dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003734
Uniprot Accession O97159; CHDM_DROME; Q8MZ43; Q9VW50;
Genbank Protein ID NP_001163476.1; NP_649154.2;
Genbank Nucleotide ID NM_001170005.2; NM_140897.4;
Protein Name Chromodomain-helicase-DNA-binding protein Mi-2 homolog
Protein Synonyms/Alias ATP-dependent helicase Mi-2;dMi-2;
Gene Name Mi-2
Gene Synonyms/Alias CG8103;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Vital role in development. Protein binds to a portion of Hunchback (HB) protein that is critical for repression of bithorax complex (BXC) genes. May also function in polycomb group (PcG) repression of Hox genes.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
79KKRKKNESEEDSDFVdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
83KNESEEDSDFVQHDEdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
201QEGGAAGSGGSAGQAdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19366988
204GAAGSGGSAGQARSVdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19366988
210GSAGQARSVTGDEPEdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
221DEPEEPRSSRSSRNEdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19366988
284LGKRKRDSSDEEQDAdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19366988
285GKRKRDSSDEEQDASdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19060867; 19366988
292SDEEQDASGASERDSdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19366988
295EQDASGASERDSDLEdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt18327897; 16381945; 23193290; 19366988
299SGASERDSDLEFERMdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
310FERMLQKSDDSADEKdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
313MLQKSDDSADEKEAPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
569EPPKFEESLDEADTRdbPTM 3.0;SysPTM 2.018327897; 16381945; 23193290; 19366988
701EDRPVKHYTPPPEKPdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
702DRPVKHYTPPPEKPTdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
709TPPPEKPTTDLKKKYPHOSIDA;curated21081558; 22817900
1563PATSAAPSPAPASEKPhosphoPep 2.0;curated19060867; 22817900
1691DGELEKPSASSPKDQdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 22817900
1694LEKPSASSPKDQKAVdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
Sequence
(Fasta)		MASEEENDDN FQEEEEAQED NAPAAELSND SDAPLKPNND EDDDYDPEDS RRKKKGKKRK 60
TRKGEEKGRK KKKRKKNESE EDSDFVQHDE EVEYPSTSKR GRKRKEEKQA AKEKESASSG 120
MPSVEDVCSA FSVCNVEIEY SEEELQSLTT YKAFMHHVRP ILQKENPKIA APKLVMLVAA 180
KWREFCESNP HIQQEGGAAG SGGSAGQARS VTGDEPEEPR SSRSSRNEKP DDIYEEAVEE 240
EEEEEEEEKK PRRKRSGRGK KGRRPSGKVP TLKIKLLGKR KRDSSDEEQD ASGASERDSD 300
LEFERMLQKS DDSADEKEAP VSSKADNSAP AAQDDGSGAP VVRKKAKTKI GNKFKKKNKL 360
KKTKNFPEGE DGEHEHQDYC EVCQQGGEII LCDTCPRAYH LVCLEPELDE PPEGKWSCPH 420
CEADGGAAEE EDDDEHQEFC RVCKDGGELL CCDSCPSAYH TFCLNPPLDT IPDGDWRCPR 480
CSCPPLTGKA EKIITWRWAQ RSNDDGPSTS KGSKNSNSRV REYFIKWHNM SYWHCEWVPE 540
VQLDVHHPLM IRSFQRKYDM EEPPKFEESL DEADTRYKRI QRHKDKVGMK ANDDAEVLEE 600
