139--P:protein localization to nuclear periphery
GO:0034504--P:protein localization to nucleus
GO:1902002--P:protein phosphorylation involved in cellular protein catabolic process
GO:1990802--P:protein phosphorylation involved in DNA double-strand break processing
GO:1990804--P:protein phosphorylation involved in double-strand break repair via nonhomologous end joining
GO:1990801--P:protein phosphorylation involved in mitotic spindle assembly
GO:1990803--P:protein phosphorylation involved in protein localization to spindle microtubule
GO:0010568--P:regulation of budding cell apical bud growth
GO:0010569--P:regulation of double-strand break repair via homologous recombination
GO:0010570--P:regulation of filamentous growth
GO:0060303--P:regulation of nucleosome density
GO:0090169--P:regulation of spindle assembly
GO:0032210--P:regulation of telomere maintenance via telomerase
GO:0007130--P:synaptonemal complex assembly
GO:0016192--P:vesicle-mediated transport