dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0003722
Uniprot Accession O96433; CCNT_DROME; Q9VVI6;
Genbank Protein ID NP_001261992.1; NP_001261993.1; NP_524127.2; NP_996117.1;
Genbank Nucleotide ID NM_001275063.2; NM_001275064.2; NM_079403.4; NM_206395.3;
Protein Name Cyclin-T
Protein Synonyms/Alias
Gene Name CycT
Gene Synonyms/Alias CG6292;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
285RLKSKLNSIKAIAQGcurated22817900
297AQGASNRTANSKDKPcurated22817900
421GYNNRMPSSHQRSSScurated22817900
438LGSSGSGSQRSSSSSPhosphoPep 2.0;curated19060867; 22817900
621QSKNSLFSPEWPDIKPHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated21081558; 19060867; 18327897; 19366988; 22817900
665SHPRDKESPKKERLTPHOSIDA;curated21081558; 22817900
732LKRPNEISGSQYGLNPhosphoPep 2.019060867
734RPNEISGSQYGLNKLPhosphoPep 2.0;curated19060867; 22817900
916GSGGSKDSSLPNEPLdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
Sequence
(Fasta)		MSLLATPMPQ AATASSSSSA SAAASASGIP ITANNNLPFE KDKIWYFSND QLANSPSRRC 60
GIKGDDELQY RQMTAYLIQE MGQRLQVSQL CINTAIVYMH RFYAFHSFTH FHRNSMASAS 120
LFLAAKVEEQ PRKLEHVIRA ANKCLPPTTE QNYAELAQEL VFNENVLLQT LGFDVAIDHP 180
HTHVVRTCQL VKACKDLAQT SYFLASNSLH LTSMCLQYRP TVVACFCIYL ACKWSRWEIP 240
QSTEGKHWFY YVDKTVSLDL LKQLTDEFIA IYEKSPARLK SKLNSIKAIA QGASNRTANS 300
KDKPKEDWKI TEMMKGYHSN ITTPPELLNG NDSRDRDRDR ERERERERDP SSLLPPPAMV 360
PQQRRQDGGH QRSSSVSGVP GSSSSSSSSS HKMPNYPGGM PPDAHTDHKS KQPGYNNRMP 420
SSHQRSSSSG LGSSGSGSQR SSSSSSSSSQ QPGRPSMPVD YHKSSRGMPP VGVGMPPHGS 480
HKMTSGSKPQ QPQQQPVPHP SASNSSASGM SSKDKSQSNK MYPNAPPPYS NSAPQNPLMS 540
RGGYPGASNG SQPPPPAGYG GHRSKSGSTV HGMPPFEQQL PYSQSQSYGH MQQQPVPQSQ 600
QQQMPPEASQ HSLQSKNSLF SPEWPDIKKE PMSQSQPQPF NGLLPPPAPP GHDYKLNSHP 660
RDKESPKKER LTPTKKDKHR PVMPPVGSGN SSSGSGSSKP MLPPHKKQIP HGGDLLTNPG 720
ESGSLKRPNE ISGSQYGLNK LDEIDNSNMP REKLRKLDTT TGLPTYPNYE EKHTPLNMSN 780
GIETTPDLVR SLLKESLCPS NASLLKPDAL TMPGLKPPAE LLEPMPAPAT IKKEQGITPM 840
TSLASGPAPM DLEVPTKQAG EIKEESSSKS EKKKKKDKHK HKEKDKSKDK TEKEERKKHK 900
KDKQKDRSGS GGSKDSSLPN EPLKMVIKNP NGSLQAGASA PIKLKISKNK VEPNNYSAAA 960
GLPGAIGYGL PPTTATTTSA SIGAAAPVLP PYGAGGGGYS SSGGSSSGGS SKKKHSDRDR 1020
DKESKKNKSQ DYAKYNGAGG GIFNPLGGAG AAPNMSGGMG APMSTAVPPS MLLAPTGAVP 1080
PSAAGLAPPP MPVYNKK 1098
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR013763--Cyclin-like
IPR006671--Cyclin_N
IPR015430--Cyclin_T
PROSITE
Pfam

PF00134--Cyclin_N
Gene Ontology

GO:0000307--C:cyclin-dependent protein kinase holoenzyme complex
GO:0032783--C:ELL-EAF complex
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0005703--C:polytene chromosome puff
GO:0008024--C:positive transcription elongation factor complex b
GO:0008023--C:transcription elongation factor complex
GO:0016538--F:cyclin-dependent protein serine/threonine kinase regulator activity
GO:0008353--F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007015--P:actin filament organization
GO:0000278--P:mitotic cell cycle
GO:0045737--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1901409--P:positive regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006468--P:protein phosphorylation
GO:0008360--P:regulation of cell shape
GO:0009408--P:response to heat
GO:0006351--P:transcription, DNA-templated