dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003753
Uniprot Accession P00330; ADH1_YEAST; D6W1Y3;
Genbank Protein ID NP_014555.1;
Genbank Nucleotide ID NM_001183340.1;
Protein Name Alcohol dehydrogenase 1
Protein Synonyms/Alias Alcohol dehydrogenase I;YADH-1;
Gene Name ADH1
Gene Synonyms/Alias ADC1;YOL086C;O0947;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 This isozyme preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also also shows activity toward secondary alcohols.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
2------MSIPETQKGPhosphoGRID 2.0;curated19823750; 19795423; 26040289; 24961812
6--MSIPETQKGVIFYcurated19547744
15KGVIFYESHGKLEYKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 24961812; 25315811;
21ESHGKLEYKDIPVPKPhosphoGRID 2.0;curated19779198; 22817900
213GKEELFRSIGGEVFIdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988; 22817900
223GEVFIDFTKEKDIVGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988; 22817900
249GVINVSVSEAAIEASSysPTM 2.018407956; 19366988
266YVRANGTTVLVGMPAPhosphoPep 2.019060867
279PAGAKCCSDVFNQVVPhosphoGRID 2.0;UniProt;curated19779198; 22817900
288VFNQVVKSISIVGSYPhosphoPep 2.0;SysPTM 2.0;curated19060867; 18407956; 19366988; 17330950; 26040289; 22817900;
290NQVVKSISIVGSYVGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated15665377; 16381945; 23193290; 17287358; 19060867; 19366988;
294KSISIVGSYVGNRADPhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17287358; 19060867; 19366988; 22817900
295SISIVGSYVGNRADTPhosphoGRID 2.0;PhosphoPep 2.019779198; 19060867
302YVGNRADTREALDFFPhosphoGRID 2.0;SysPTM 2.0;curated17287358; 19366988; 18407956; 22817900
316FARGLVKSPIKVVGLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 17330950; 17563356; 18407956; 16381945; 23193290;
324PIKVVGLSTLPEIYEPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 26040289; 25521595
325IKVVGLSTLPEIYEKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 19366988; 25521595;
330LSTLPEIYEKMEKGQPhosphoPep 2.019060867
Sequence
(Fasta)		MSIPETQKGV IFYESHGKLE YKDIPVPKPK ANELLINVKY SGVCHTDLHA WHGDWPLPVK 60
LPLVGGHEGA GVVVGMGENV KGWKIGDYAG IKWLNGSCMA CEYCELGNES NCPHADLSGY 120
THDGSFQQYA TADAVQAAHI PQGTDLAQVA PILCAGITVY KALKSANLMA GHWVAISGAA 180
GGLGSLAVQY AKAMGYRVLG IDGGEGKEEL FRSIGGEVFI DFTKEKDIVG AVLKATDGGA 240
HGVINVSVSE AAIEASTRYV RANGTTVLVG MPAGAKCCSD VFNQVVKSIS IVGSYVGNRA 300
DTREALDFFA RGLVKSPIKV VGLSTLPEIY EKMEKGQIVG RYVVDTSK 349
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR013149--ADH_C
IPR013154--ADH_N
IPR002085--ADH_SF_Zn-type
IPR002328--ADH_Zn_CS
IPR011032--GroES-like
IPR016040--NAD(P)-bd_dom
PROSITE

PS00059--ADH_ZINC
Pfam

PF08240--ADH_N
PF00107--ADH_zinc_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004022--F:alcohol dehydrogenase (NAD) activity
GO:0019170--F:methylglyoxal reductase (NADH-dependent) activity
GO:0008270--F:zinc ion binding
GO:0000947--P:amino acid catabolic process to alcohol via Ehrlich pathway
GO:0043458--P:ethanol biosynthetic process involved in glucose fermentation to ethanol
GO:0006116--P:NADH oxidation