RFYKNGVKPE WLIVQRVINH RTARDGSTMY LVKWRELPYD KSTWEEEGDD IQGLRQAIDY 660
YQDLRAVCTS ETTQSRSKKS KKGRKSKLKV EDDEDRPVKH YTPPPEKPTT DLKKKYEDQP 720
AFLEGTGMQL HPYQIEGINW LRYSWGQGID TILADEMGLG KTIQTVTFLY SLYKEGHCRG 780
PFLVAVPLST LVNWEREFEL WAPDFYCITY IGDKDSRAVI RENELSFEEG AIRGSKVSRL 840
RTTQYKFNVL LTSYELISMD AACLGSIDWA VLVVDEAHRL KSNQSKFFRI LNSYTIAYKL 900
LLTGTPLQNN LEELFHLLNF LSRDKFNDLQ AFQGEFADVS KEEQVKRLHE MLGPHMLRRL 960
KTDVLKNMPS KSEFIVRVEL SAMQKKFYKF ILTKNYEALN SKSGGGSCSL INIMMDLKKC 1020
CNHPYLFPSA AEEATTAAGG LYEINSLTKA AGKLVLLSKM LKQLKAQNHR VLIFSQMTKM 1080
LDILEDFLEG EQYKYERIDG GITGTLRQEA IDRFNAPGAQ QFVFLLSTRA GGLGINLATA 1140
DTVIIYDSDW NPHNDIQAFS RAHRIGQANK VMIYRFVTRN SVEERVTQVA KRKMMLTHLV 1200
VRPGMGGKGA NFTKQELDDI LRFGTEDLFK EDDKEEAIHY DDKAVAELLD RTNRGIEEKE 1260
SWANEYLSSF KVASYATKEE EEEEETEIIK QDAENSDPAY WVKLLRHHYE QHQEDVGRSL 1320
GKGKRVRKQV NYTDGGVVAA DTTRDDSNWQ DNGSEYNSEY SAGSDEDGGD DDFDDQNGAE 1380
RKAKRRLERR DDRPLPPLLA RVGGNIEVLG FNARQRKSFL NAIMRYGMPP QDAFNSQWLV 1440
RDLRGKSERN FKAYVSLFMR HLCEPGADNA ETFADGVPRE GLSRQHVLTR IGVMSLIRKK 1500
VQEFEHINGY YSMPELILKP CEPVRSALKQ DVAALEAPPT GGNVDKSATT SNSVTPATSA 1560
APSPAPASEK GEDKDKDSEK EKDKTSAEKS EVKQEQEAEE DKKPGDVKQE NPVEEAAGDT 1620
KPSDAEVKTE VAKTEPKEET KDPEVKEEPK TEEKEKEKVD DKKPIPPTTV IDDDDDDVMI 1680
VKEDGELEKP SASSPKDQKA VAAATSAATG ATGKGAEDSL EVLKRKFMFN IADGGFTELH 1740
TLWLNEEKAA VPGREYEIWH RRHDYWLLAG IVTHGYGRWQ DIQNDIRFAI INEPFKMDVG 1800
KGNFLEIKNK FLARRFKLLE QALVIEEQLR RAAYLNLAQD PSHPAMSLNA RFAEVECLAE 1860
SHQHLSKESL AGNKPANAVL HKVLNQLEEL LSDMKSDVSR LPATLARIPP VAQRLQMSER 1920
SILSRLAATA GNASNAAQLM AQFPAGFQGT TLPAFTSGPA GNFANFRPQF SVPGQLSNNS 1980
GV 1983
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR012957--CHD_C2
IPR012958--CHD_N
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR009462--DUF1086
IPR009463--DUF1087
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50013--CHROMO_2
PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF08074--CHDCT2
PF08073--CHDNT
PF00385--Chromo
PF06461--DUF1086
PF06465--DUF1087
PF00271--Helicase_C
PF00628--PHD
PF00176--SNF2_N
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0005700--C:polytene chromosome
GO:0035327--C:transcriptionally active chromatin
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0016887--F:ATPase activity
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0031491--F:nucleosome binding
GO:0070615--F:nucleosome-dependent ATPase activity
GO:0008270--F:zinc ion binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0051312--P:chromosome decondensation
GO:0051276--P:chromosome organization
GO:0048813--P:dendrite morphogenesis
GO:0032508--P:DNA duplex unwinding
GO:0007517--P:muscle organ development
GO:0071923--P:negative regulation of cohesin localization to chromatin
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042766--P:nucleosome mobilization
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated