dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003789
Uniprot Accession P00522; ABL_DROME; Q95TV1; Q9VV86;
Genbank Protein ID NP_001287085.1; NP_524843.2;
Genbank Nucleotide ID NM_001300156.1; NM_080104.3;
Protein Name Tyrosine-protein kinase Abl
Protein Synonyms/Alias D-ash;Protein abelson;
Gene Name Abl
Gene Synonyms/Alias ABL-1;Dash;CG4032;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
521ARLMRDDTYTAHAGAPHOSIDA;curated21081558; 22817900
522RLMRDDTYTAHAGAKdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curatedN.N.; 16381945; 23193290; 18281928; 21081558; 19060867; 1936
523LMRDDTYTAHAGAKFPHOSIDA;curated21081558; 22817900
758PAPPKRTSLLSSSRDPHOSIDA;curated21081558; 22817900
795GLARDINSLTQRYDSPHOSIDA;curated21081558; 22817900
928VKQVVNRYGTLPKGAdbPTM 3.0;SysPTM 2.018281928; 16381945; 23193290; 19366988
930QVVNRYGTLPKGARIcurated22817900
990PPQQMIRSNSSGGVTPhosphoPep 2.019060867
992QQMIRSNSSGGVTMQPhosphoPep 2.019060867
1025GTMMTFSSFRAGGSSPhosphoPep 2.019060867
1283ANNANCNTTGTLNRKPhosphoPep 2.019060867
1284NNANCNTTGTLNRKEPhosphoPep 2.019060867
1286ANCNTTGTLNRKEDGPhosphoPep 2.019060867
1332GDLGKRRSTGSINSLPHOSIDA;curated21081558; 22817900
1335GKRRSTGSINSLKKLPHOSIDA21081558
1497KPTKLTIYATPIAKLdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17372656; 16381945; 23193290; 18281928; 21081558; 19060867;
Sequence
(Fasta)		MGAQQGKDRG AHSGGGGSGA PVSCIGLSSS PVASVSPHCI SSSSGVSSAP LGGGSTLRGS 60
RIKSSSSGVA SGSGSGGGGG GSGSGLSQRS GGHKDARCNP TVGLNIFTEH NEALLQSRPL 120
PHIPAGSTAA SLLADAAELQ QHQQDSGGLG LQGSSLGGGH SSTTSVFESA HRWTSKENLL 180
APGPEEDDPQ LFVALYDFQA GGENQLSLKK GEQVRILSYN KSGEWCEAHS DSGNVGWVPS 240
NYVTPLNSLE KHSWYHGPIS RNAAEYLLSS GINGSFLVRE SESSPGQRSI SLRYEGRVYH 300
YRISEDPDGK VFVTQEAKFN TLAELVHHHS VPHEGHGLIT PLLYPAPKQN KPTVFPLSPE 360
PDEWEICRTD IMMKHKLGGG QYGEVYEAVW KRYGNTVAVK TLKEDTMALK DFLEEAAIMK 420
EMKHPNLVQL IGVCTREPPF YIITEFMSHG NLLDFLRSAG RETLDAVALL YMATQIASGM 480
SYLESRNYIH RDLAARNCLV GDNKLVKVAD FGLARLMRDD TYTAHAGAKF PIKWTAPEGL 540
AYNKFSTKSD VWAFGVLLWE IATYGMSPYP AIDLTDVYHK LDKGYRMERP PGCPPEVYDL 600
MRQCWQWDAT DRPTFKSIHH ALEHMFQESS ITEAVEKQLN ANATSASSSA PSTSGVATGG 660
GATTTTAASG CASSSSATAS LSLTPQMVKK GLPGGQALTP NAHHNDPHQQ QASTPMSETG 720
STSTKLSTFS SQGKGNVQMR RTTNKQGKQA PAPPKRTSLL SSSRDSTYRE EDPANARCNF 780
IDDLSTNGLA RDINSLTQRY DSETDPAADP DTDATGDSLE QSLSQVIAAP VTNKMQHSLH 840
SGGGGGGIGP RSSQQHSSFK RPTGTPVMGN RGLETRQSKR SQLHSQAPGP GPPSTQPHHG 900
NNGVVTSAHP ITVGALDVMN VKQVVNRYGT LPKGARIGAY LDSLEDSSEA APALPATAPS 960
LPPANGHATP PAARLNPKAS PIPPQQMIRS NSSGGVTMQN NAAASLNKLQ RHRTTTEGTM 1020
MTFSSFRAGG SSSSPKRSAS GVASGVQPAL ANLEFPPPPL DLPPPPEEFE GGPPPPPPAP 1080
ESAVQAIQQH LHAQLPNNGN ISNGNGTNNN DSSHNDVSNI APSVEEASSR FGVSLRKREP 1140
STDSCSSLGS PPEDLKEKLI TEIKAAGKDT APASHLANGS GIAVVDPVSL LVTELAESMN 1200
LPKPPPQQQQ KLTNGNSTGS GFKAQLKKVE PKKMSAPMPK AEPANTIIDF KAHLRRVDKE 1260
KEPATPAPAP ATVAVANNAN CNTTGTLNRK EDGSKKFSQA MQKTEIKIDV TNSNVEADAG 1320
AAGEGDLGKR RSTGSINSLK KLWEQQPPAP DYATSTILQQ QPSVVNGGGT PNAQLSPKYG 1380
MKSGAINTVG TLPAKLGNKQ PPAAPPPPPP NCTTSNSSTT SISTSSRDCT SRQQASSTIK 1440
TSHSTQLFTD DEEQSHTEGL GSGGQGSADM TQSLYEQKPQ IQQKPAVPHK PTKLTIYATP 1500
IAKLTEPASS ASSTQISRES ILELVGLLEG SLKHPVNAIA GSQWLQLSDK LNILHNSCVI 1560
FAENGAMPPH SKFQFRELVT RVEAQSQHLR SAGSKNVQDN ERLVAEVGQS LRQISNALNR 1620
1621
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
Gene Ontology

GO:0005912--C:adherens junction
GO:0045179--C:apical cortex
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0005927--C:muscle tendon junction
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0007411--P:axon guidance
GO:0016199--P:axon midline choice point recognition
GO:0007409--P:axonogenesis
GO:0021785--P:branchiomotor neuron axon guidance
GO:0030154--P:cell differentiation
GO:0007417--P:central nervous system development
GO:0048749--P:compound eye development
GO:0007303--P:cytoplasmic transport, nurse cell to oocyte
GO:0048813--P:dendrite morphogenesis
GO:0007391--P:dorsal closure
GO:0003382--P:epithelial cell morphogenesis
GO:0045087--P:innate immune response
GO:0007611--P:learning or memory
GO:0002009--P:morphogenesis of an epithelium
GO:0008045--P:motor neuron axon guidance
GO:0010977--P:negative regulation of neuron projection development
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0001764--P:neuron migration
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0072499--P:photoreceptor cell axon guidance
GO:0003402--P:planar cell polarity pathway involved in axis elongation
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0046827--P:positive regulation of protein export from nucleus
GO:0006468--P:protein phosphorylation
GO:0008064--P:regulation of actin polymerization or depolymerization
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0032880--P:regulation of protein localization
GO:0031647--P:regulation of protein stability
GO:0007268--P:synaptic transmission
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007419--P:ventral cord development
GO:0007370--P:ventral furrow formation