dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0003727
Uniprot Accession O96838; FYV1_DROME; A4UZM3; Q8SZX0; Q95SX9; Q9V886;
Genbank Protein ID NP_611269.1; NP_995880.1;
Genbank Nucleotide ID NM_137425.4; NM_206158.3;
Protein Name Putative 1-phosphatidylinositol 3-phosphate 5-kinase
Protein Synonyms/Alias
Gene Name fab1
Gene Synonyms/Alias CG6355;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome-related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing.
Phosphorylation Sites
dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
17SSHQHLHSPSKLTEFPHOSIDA21081558
19HQHLHSPSKLTEFARPHOSIDA21081558
296APLPRKTSVGYQEERPhosphoPep 2.019060867
755PIILERKSEDKITTIdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;UniProt18327897; 16381945; 23193290; 19060867
760RKSEDKITTIVSENVdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
861TGLERPDSMGDGEAGPHOSIDA21081558
1407NSNAAHSSPQLKRKIPhosphoPep 2.019060867
1421IPLAESVSDAEDSPSPhosphoPep 2.019060867
1530ISQSRTGSEMELVRKdbPTM 3.0;Phospho.ELM 9.0;UniProt;curated18327897; 16381945; 23193290; 22817900
1539MELVRKPSDVGAPRTPhosphoPep 2.019060867
Sequence
(Fasta)
MTSNNQNNSS SHQHLHSPSK LTEFARNFED KPESLFGRVV NKIQNVYNQS YNTVNDISSG 60
SSSSSSTQPV QVVGKSQFFS DSQTSTAEIA DVETSSQSSV RPQPPTTLSI RTNSETRGTS 120
TSSNTAAEDS ETSDRVETLP LPTSEANQGR TVSNVLKHIS NIVATKNNND LRNYKDTELQ 180
RFWMPDSKAK ECYDCSQKFS TFRRKHHCRL CGQIFCSKCC NQVVPGMIIR CDGDLKVCNY 240
CSKIVLTFLK SSSSEMGQDM QELQQHLSNK LEVQDSGSSL AKHPQMQRAP LPRKTSVGYQ 300
EERFSSHPTY TTLSIDDRKN ILQQSNSLIT LHEEMQRDLP AQNCGQRLIE FLNSNNKSAN 360
EVQAVAILNA MLAAGFLEPI VPDPEQMDFD SSLHYKFSKS SSSDTSRTMS PQFEANPHAE 420
PQPPKSMDQS AEEKEKELEN ELENDRCYTT ATSKLLASYC EHEEQLLAQM LRAHNLDQEW 480
DKVLQMLCST AANHFKPEHC SNDLMDIRNY VNFKKVPGGR RKDSKIVHGV AFSKNVAHKD 540
MATHVPFPRI LLLQCPIVYE RIEGKFVTIE TVLLQEKEYL RNVCARIMSF KPNVVLVHKN 600
VAGIAQDLLR SYEVTLVLDV KLSVMERLSR TLQCDIVSSI ESNITMPKLG YCNDFYIRNY 660
NGKTLMFFEK LTNPRGYTCL LRGGSNAELT RVKRVASALL FARYNWRLEM SFLLNEFAQP 720
LSPKPSIFDS KETSPKTETE AELRSKRPII LERKSEDKIT TIVSENVSDF TDPLRASQAE 780
ALSTSPCAPP VVEALAVEPR YDNRFRTALS STLLSVSPFL TFPLPYLETE QGRKCKLRKL 840
FPAELYFSKQ WSRTGLERPD SMGDGEAGKS EPGNKENQMQ LLPAHDFVLM KITAPASSRD 900
IQSKLAEFRS FGGRLPKGKA PMLRPKKKNA EVIQRPQKVS EEQLYKDALD PQNHQRLPVL 960
FCSFHYNPKG VSSFCKLPML LDMKFYGQYD IMLEQFLQRY CCLFNSMCPS CNLPMLGHVR 1020
RYVHSLGCVH VYLTEDLTRS DPTRIYFTSW CSICNATTPT IPLSDAAKCL SLAKYLEMRF 1080
HGHAYKRRPP STDAEQGGTV CEHSLHRDYV HHFSFRGVGA KFQYTPVEVW ETDLPSLTVQ 1140
LDLPQPFQSA QVQEEIKNFS IKGHEVYNRI HERIADLATE EENSPLVQHL KTMLTHDQFI 1200
FKQKIEIVHT LLTDNRATAY DTSDALAMAR RALAESIELW GPRLQEIEKL TAKQAHHIDS 1260
GTICTEELRP EQVQTADSSK VTTSSLPKEN DPLECPSEDT ETGASNSQTV LDKNFSIDQM 1320
LASTVNVYSD KKSIRKILTQ LLPSGNQVNP LQSPFPAQDH LTLPLGSIPI HVRETDLSSV 1380
IAYSLTSMDY QKAIDEAEAN SNAAHSSPQL KRKIPLAESV SDAEDSPSLS RTSSNTSAAP 1440
NASVPSPATA ASESEEKSKE RIKQPPSPHI TLAFQDHSCQ FQCKIYFARE FDAMRSKSLK 1500
PPKLDKSLYR RLEKSKMREE LRISQSRTGS EMELVRKPSD VGAPRTTEDD SNQEEDARIA 1560
LARSLCKSVQ WEARGGKSGS RFCKTLDDRF VLKEMNSRDM TIFEPFAPKY FEYIDRCQQQ 1620
QQPTLLAKIF GVFRVSVKKK DSFVERSVMV MENLFYGCNI ENKFDLKGSE RNRLVDPSNQ 1680
QGEIVLLDEN LVQMSWSKPL YVLSHSKTVL RDAIQRDSSF LEKNLVMDYS LLVGLDKKNG 1740
VLVLGIIDYI RTFTLDKRVE SIIKGSGILG GKGKDPTVVN PERYKQRFID AMDRYFLTVP 1800
DRWEGLSKV
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0967--Endosome
KW-0418--Kinase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002423--Cpn60/TCP-1
IPR000591--DEP_dom
IPR027409--GroEL-like_apical_dom
IPR027483--PInositol-4-P-5-kinase_C
IPR002498--PInositol-4-P-5-kinase_core
IPR027484--PInositol-4-P-5-kinase_N
IPR016034--PInositol-4P-5-kinase_core_sub
IPR011991--WHTH_DNA-bd_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50186--DEP
PS51455--PIPK
PS50178--ZF_FYVE

Pfam

PF00118--Cpn60_TCP1
PF01363--FYVE
PF01504--PIP5K

Gene Ontology

GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0012506--C:vesicle membrane
GO:0000285--F:1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0016308--F:1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524--F:ATP binding
GO:0008270--F:zinc ion binding
GO:0097352--P:autophagosome maturation
GO:0008333--P:endosome to lysosome transport
GO:0035556--P:intracellular signal transduction
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0016310--P:phosphorylation