dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003754
Uniprot Accession P00331; ADH2_YEAST; D6W0D0;
Genbank Protein ID NP_014032.1;
Genbank Nucleotide ID NM_001182812.1;
Protein Name Alcohol dehydrogenase 2
Protein Synonyms/Alias Alcohol dehydrogenase II;YADH-2;
Gene Name ADH2
Gene Synonyms/Alias ADR2;YMR303C;YM9952.05C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
212PGKEELFTSLGGEVFcurated22817900; 19547744
213GKEELFTSLGGEVFIcurated22817900; 19547744
223GEVFIDFTKEKDIVScurated19547744
288VFNHVVKSISIVGSYdbPTM 3.0;PhosphoGRID 2.0;curated18407956; 16381945; 23193290; 17330950; 19779198; 22817900
290NHVVKSISIVGSYVGdbPTM 3.0;PhosphoGRID 2.015665377; 17287358; 18407956; 16381945; 23193290; 19779198
294KSISIVGSYVGNRADdbPTM 3.017287358; 16381945; 23193290
302YVGNRADTREALDFFdbPTM 3.017287358; 16381945; 23193290
316FARGLVKSPIKVVGLdbPTM 3.017330950; 18407956; 16381945; 23193290
Sequence
(Fasta)		MSIPETQKAI IFYESNGKLE HKDIPVPKPK PNELLINVKY SGVCHTDLHA WHGDWPLPTK 60
LPLVGGHEGA GVVVGMGENV KGWKIGDYAG IKWLNGSCMA CEYCELGNES NCPHADLSGY 120
THDGSFQEYA TADAVQAAHI PQGTDLAEVA PILCAGITVY KALKSANLRA GHWAAISGAA 180
GGLGSLAVQY AKAMGYRVLG IDGGPGKEEL FTSLGGEVFI DFTKEKDIVS AVVKATNGGA 240
HGIINVSVSE AAIEASTRYC RANGTVVLVG LPAGAKCSSD VFNHVVKSIS IVGSYVGNRA 300
DTREALDFFA RGLVKSPIKV VGLSSLPEIY EKMEKGQIAG RYVVDTSK 349
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR013149--ADH_C
IPR013154--ADH_N
IPR002085--ADH_SF_Zn-type
IPR002328--ADH_Zn_CS
IPR011032--GroES-like
IPR016040--NAD(P)-bd_dom
PROSITE

PS00059--ADH_ZINC
Pfam

PF08240--ADH_N
PF00107--ADH_zinc_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004022--F:alcohol dehydrogenase (NAD) activity
GO:0008270--F:zinc ion binding
GO:0000947--P:amino acid catabolic process to alcohol via Ehrlich pathway
GO:0006067--P:ethanol metabolic process
GO:0006116--P:NADH oxidation