dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003791
Uniprot Accession P00533; EGFR_HUMAN; O00688; O00732; P06268; Q14225; Q68GS5; Q92795; Q9BZS2; Q9GZX1; Q9H2C9; Q9H3C9; Q9UMD7; Q9UMD8; Q9UMG5;
Genbank Protein ID NP_005219.2; NP_958439.1; NP_958440.1; NP_958441.1;
Genbank Nucleotide ID NM_005228.3; NM_201282.1; NM_201283.1; NM_201284.1;
Protein Name Epidermal growth factor receptor
Protein Synonyms/Alias Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;
Gene Name EGFR
Gene Synonyms/Alias ERBB;ERBB1;HER1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
Phosphorylation Sites
 dbPAF PTMs: 74 (View all)
PositionPeptidesSourceReferences ( PMIDs )
77VQRNYDLSFLKTIQEPhosphoSitePlus22135298
112QIIRGNMYYENSYALPhosphoSitePlus22135298
113IIRGNMYYENSYALAPhosphoSitePlus22135298
117NMYYENSYALAVLSNPhosphoSitePlus22135298
151LHGAVRFSNNPALCNdbPTM 3.0;PhosphoSitePlus21080693; 16381945; 23193290; 22135298
229RCRGKSPSDCCHNQCdbPTM 3.0;PhosphoSitePlus;UniProt21487020; 16381945; 23193290; 22135298
290GKYSFGATCVKKCPRdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
511QVCHALCSPEGCWGPdbPTM 3.0;PhosphoSitePlus21080693; 16381945; 23193290; 22135298
585NCIQCAHYIDGPHCVdbPTM 3.0;PhosphoSitePlus21080693; 16381945; 23193290; 22135298
645TNGPKIPSIATGMVGPhosphoSitePlus22135298
648PKIPSIATGMVGALLPhosphoSitePlus22135298
678RHIVRKRTLRRLLQEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated10523301; 16381945; 23193290; 3379075; 15302935; 1860884; 60
693RELVEPLTPSGEAPNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated3138233; 10523301; 15302935; 16083266; 17081983; 17192257; 1
695LVEPLTPSGEAPNQAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated3138233; 18669648; 18691976; 16381945; 23193290; 15302935; 1
720KKIKVLGSGAFGTVYdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
725LGSGAFGTVYKGLWIdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 20068231; 18988627; 21081558;
727SGAFGTVYKGLWIPEdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated15657067; 18083107; 18180459; 18776048; 20736484; 21080693;
752KELREATSPKANKEIdbPTM 3.0;PhosphoSitePlus;curated17855441; 16381945; 23193290; 22135298; 22817900
764KEILDEAYVMASVDNdbPTM 3.0;PhosphoSitePlus;curated15657067; 21080693; 9777370; 16381945; 23193290; 22135298; 2
768DEAYVMASVDNPHVCdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated15302935; 10347170; 16381945; 23193290; 16357520; 17653080;
Sequence
(Fasta)		MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 60
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 120
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF 180
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 240
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK 360
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 420
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL 480
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN 540
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 600
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV 660
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 720
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 780
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 840
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 900
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 960
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ 1020
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 1080
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN 1140
TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV 1200
APQSSEFIGA 1211
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0472--Membrane
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0043--Tumor suppressor
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR006211--Furin-like_Cys-rich_dom
IPR006212--Furin_repeat
IPR009030--Growth_fac_rcpt_N_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR000494--Rcpt_L-dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR016245--Tyr_kinase_EGF/ERB/XmrK_rcpt
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
Pfam

PF00757--Furin-like
PF07714--Pkinase_Tyr
PF01030--Recep_L_domain
Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0031901--C:early endosome membrane
GO:0030139--C:endocytic vesicle
GO:0005789--C:endoplasmic reticulum membrane
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0045121--C:membrane raft
GO:0097489--C:multivesicular body, internal vesicle lumen
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043235--C:receptor complex
GO:0070435--C:Shc-EGFR complex
GO:0051015--F:actin filament binding
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003690--F:double-stranded DNA binding
GO:0019899--F:enzyme binding
GO:0005006--F:epidermal growth factor-activated receptor activity
GO:0042802--F:identical protein binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0046982--F:protein heterodimerization activity
GO:0019903--F:protein phosphatase binding
GO:0004713--F:protein tyrosine kinase activity
GO:0004716--F:receptor signaling protein tyrosine kinase activity
GO:0004714--F:transmembrane receptor protein tyrosine kinase activity
GO:0004888--F:transmembrane signaling receptor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000186--P:activation of MAPKK activity
GO:0043006--P:activation of phospholipase A2 activity by calcium-mediated signaling
GO:0007202--P:activation of phospholipase C activity
GO:0007411--P:axon guidance
GO:0008283--P:cell proliferation
GO:0007166--P:cell surface receptor signaling pathway
GO:0071230--P:cellular response to amino acid stimulus
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0071392--P:cellular response to estradiol stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0048546--P:digestive tract morphogenesis
GO:0001892--P:embryonic placenta development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0001942--P:hair follicle development
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0007611--P:learning or memory
GO:0000165--P:MAPK cascade
GO:0060571--P:morphogenesis of an epithelial fold
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0042177--P:negative regulation of protein catabolic process
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0001503--P:ossification
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0031659--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0045739--P:positive regulation of DNA repair
GO:0045740--P:positive regulation of DNA replication
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0043406--P:positive regulation of MAP kinase activity
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0042327--P:positive regulation of phosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0001934--P:positive regulation of protein phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777--P:protein autophosphorylation
GO:0051205--P:protein insertion into membrane
GO:0007265--P:Ras protein signal transduction
GO:0050999--P:regulation of nitric-oxide synthase activity
GO:0050730--P:regulation of peptidyl-tyrosine phosphorylation
GO:0006950--P:response to stress
GO:0070141--P:response to UV-A
GO:0007435--P:salivary gland morphogenesis
GO:0007165--P:signal transduction
GO:0016337--P:single organismal cell-cell adhesion
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway